스펙트럼 영역 빛간섭단층촬영 결과에 영향을 주는 다양한 인자 분석
Analysis of Factors Associated with Variability in Measures Obtained by Spectral Domain Optical Coherence Tomography
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목적: 스펙트럼 영역 빛간섭단층촬영의 결과에 영향을 주는 인자들에 대해 알아보고자 하였다. 대상과 방법: 최대 교정시력 0.6 이상으로 세극등과 안저 검사상 이상이 없는 196명 370안을 대상으로 하였다. 모든 환자에서 Cirrus HD-OCT의 Macular cube 512×128 combination scan mode와 Optic disc cube 200×200 scan mode로 촬영한 자료를 분석하였다. 황반과 시신경유두 주위 망막신경섬유층의 빛간섭단층촬영 결과와 환자의 연령, 성별, 좌우안, 굴절 대응치, 그리고 측정 신호강도(signal strength)가 결과값에 주는 영향을 알아보았다. 결과: 여성에서 남성에 비해 유의하게 얇은 중심황반두께를 보였다(r=-0.260, p=0.000). 연령이 증가함에 따라 평균 내측황반두께와평균 외측황반두께가 증가하였다(r=0.153, p=0.010; r=0.193, p=0.001). 굴절 대응치는 중심황반두께와 음의 상관관계를 보였으나(r=-0.352, p=0.000), 평균 내측황반두께, 평균 외측황반두께, 전체 황반부 평균 두께 및 부피, 평균 망막신경섬유층 두께와 양의 상관관계를 보였다(r=0.181, p=0.002; r=0.287, p=0.000; r=0.346, p=0.000; r=0.341, p=0.000; and r=0.261, p=0.000). 측정 신호강도는 평균 내측황반두께와 음의 상관관계를 보였다(r=-0.136, p=0.023). 결론: 스펙트럼 영역 빛간섭단층촬영을 이용한 망막의 두께를 측정한 결과는 성별, 연령, 굴절 대응치, 측정 신호 강도에 영향을 받기때문에 빛간섭단층촬영의 결과를 해석할 때에는 이러한 인자들의 영향을 고려하여 해석하여야 하겠다.
Abstract
Purpose: To identify factors associated with variability in measures obtained by spectral domain optical coherence tomography (SD-OCT). Methods: One hundred ninety-six subjects (370 eyes) with no ophthalmic evidence of retinopathy and with corrected visual acuities better than 0.6 were included. Macular thickness and retinal nerve fiber layer (RNFL) thickness were measured using SD-OCT and were analyzed according to sex, laterality, age, spherical equivalent and signal strength. Results: The central subfield thickness was significantly lower in the female subjects (r = -0.260, p = 0.000). As age increased,average inner and outer macular thickness increased significantly (r = 0.153, p = 0.010; r = 0.193, p = 0.001). Spherical equivalent correlated negatively with central subfield thickness (r = -0.352, p = 0.000) but correlated positively with average inner macular thickness, average outer macular thickness, overall average thickness, overall macular volume,and average RNFL thickness (r = 0.181, p = 0.002; r = 0.287, p = 0.000; r = 0.346, p = 0.000; r = 0.341, p = 0.000; and r = 0.261, p = 0.000, respectively). Signal strength correlated negatively with average inner macular thickness (r = -0.136,p = 0.023). Conclusions: SD-OCT shows that retinal thickness is related to age, sex, spherical equivalent and signal strength. Analysis of retinal thickness by SD-OCT should be interpreted in the context of these findings.
참고문헌 (29)
- Nussenblatt RB, "Macular thickening and visual acuity. Measurement in patients with cystoid macular edema", Ophthalmology, 94, pp.1134~1139 (1987)
- Lee SC, "Macular Thickness Variations with Sex, Age, and Axial Length in Healthy Subjects: A Spectral Domain-Optical Coherence Tomography Study", INVESTIGATIVE OPHTHALMOLOGY VISUAL SCIENCE, 51(8), pp.3913~3918 (2010), ASSOC RESEARCH VISION OPHTHALMOLOGY INC
- 문성운, "시간영역과 스펙트럼영역 빛간섭단층촬영기의 황반두께 측정치 및 반복성의 비교", 대한안과학회지, 50(7), pp.1050~1059 (2009), 대한안과학회
- 강명수, "스펙트럼영역 빛간섭단층촬영기로 측정한한국인 정상안의 황반부 용적", 대한안과학회지, 51(8), pp.1077~1083 (2010), 대한안과학회
- 김승훈, "정시안에서 스펙트럼영역 빛간섭단층촬영기를 이용한 연령과 성별에 따른 황반 두께의 변화", 대한안과학회지, 52(3), pp.299~307 (2011), 대한안과학회
- Lim MC, "Use of optical coherence tomography to assess variations in macular retinal thickness in myopia", Invest Ophthalmol Vis Sci, 46, pp.974~978 (2005)
- Asrani S, "Noninvasive mapping of the normal retinal thickness at the posterior pole", Ophthalmology, 106, pp.269~273 (1999)
- 김부기, "시간영역 빛간섭단층촬영기와 스펙트럼영역 빛간섭단층촬영기로 측정한 망막신경섬유층 두께 비교", 대한안과학회지, 50(10), pp.1539~1547 (2009), 대한안과학회
- 이영록, "녹내장 진단에서 스펙트럼 영역 빛간섭단층촬영기로 측정한 황반과 망막신경섬유층 두께의 유용성", 대한안과학회지, 51(9), pp.1250~1257 (2010), 대한안과학회
- Wong AC, "Relationship of gender, body mass index, and axial length with central retinal thickness using optical coherence tomography", Eye (Lond), 19, pp.292~297 (2005)
- Duan XR, "Normal macular thickness measurements using optical coherence tomography in healthy eyes of adult Chinese persons: the Handan Eye Study", Ophthalmology, 117, pp.1585~1594 (2010)
- Massin P, "Retinal thickness in healthy and diabetic subjects measured using optical coherence tomography mapping software", Eur J Ophthalmol, 12, pp.102~108 (2002)
- Evans JR, "Systemic risk factors for idiopathic macular holes: a case-control study", Eye (Lond), 12(Pt 2), pp.256~259 (1998)
- "Risk factors for idiopathic macular holes. The Eye Disease Case-Control Study Group", Am J Ophthalmol, 118, pp.754~761 (1994)
- Panda-Jonas S, "Retinal photoreceptor density decreases with age", Ophthalmology, 102, pp.1853~1859 (1995)
- Landau D, "Quantitative in vivo retinal thickness measurements in healthy subjects", Ophthalmology, 104, pp.639~642 (1997)
- Zou H, "Quantitative in vivo retinal thickness measurement in Chinese healthy subjects with retinal thickness analyzer", Invest Ophthalmol Vis Sci, 47, pp.341~347 (2006)
- Chan CM, "Posterior pole retinal thickness measurements by the retinal thickness analyzer in healthy Chinese subjects", Retina, 26, pp.176~181 (2006)
- Chan A, "Normal macular thickness measurements in healthy eyes using Stratus optical coherence tomography", Arch Ophthalmol, 124, pp.193~198 (2006)
- Wakitani Y, "Macular thickness measurements in healthy subjects with different axial lengths using optical coherence tomography", Retina, 23, pp.177~182 (2003)
- Lam DS, "Regional variations in the relationship between macular thickness measurements and myopia", Invest Ophthalmol Vis Sci, 48, pp.376~382 (2007)
- Eriksson U, "Macular thickness decreases with age in normal eyes: a study on the macular thickness map protocol in the Stratus OCT", Br J Ophthalmol, 93, pp.1448~1452 (2009)
- Varma R, "Optical tomography-measured retinal nerve fiber layer thickness in normal latinos", Invest Ophthalmol Vis Sci, 44, pp.3369~3373 (2003)
- Budenz DL, "Determinants of normal retinal nerve fiber layer thickness measured by Stratus OCT", Ophthalmology, 114, pp.1046~1052 (2007)
- Schuman JS, "Quantification of nerve fiber layer thickness in normal and glaucomatous eyes using optical coherence tomography", Arch Ophthalmol, 113, pp.586~596 (1995)
- Apple DJ, "Clinicopathologic Correlation of Ocular Disease : A Text and Stereoscopic Atlas", pp.39~44 (1978), Mosby
- Yanoff M, "Ocular Pathology, A Text and Atlas", pp.513~514 (1982), Haper & Row
- Wu Z, "Factors associated with variability in retinal nerve fiber layer thickness measurements obtained by optical coherence tomography", Ophthalmology, 114, pp.1505~1512 (2007)
- Samarawickrama C, "Influence of OCT signal strength on macular, optic nerve head, and retinal nerve fiber layer parameters", Invest Ophthalmol Vis Sci, 51, pp.4471~4475 (2010)