성인 코눈물관 부분폐쇄에서 실리콘관 삽입술 후 마이토마이신 점안의 효과
The Effect of Mitomycin C Instillation after Silicone Intubation in Adult Partial Nasolacrimal Duct Obstruction
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목적: 성인 코눈물관 부분폐쇄 환자에서 실리콘관 삽입술 후 마이토마이신(Mitomycin C) 점안기간에 따른 임상양상의 차이를 알아보고자 하였다. 대상과 방법: 코눈물관 부분폐쇄로 진단된 환자 38명 61안을 대상으로 실리콘관 삽입술 후 0.04% 마이토마이신 안약을 점안하였다. 점안 기간에 따라 점안하지 않음(A군), 1주 사용(B군), 2주 사용(C군), 3주 사용(D군)으로 분류하여 네 군 사이의 임상양상을 의무기록을 통해 후향적으로 분석하였다. 결과: 전체환자 중 눈물흘림이 호전된 경우가 50안(81.9%), 호전이 없는 경우가 11안(18.1%)이었다. 증상의 호전을 보이는 경우는 A군중 15안(71.4%), B군 중 8안(72.7%), C군 중 13안(86.7%), D군 중 14안(100.0%)이었다. D군, C군, B군, A군의 순서대로 성공률이 높았으며 통계적으로 유의한 결과를 보였다(p=0.025). 결론: 코눈물관 부분폐쇄로 진단된 환자에서 실리콘관 삽입술은 효과가 비교적 좋은 치료방법이며, 술 후 마이토마이신 안약 점안이수술 성공률을 높이는 데 도움이 될 것으로 생각한다.
Abstract
Purpose: To compare the result of mitomycin C (MMC) instillation after silicone intubation in partial nasolacrimal duct obstruction in adults according to duration of instillation. Methods: An instillation of 0.04% MMC eyedrops was performed on 61 eyes of 38 patients diagnosed with partial nasolacrimal duct obstruction. The clinical result of patient groups, classified according to duration of MMC eyedrops instillation,was analyzed prospectively. The patients groups was as follows: no MMC eyedrop instillation (group A), 1 week of MMC instillation (group B), 2 weeks of MMC instillation (group C), and 3 weeks of MMC instillation (group D). Results: Among all patients, 50 eyes (81.9%) showed improved symptoms. Fifteen eyes (71.4%) in group A, 8 eyes (72.7%) in group B, 13 eyes (86.7%) in group C and 14 eyes (100.0%) in group D had a successful outcome. The success rate was observed in groups D, C, B, and A, in descending order, which was statistically significant (p = 0.025). Conclusions: Silicone intubation is an effective treatment option for partial nasolacrimal duct obstruction in adults and MMC eyedrop instillation may improve silicone intubation results.
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