본문 바로가기
KERD
논문KCI 등재

제2형 당뇨병 환자들의 최대운동이 적혈구생성호르몬과 지방세포분비 단백질에 미치는 영향

The Effects of Maximal Exercise on EPO(Erythropoietin) and Adipokine in Type 2 Diabetes Patient

김현정|김영준|이재규|강성훈|이윤서|여남회
국민체육진흥공단 한국스포츠과학원 (Korea Institute of Sport Science)|2007.03|체육과학연구 (Korean Journal of Sport Science)|제18권 제1호|pp. 49-58|DOI 10.24985/kjss.2007.18.1.49

0

조회

0

다운로드

0

인용

0

참고문헌

키워드

AdiponectinType 2 Diabetes제2형 당뇨병EPOAdipokine적혈구생성호르몬지방세포분비 단백질RBP4
주제분류체육

초록

본 연구는 제2형 당뇨병 환자들의 최대운동이 적혈구생성호르몬과 지방세포분비 단백질에 미치는 영향을 알아보고자 실시하였다. 연구대상자들은 인슐린저항성을 보이는 제2형 당뇨병 환자들로서 스스로 연구에 참어를 동의한 사람들로서 무작위추출에 의해 실험A군(정상체중그룹, n=7), 실험B군(과체중그룹, n=8)으로 나누어 실시하였다. 측정내용은 체성분 분석기(Venus 5.5)를 통한 신체조성검사를 실시하였으며, 최대운동부하 검사는 Quark b2를 통해서 실시하였으며, 혈장과 혈청을 통해 HbA1c, EPO, IL-6, RBP4, Adiponectin을 검사하여 다음과 같은 결과를 얻었다. HbA1c는 유의한 감소가 나타났으며, EPO는 감소하였지만 통계적으로 유의성은 나타나지 않았다. 또한 RBP4는 최대운동전보다 운동후에 두그룹 모두 유의한 감소가 나타났으며, Adiponectin은 유의한 증가가 나타났다. 하지만 IL-6는 통계적으로 유의성이 나타나지 않았다. 따라서 인슐린저항성을 나타내는 제2형 당뇨병 환자들 중 특히 과체중환자들은 최대운동과 같은 탈진적 운동이 당수송을 촉진하여 지방세포에서 분비되는 단백질에 영향을 주는 것으로 사료된다.

Abstract

The purpose of this study was to investigate the effects of maximal exercise on EPO and adipokine in type 2 diabetes patient. Subjects were recruited and divided into 2 groups. One group of subjects was experiment A(n=7, normal weight group) and other group was experiment B(n=8, over weight group). Maximal exercise test used to Quark b2 that HbA1c, EPO, RBP4, IL-6, Adiponectin was measured from blood plasma and serum. The results showed that HbA1c was decreased significant and EPO was not significant. Serum RBP4 was decreased and adiponectin was increased significant after maximal exercise. But IL-6 was not changed. Therefore, in subjects type 2 diabetes insulin sensitivity in overweight group maximal exercise was positive on adipokine through glucose transport palpation.

참고문헌 (67)

  1. "당뇨병학 3판" (2005), 대한당뇨병학회
  2. "Retinol, alpha-tocopherol and carotenoids in diabetes", 53(8), pp.630~635 (1999)
  3. "Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver", 409(6821), pp.729~733 (2001)
  4. "Guidelines for exercise testing and prescription" (2005), Baltimore, Williams & Wilkins
  5. "Adipose tissue as an endocrine organ", 11(8), pp.327~332 (2000)
  6. "Effects of erythropoietin admini- stration in training athletes and possible indirect detection in doping control", 5, pp.639~645 (1999)
  7. "Vitamin A(retinol) status of first nation adults with non-insulin- dependent diabetes mellitus", 16(1), pp.39~45 (1997)
  8. "in vitro interaction with retinol-binding protein and influence on plasma retinol. FASEB. J. 7", . reti(ids), pp.1179~1184 (1993)
  9. "Issues related to blood sampling in athletes for doping control", 28, pp.25~30 (1999)
  10. "Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury", 99(4), pp.2258~2263 (2002)
  11. "Adiponectin: more than just another fat cell hormone?", 26, pp.2442~2450 (2003)
  12. "Evidence for an essential role of megalin in transepithelial transport of retinol", 10(4), pp.685~695 (1999)
  13. "A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivity", 145, pp.367~383 (2004)
  14. "Faster oxygen uptake kinetics at the onset of submaximal cycling exercise following 4 weeks recombinant human erythropoietin(r-HuEPO) treatment", 447, pp.231~238 (2003)
  15. "The role of the novel adipocyte-derived hormone adiponectin in human disease", 148, pp.293~300 (2003)
  16. ". Rate of erythropoietin formation in response to acute hypobaric hypoxia. J. Appl. Physiol. 66", pp.1785~1788 (1989)
  17. ". Effect of erythropoietin administration on maximal aerobic power. Scand. J. Med. Sci. Sports. 1", pp.88~93 (1991)
  18. "Clinical practice guidelines: final guideline summaries from the work groups of the national kidney foundation-dialysis outcomes quality initiative" (1997), New York : National Kidney Foundation
  19. ". In vitro production of erythropoietin by kidneys perfused with a serum free solution. Blood. 44", pp.77~85 (1974)
  20. "Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans", 145, pp.2273~2282 (2004)
  21. "Muscle-derived interleukin-6: mechanisms for activation and possible biological roles", 16, pp.1335~1347 (2002)
  22. "Health Fitness Instructor's Handbook" (1998), Human Kinetics
  23. "Haemoglobin, blood volume, cardiac function, and aerobic power", 24, pp.54~65 (1999)
  24. "Exercising skeletal muscle blood flow in humans responds to reduction in arterial oxyhaemoglobin, but not to altered free oxygen", 530, pp.331~341 (2001)
  25. "Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects", 354(24), pp.1 2552~2563 (2006)
  26. "Plasma leptin concentrations in obese children: changes during 4-mo periods with and without physical training", 69, pp.388~394 (1999)
  27. "Body composition is related to increase in plasma adiponectin levels rather than trining in young obese men", 94, pp.520~526 (2005)
  28. "Circulation concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys", 50, pp.1126~1133 (2001)
  29. "AdipoQ is novel adipose-specific gene dysregulated in obesity", 271, pp.10697~10703 (1996)
  30. "Adiponectin is not altered with exercise training despite enhanced insulin action", 283, pp.E861~E865 (2002)
  31. "the enigma of the metabolic fate of circulation erythropoietin(EPO) in view of the pharmacokinetics of the recombinant drugs r-hEPO and NESP", 69, pp.265~274 (2002)
  32. "Adipose tissue as an endocrine organ", 89, pp.2548~2556 (2004)
  33. "Adiponectin and HIV- lipodystrophy: taking HAART", 145, pp.484~486 (2004)
  34. ". Erythropoietin response to acute normobaric hypoxia in humans. J. Appl. Physiol.", pp.837~840 (1992)
  35. "EPO, red cells, and serum transferrin receptor in continuous and intermittent hypoxia", 32(4), pp.800~804 (2000)
  36. ". Erythropoietin retards DNA breakdown and prevents programmed death in erythroid progenitor cells. Science. 248", pp.378~381 (1990)
  37. "Exercise increases adiponectin levels and insulin sensitivity in humans", 27, pp.629~630 (2004)
  38. "Disruption of adiponectin cause insulin resistance and neointimal formation", 277, pp.25863~25866 (2002)
  39. "cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1(Adipose most abundant gene transcript 1)", 221, pp.286~289 (1996)
  40. "Effect of erythropoietin on exercise capacity in patients with moderate to severe chronic heart failure", 107(2), pp.294~299 (2003)
  41. "Effect of erythropoietin on muscle O2 transport during exercise in patients with chronic renal failure", 97, pp.2092~2100 (1996)
  42. ". Specific uptake of retinol-binding protein by variant F9 cell lines. J. Biol. Chem. 268", pp.18859~18865 (1993)
  43. "Physical performance and associated electrolyte changes after hemoglobin normalization: a comparative study in haemodialysis patients", 14, pp.1182~1187 (1999)
  44. "The transthyretin-retinol-binding protein complex", 1482(1-2), pp.65~72 (2000)
  45. "Increasing the hematocrit has a beneficial effect on quality of life and is safe in selected hemodialysis patients", 11, pp.335~342 (2000)
  46. ". Apoptosis of human erythroid colony-forming cells is decreased by stem cell factor and insulin-like growth factor I as well as erythropoietin. J. Cell Physiol.", pp.264~271 (1993)
  47. "Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma", 120, pp.803~812 (1996)
  48. "A novel protective effect of erythropoietin in the infarcted heart", 112(7), pp.999~1007 (2003)
  49. "The effect of exercise training on leptin levels in obese males", 274, pp.280~286 (1998)
  50. "Exercise and the immune system: regulation, integration and adaptation", 80, pp.1055~1081 (2000)
  51. "Searching for the exercise factor: is IL6 a candidate", 24, pp.113~119 (2003)
  52. "Muscle-derived interleukin-6: possible biological effects", 536, pp.329~337 (2001)
  53. "Impaired retinal function and vitamin A availability in mice lacking retinol-binding protein", 18(17), pp.4633~4644 (1999)
  54. "The insulin resistance syndrome: definition and dietary approaches to treatment", 25, pp.391~406 (2005)
  55. "Effects of porlonged low doses of recombinant human erythropoietin during submaximal and maximal exercise", 86, pp.442~449 (2002)
  56. "Adiponectin levels do not change with moderate dietary induced weight loss and exercise in obese postmenopausal women", 279, pp.1066~1071 (2003)
  57. "What is a normal red blood cell mass for professional cyclists?", 352, pp.1758~ (1998)
  58. "A novel serum protein similar to C1q, produced exclusively in adipocytes", 270, pp.26746~26749 (1995)
  59. "Erythropoietin attenuated high glucose-induced apoptosis in cultured human aortic endothelial cells", 334(1), pp.218~222 (2005)
  60. "Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress", 98(7), pp.4044~4049 (2001)
  61. ". The interaction of retinol-binding protein with its plasma-membrane receptor. Biochem. J. 255", pp.561~569 (1988)
  62. "RBP4, an unexpected adipokine", 12(1), pp.30~31 (2006)
  63. "Moderate-intensity regular exercise decrease serum tumor necrosis factor-α and HbA1c levels in healthy women", 24, pp.1207~1211 (2000)
  64. "Cloning of adiponectin receptors that mediate antidiabetic metabolic effects", 423, pp.762~769 (2003)
  65. "Serum retionl binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes", 436(7049), pp.356~362 (2005)
  66. "Relationship between exercise training-induced increase in insulin sensitivity and adiponectinemia in healthy men", 50, pp.233~238 (2003)
  67. "Effect of aerobic exercise on plasma adiponectin levels and insulin resistance in type 2 diabetes", 27, pp.1756~1758 (2004)

관련 논문AI추천

운동형태가 제2형 당뇨병 여성 환자의 사이토카인에 미치는 영향강성훈, 김정규, 김철우, 박규민, 유현승대한운동학회 · 아시아 운동학 학술지2016 · 제18권 제4호12주간의 유산소운동과 저항성운동이 여성 노인 당뇨병환자의 복부지방, 체력, 아디포카인 및 염증지표에 미치는 영향임수, 김예영, 이만균, 최순미국민체육진흥공단 한국스포츠과학원 · 체육과학연구2012 · 제23권 제3호유산소 운동이 건강한 성인의 인슐린감수성과 말초혈액 단핵세포의아디포넥틴 수용체 mRNA 발현에 미치는 영향강현식, 박승우, 이신호, 조진경, 하창덕국민체육진흥공단 한국스포츠과학원 · 체육과학연구2013 · 제24권 제3호고강도 인터벌 운동이 제2형 당뇨병에 미치는 실험연구 문헌고찰장용철, 조준용, 최동훈대한체육학회 · 대한체육학회지2020 · 제18권 제2호일회성 유산소운동이 비만 중년여성의 염증반응인자와 혈중 아디포넥틴에 미치는 영향석민화, 신윤아, 임강일대한임상건강증진학회 · Korean Journal of Health Promotion2012 · 제12권 제4호걷기 운동이 성인 제 2형 당뇨병 환자들의 당뇨지표 및혈관탄성도에 미치는 영향곽이섭, 김경철, 김이순, 박성모대한한의진단학회 · 대한한의진단학회지2013 · 제17권 제3호

이 간행물의 다른 논문 (11건)

12주 Pilates 운동이 여대학생의 유연성, 근력 및 신체구성에 미치는 영향윤성원, 윤승호, 박경혜pp. 1-8다운증후군 아동의 보행 향상을 위한 근육활동 규명최범권, 최치선, 임비오pp. 9-18정상체중인과 비만체중인의 보행속도에 따른 하지근 파워 비교분석김태완, 김지태pp. 19-29승무 연풍대 동작의 운동학적 분석이지선pp. 30-38씨름선수의 윙게이트 검사 중 산소기여율 증가시점을 바탕으로 무산소성 운동능력 평가변인의 제안김원현, 이범기, 김도윤, 장지영pp. 39-48
원문 보기