스펙트럼영역 빛간섭단층촬영기를 이용한 정상인의 망막층별 두께 측정치의 반복성
The Repeatability of Retinal Layer Thickness Measurements with Spectral-Domain Optical Coherence Tomography in Normal Eyes
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초록
목적: 정상인에서 스펙트럼영역 빛간섭단층촬영기(Spectral-domain optical coherence tomography, SD-OCT)를 이용하여 황반부를 구역별로 나누어 망막층별 두께를 측정하고 그 반복성을 알아보고자 하였다. 대상과 방법: 정상인 34명의 총 68안을 대상으로 스펙트럼영역 빛간섭단층촬영기를 이용하여 한 명의 검사자가 2회 측정한 후, 1시간 간격을 두고 2회 추가 시행하여 각각의 측정치를 비교 분석하였다. 황반부를 9개의 Early Treatment Diabetic Retinopathy Study (ETDRS) 구획(subfield)으로 나누어 구역별 평균 망막 두께와 층별 두께를 측정하여 측정치 간의 급내상관계수(intraclass correlation coefficients, ICCs)를 분석하여 반복성을 평가하였다. 결과: 단일 검사자에 의한 평균 망막 두께는 측정치 간 유의한 차이를 보이지 않았고(p＞0.05), 급내상관계수는 모든 구획에서 0.918 이상의 높은 반복성을 보였다. 또한 층별 두께 역시 측정치 간 유의한 차이를 보이지 않았으며, 중심와의 내경계막과 신경섬유층, 신경절세포층과 내망상층, 내핵층과 외망상층에서 급내상관계수 0.826-0.847의 비교적 높은 반복성을 보였고, 이 중심와 3개층을 제외한 모든 구획의 나머지 전 층(all layer)에서 급내상관계수 0.909 이상의 매우 높은 반복성을 보였다. 결론: 스펙트럼영역 빛간섭단층촬영기는 황반부 구역별 평균 망막 두께와 층별 두께 측정에서 반복성이 뛰어난 결과를 나타내어 높은신뢰성을 보였다.
Abstract
Purpose: To evaluate the repeatability of retinal layer thickness measurements in normal eyes imaged using spectral domain optical coherence tomography (SD-OCT). Methods: Sixty-eight eyes of 34 healthy subjects were enrolled in this study. Imaging was performed 4 times using 9 × 9 mm macular scans with SD-OCT (RS 3000 Advance HD OCT, NIDEK, Gamagori, Japan) at the same visit by an experienced examiner. After automatic retinal segmentation (layering) in 5 layers, the thickness of each layer was calculated. Macular thickness of 9 Early Treatment of Diabetic Retinopathy Study (ETDRS)–like regions was obtained. Repeatability for each of the 9 subfield areas was calculated by their repeatability coefficients and intraclass correlation coefficients (ICCs). Results: There was no significant difference in average retinal thickness and each retinal layer thickness between all measurements acquired by the experienced examiner. The ICCs of retinal layer thickness ranged from 0.826 to 0.847 for the ganglion cell layer + inner plexiform layer, inner nuclear layer + outer plexiform layer and outer nuclear layer + external limiting membrane in the fovea. The ICCs were greater than 0.909 for the other intra-retinal layers in all 9 ETDRS subfield thickness between all measurement pairs. Conclusions: Excellent repeatability was observed for SD-OCT retinal segmented layer thickness measurements in healthy subjects.
참고문헌 (26)
- Leung CK., "Comparison of macular thickness measurements between time domain and spectral domain optical coherence tomography", Invest Ophthalmol Vis Sci, 49, pp.4893~4897 (2008)
- Menke MN., "Reproducibility of retinal thickness measurements in healthy subjects using spectralis optical coherence tomography", Am J Ophthalmol, 147, pp.467~472 (2009)
- Han IC., "Comparison of spectral- and time-domain optical coherence tomography for retinal thickness measurements in healthy and diseased eyes", Am J Ophthalmol, 147, pp.847, 858.e~858, 858.e (2009)
- Vizzeri G., "Agreement between spectral-domain and time-domain OCT for measuring RNFL thickness", Br J Ophthalmol, 93, pp.775~781 (2009)
- Hess DB., "Macular and retinal nerve fiber layer analysis of normal and glaucomatous eyes in children using optical coherence tomography", Am J Ophthalmol, 139, pp.509~517 (2005)
- Leung CK., "Retinal nerve fiber layer measurements in myopia : an optical coherence tomography study", Invest Ophthalmol Vis Sci, 47, pp.5171~5176 (2006)
- Kotowski J., "Glaucoma discrimination of segmented cirrus spectral domain optical coherence tomography(SD-OCT)macular scans", Br J Ophthalmol, 96, pp.1420~1425 (2012)
- Matsumoto H., "Outer nuclear layer thickness at the fovea determines visual outcomes in resolved central serous chorioretinopathy", Am J Ophthalmol, 148, pp.105.e1~110.e1 (2009)
- Acton JH., "Relationship between retinal layer thickness and the visual field in early age-related macular degeneration", Invest Ophthalmol Vis Sci, 53, pp.7618~7624 (2012)
- Huang J., "Macular thickness measurements in normal eyes with time-domain and Fourier-domain optical coherence tomography", Retina, 29, pp.980~987 (2009)
- Mansouri K., "Evaluation of retinal and choroidal thickness by swept-source optical coherence tomography : repeatability and assessment of artifacts", Am J Ophthalmol, 157, pp.1022~1032 (2014)
- Muscat S., "Repeatability and reproducibility of macular thickness measurements with the Humphrey OCT system", Invest Ophthalmol Vis Sci, 43, pp.490~495 (2002)
- 오세범, "정상인에서 시간 도메인과 스펙트럼 도메인 빛간섭단층촬영으로 측정한 황반두께 측정의 반복성 및 일치도", 대한안과학회지, 50(5), pp.710~716 (2009), 대한안과학회
- "Photocoagulation for diabetic macular edema. Early Treatment Diabetic Retinopathy Study report number 1. Early Treatment Diabetic Retinopathy Study research group", Arch Ophthalmol, 103, pp.1796~1806 (1985)
- Pierro L., "Retinal nerve fiber layer thickness reproducibility using seven different OCT instruments", Invest Ophthalmol Vis Sci, 53, pp.5912~5920 (2012)
- Kiernan DF., "En face spectral-domain optical coherence tomography outer retinal analysis and relation to visual acuity", Retina, 32, pp.1077~1086 (2012)
- Mohammad F., "A method for En Face OCT Imaging of subretinal fluid in age-related macular degeneration", J Ophthalmol, 2014, pp.720243~ (2014)
- Geitzenauer W., "Retinal optical coherence tomography : past, present and future perspectives", Br J Ophthalmol, 95, pp.171~177 (2011)
- Watanabe A., "Correlation between metamorphopsia and epiretinal membrane optical coherence tomography findings", Ophthalmology, 116, pp.1788~1793 (2009)
- Koo HC., "Morphologic and functional association of retinal layers beneath the epiretinal membrane with spectral-domain optical coherence tomography in eyes without photoreceptor abnormality", Graefes Arch Clin Exp Ophthalmol, 250, pp.491~498 (2012)
- 문성운, "시간영역과 스펙트럼영역 빛간섭단층촬영기의 황반두께 측정치 및 반복성의 비교", 대한안과학회지, 50(7), pp.1050~1059 (2009), 대한안과학회
- Carpineto P., "Reproducibility and repeatability of ganglion cell-inner plexiform layer thickness measurements in healthy subjects", Ophthalmologica, 232, pp.163~169 (2014)
- Ng DS., "Repeatability of perimacular ganglion cell complex analysis with spectral-domain optical coherence tomography", J Ophthalmol, 2015, pp.605940~ (2015)
- Müller R., "A critical discussion of intraclass correlation coefficients", Stat Med, 13, pp.2465~2476 (1994)
- 강나희, "스펙트럼영역 빛간섭단층촬영기를 이용한 정상인의 황반부 측정치와 측정의 반복성 및 재현성", 대한안과학회지, 52(10), pp.1182~1188 (2011), 대한안과학회
- Polito A., "Comparison between retinal thickness analyzer and optical coherence tomography for assessment of foveal thickness in eyes with macular disease", Am J Ophthalmol, 134, pp.240~251 (2002)