한국 소아의 정상안에서 빛간섭단층혈관조영술을 이용한 황반부 혈관 분석
Macular Microvasculature Features of the Eyes of Healthy Korean Children Using Optical Coherence Tomography Angiography
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목적: 한국 소아의 정상안에서 빛간섭단층혈관조영술을 이용하여 황반 미세혈관구조에 대해 분석하고 나이에 따른 표준자료를 얻고자 하였다. 대상과 방법: 3-15세 이하의 소아 68명(126안)을 대상으로 의무기록을 후향적으로 분석하였다. 황반을 중심으로 한 3-mm2 면적에 대한 빛간섭단층혈관조영술을 시행하였다. 표층 및 심부모세혈관총의 혈관밀도와 망막중심오목무혈관부위 면적을 측정하여 나이군별로 나누어 분석하였다. 나이, 성별, 안축장 및 구면렌즈대응치와의 상관관계를 비교 분석하였다. 결과: 나이군에 따라 3-5, 6-8, 9-11, 그리고 12-15세로 나누어 비교하였을 때 표층모세혈관총 중심오목혈관밀도는 각각 17.41 ± 5.41, 20.53 ± 4.76, 21.78 ± 5.73, 그리고 22.95 ± 3.91%였다. 심부모세혈관총 중심오목혈관밀도는 각각 30.20 ± 6.59, 34.54 ± 7.16, 35.81 ± 6.02, 그리고 37.38 ± 5.16%로 통계적으로 유의한 차이를 보였다(p=0.002, p＜0.001). 안축장은 표층모세혈관총과 심부모세혈관총의 중심오목 혈관밀도와는 양의 상관관계(R2=0.153, p＜0.001; R2=0.158, p＜0.001), 망막중심오목무혈관부위 면적과는 음의 상관관계를 보였다(R2=0.085, p＜0.001). 결론: 한국 소아의 정상안에서 빛간섭단층혈관조영술로 측정한 표층 및 심부모세혈관총의 혈관밀도는 나이군별 차이가 있었으며, 안축장과 유의한 상관관계를 보였다.
Abstract
Purpose: We used optical coherence tomography angiography to analyze the macular microvasculature of normal eyes of healthy Korean children; we derived normative data stratified by age. Methods: We retrospectively analyzed the medical records of 68 children (126 eyes) aged from 3 to 15 years. Optical coherence tomography angiography was performed on 3-mm2 regions centered on the fovea. The vascular densities of the superficial and deep capillary plexuses and the foveal avascular zone were determined, and analyzed by age. We sought correlations between age, gender, axial length, and the spherical equivalent. Results: The foveal, superficial capillary plexus vessel densities were 17.41 ± 5.41, 20.53 ± 4.76, 21.78 ± 5.73, and 22.95 ± 3.91% in children aged 3-5, 6-8, 9-11, and 12-15 years, respectively. The vessel densities of the foveal deep capillary plexus were 30.20 ± 6.59, 34.54 ± 7.16, 35.81 ± 6.02, and 37.38 ± 5.16% in those aged 3-5, 6-8, 9-11, and 12-15 years, respectively. Significant differences by age were apparent (p = 0.002, p < 0.001, respectively). The foveal vessel densities of the superficial and deep capillary plexuses were positively correlated with axial length (R2 = 0.153, p < 0.001; R2 = 0.158, p < 0.001, respectively) and the foveal avascular zone area was negatively correlated with axial length (R2 = 0.085, p < 0.001). Conclusions: The vessel densities of the superficial and deep capillary plexuses measured via optical coherence tomography angiography in normal eyes of healthy Korean children differed by age, and correlated significantly with axial length.
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