정상안 및 황반 질환에서 스펙트럼 영역 빛간섭단층촬영(3D-OCT 1000)의 황반 두께 및 부피 반복성
Repeatability of Spectral Domain OCT (3D-OCT 1000) in Normal Subjects and Various Macular Diseases
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목적: 정상안 및 다양한 황반 질환에서 스펙트럼 영역 빛간섭단층촬영을 이용하여 황반 두께 및황반 부피를 측정하여 반복성을 알아보고, 각 질환 군별 반복성의 차이를 비교해 보고자 하였다. 대상과 방법: 대상안 총 108안 중 정상안이 50안, 당뇨 황반부종이 20안, 망막 정맥 폐쇄 10안, 연령 관련 황반 변성 15안, 기타 13안이었다. 스펙트럼 영역 빛간섭단층촬영으로 한명의 검사자가 2회 연속으로 황반 중심부 두께, 황반 주변부 두께 및 총 황반 부피를측정하였으며, 각 질환 군별로 급내 상관계수를 구하여 반복성의 정도를 비교하였다. 결과: 스펙트럼 영역 빛간섭단층촬영기는 정상안 및 여러 황반 질환군에서 황반 두께 및 황반 부피 측정에 반복성이 있었고, 반복성은정상안군에서 가장 높았으며, 기타군, 연령 관련 황반 변성군, 망막 정맥 폐쇄군, 당뇨 황반부종군의 순이었다. 결론: 스펙트럼 영역 빛간섭단층촬영기는 반복성이 있으나, 정상 및 각 질환 마다 반복성의 차이가 있었다. 이는 각 질환에서 나타나는병태해부학적인 원인 때문인 것으로 생각되며, 임상적으로 결과 해석 시 유의하여야 할 것으로 사료된다.
Abstract
Purpose: To evaluate the repeatability of macular thickness and total macular volume measurements made using spectral domain optical coherence tomography (OCT) in normal subjects and subjects with macular disease. Methods: Among a total of 108 subjects, there were 50 normal subjucts, 20 patients with diabetic macular edema, 10 patients with retinal vein occlusion, 15 patients with age-related macular degeneration, and 13 subjects with other conditions. Two serial macular measurements were obtained from each subject by a single experienced examiner using spectral domain OCT. The repeatability of the measurements was evaluated by comparing two consecutive foveal and perifoveal thickness measurements and total macular volume measurements. The intraclass correlation coefficient was also calculated to evaluate the repeatability of measurements made in normal and macular disease subjects. Result: Spectral domain OCT measurements of macular thickness and macular volume were found to be consistent. Measurements of normal subjects were the most consistent, followed by measurements of patients with age-related macular degeneration, retinal vein occlusion, and diabetic macular edema. Conclusions: Although measurements made using spectral domain OCT were repeatable across all subjects, they were more consistent in normal subjects than in patients with macular disease. The differences in repeatability should be considered in the context of diseased pathologic anatomy. Physicians should remain cautious when using these measurements for clinical evaluation.
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