결막에 발생한 CK20 음성, CK7 양성 Merkel세포암종 - 짧은 증례 보고 -
CK20 Negative and CK7 Positive Merkel Cell Carcinoma of the Conjunctiva - Brief Case Report -
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Merkel cell carcinoma (MCC) is an uncommon but potentially aggressive neuroendocrine carcinoma of the skin. It typically develops on sun-exposed areas of the head and neck, particularly the eyelid, periorbital region, and extremities. We report a case of unusually located MCC, presenting as a conjunctival mass, which has only been reported once in the English literature. An 83-year-old male presented with a 0.8 × 0.7 cm sized mass protruding from the lower fornix of the right conjunctiva. The mass was excised. The tumor was located in the submucosa without connection to the overlying mucosa. Light microscopic findings showed a carcinoma with undifferentiated small round cells and the presence of cytokeratin (CK AE1/3, CK7) and neuroendocrine markers. We established a diagnosis of MCC. As reported in the literature, the majority of MCCs are positive for CK20 but negative for CK7. But, this case showed an uncommon cytokeratin immunohistochemical profile of positive for CK7 and negative for CK20, suggesting a new immunophenotypic MCC variant.
Abstract
Merkel cell carcinoma (MCC) is an uncommon but potentially aggressive neuroendocrine carcinoma of the skin. It typically develops on sun-exposed areas of the head and neck, particularly the eyelid, periorbital region, and extremities. We report a case of unusually located MCC, presenting as a conjunctival mass, which has only been reported once in the English literature. An 83-year-old male presented with a 0.8 × 0.7 cm sized mass protruding from the lower fornix of the right conjunctiva. The mass was excised. The tumor was located in the submucosa without connection to the overlying mucosa. Light microscopic findings showed a carcinoma with undifferentiated small round cells and the presence of cytokeratin (CK AE1/3, CK7) and neuroendocrine markers. We established a diagnosis of MCC. As reported in the literature, the majority of MCCs are positive for CK20 but negative for CK7. But, this case showed an uncommon cytokeratin immunohistochemical profile of positive for CK7 and negative for CK20, suggesting a new immunophenotypic MCC variant.
참고문헌 (7)
- Brenn T, "Tumors of the surface epithelium. In: Pathology of the skin with clinical correlations. 3rd ed", pp.1153~1240 (2005), Mosby-Elsevier
- Di Maria A, "Primary neuroendocrine carcinoma("Merkel cell tumor")of the eyelid:a report of two cases", Orbit, 19, pp.171~177 (2000)
- Toker C, "Trabecular carcinoma of the skin", Arch Dermatol, 105, pp.107~110 (1972)
- Llombart B, "Clinicopathological and immunohistochemical analysis of 20 cases of Merkel cell carcinoma in search of prognostic markers", Histopathology, 46, pp.622~634 (2005)
- Saedon H, "An unusual presentation of Merkel cell carcinoma of the eyelid", Orbit, 27, pp.331~333 (2008)
- Leibovitch I, "An unusual presentation of periocular Merkel cell carcinoma", J Cutan Pathol 33 Suppl, 2, pp.39~41 (2006)
- Beer TW, "Merkel cell carcinomas with CK20 negative and CK7 positive immunostaining", J Cutan Pathol, 36, pp.385~386 (2009)