상안검에 국한되어 발생한 Merkel 세포 종양 1예
A Case of Localized Merkel Cell Carcinoma on the Upper Eyelid
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목적: 전이 소견 없이 상안검에만 국한된 Merkel 세포 종양을 수술적 절제술과 예방적 방사선 요법만으로 좋은 치료 결과를 보인 1예를면역조직화학적 염색 소견과 함께 보고하고자 한다. 증례요약: 76세 여자환자가 2개월 전부터 발생한 좌측 상안검의 0.6×0.9 cm 크기의 급속히 커지는 자홍색의 무통성 종괴를 주소로내원하였다. 수술적 절제를 시행하였으며 면역조직화학적 검사에서 synaptophysin에 양성 소견을 보였고 LAC (leukocyte common antigen), cytokeratin에는 음성 소견을 보여 Merkel 세포 종양으로 진단되었다. 절제 경계면이 침범되어 추가적인 절제 수술을 시행하였으며 국소적 재발 및 전이 소견은 관찰되지 않았다. 국소적 방사선 요법이 시행되었고 수술 후 10개월 경과관찰 동안 재발 소견이관찰되지 않았다.
Abstract
Purpose: To report a case of Merkel cell carcinoma on the left upper eyelid without metastasis and its immunohistochemical features. The carcinoma was successfully treated with excisional surgery and prophylactic radiation therapy. Case summary: A 76-year-old woman presented to the hospital complaining of a 0.6 × 0.9-cm-sized painless and purplish-red colored mass that had grown rapidly on her left upper eyelid margin over the previous two months. An excisional biopsy was performed. On immunohistochemical examination of the lesion, the tumor cells expressed immunoreactivity for synaptophysin and were negative for LAC and cytokeratin, confirming the diagnosis of Merkel cell carcinoma. Additional surgery was performed because the surgical margins were positive. No other primary or metastatic lesions were found. The patient was treated with local prophylactic irradiation and remained disease-free at her 10-month follow-up visit.
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