한국인의 스펙트럼영역빛간섭단층촬영 변수의 나이에 따른 차이
Age-Related Differences of Spectral-Domain Optical Coherence Tomography Data in Koreans
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초록
목적: 정상 한국인의 시신경유두주위 망막신경섬유층 두께와 시신경유두 변수의 나이에 따른 차이와 상관관계를 알아보고자 하였다. 대상과 방법: 스펙트럼 영역 빛간섭단층촬영술 이용하여 20세부터 70세에 이르는 정상인 128명의 시신경유두주위 망막신경섬유층 두께및 시신경유두 변수를 검사하였다. 결과: 평균 시신경유두 주위의 망막신경섬유층 두께는 나이에 따라 감소하는 것으로 나타났다. 아래쪽 사분면의 망막신경섬유층이 나머지 사분면 영역에 비해 유의하게 두꺼웠다. 평균 시신경유두함몰비와 수직 시신경유두함몰비는 모두 나이에 따라 증가하는 경향을보였으며, 평균 유두함몰비는 r=0.249, 수직 유두함몰비는 r=0.537의 상관계수를 보였다. 그러나 신경테면적, 유두면적, 유두함몰면적은 연령증가와는 무관한 것으로 나타났다. 결론: 평균 시신경유두 주위의 망막신경섬유층 두께는 나이에 따라 감소하는 경향을, 평균 시신경유두함몰비와 수직 시신경유두함몰비는 모두 나이에 따라 증가하는 경향을 보였으며, 수직 유두함몰비가 나이증가와 더 강한 상관성을 보이는 것으로 분석되었다.
Abstract
Purpose: We evaluated the thickness of RNFL and optic nerve head parameters with age in normal eyes using Spectral-Domain Optical Coherence Tomography (SD-OCT). Methods: A total of 128 normal Korean volunteers in different age groups were recruited (age range, 20-70 years). Results: A significant negative correlation in average RNFL thickness with increasing age was found. The inferior areas (130.31 ± 3.33 μm) were significantly thicker than other areas (superior area 119.05 ± 2.12 μm, nasal area 71.80 ± 0.57 μm,temporal area 77.72 ± 0.16 μm). The average C/D ratios (mean 0.38 ± 0.14) and vertical C/D ratios (mean 0.35 ± 0.11) both showed significant increases with age, and the vertical C/D ratio correlation coefficient was higher (average C/D ratio r =0.249, vertical C/D ratio r = 0.537). However, rim area, disc area, and cup volume were not correlated with age. Conclusions: From these findings, we conclude that, in normal Koreans, the mean RNFL thickness decreases and the C/D ratio increases with age, with the increase in the vertical C/D ratio being greater.
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