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인후두 역류질환의 최근 경향

Recent Trends of Laryngopharyngeal Reflux Disease

이상혁|허세형
대한이비인후과학회 (Korean Society of Otorhinolaryngology-Head and Neck Surgery)|2011.08|대한이비인후과학회지 두경부외과학 (Korean Journal of Otorhinolaryngology-Head and Neck Surgery)|제54권 제8호|pp. 519-525

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주제분류이비인후과학

초록

Laryngopharyngeal reflux disease (LPRD) refers to the retrograde flow of gastric content to the laryngopharynx, where it comes in contact with tissues of the upper aerodigestive tract. In Korea, up to 1 out of every 5 patients who visit otorhinolaryngology clinic is supposed to have LPRD with symptoms and physical findings. In the absence of definite diagnostic criteria, LP-RD is suspected when the history and laryngoscopy findings are suggestive of the diagnosis. A diagnosis of LPRD is usually based on response of symptoms to empirical treatment. Most patients with LPRD are treated with proton pump inhibitor with education of life style modification, but there is still little or no solid evidence on the treatment as well as the diagnosis. Failure to respond to a usual treatment suggests the need for confirmatory studies and con-sideration of alternative diagnoses. LPRD appears to be a common but controversial disorder, with conflicting data on pathophysiology, diagnosis, and treatment. Whereas trends are observed and many clinical practices are accepted widely on the basis of experience, we need definitive, prospective, evidence-based studies. In this article, we will review current concept of diagnosis and treatment of LPRD.

Abstract

Laryngopharyngeal reflux disease (LPRD) refers to the retrograde flow of gastric content to the laryngopharynx, where it comes in contact with tissues of the upper aerodigestive tract. In Korea, up to 1 out of every 5 patients who visit otorhinolaryngology clinic is supposed to have LPRD with symptoms and physical findings. In the absence of definite diagnostic criteria, LP-RD is suspected when the history and laryngoscopy findings are suggestive of the diagnosis. A diagnosis of LPRD is usually based on response of symptoms to empirical treatment. Most patients with LPRD are treated with proton pump inhibitor with education of life style modification, but there is still little or no solid evidence on the treatment as well as the diagnosis. Failure to respond to a usual treatment suggests the need for confirmatory studies and con-sideration of alternative diagnoses. LPRD appears to be a common but controversial disorder, with conflicting data on pathophysiology, diagnosis, and treatment. Whereas trends are observed and many clinical practices are accepted widely on the basis of experience, we need definitive, prospective, evidence-based studies. In this article, we will review current concept of diagnosis and treatment of LPRD.

참고문헌 (69)

  1. 김영모, "인·후두 역류증의 치료", 대한이비인후과학회지 두경부외과학, 45(9), pp.835~838 (2002), 대한이비인후과학회
  2. 정만기, "인후두 역류증에 대한 초치료로서 양성자 펌프 억제제4주 단기 치료의 효과", 대한이비인후과학회지 두경부외과학, 48(6), pp.796~800 (2005), 대한이비인후과학회
  3. Choi HS, "Laryngopharyngeal reflux disease. The 2ND disgestive disease research lecture", Korea University Digestive research institute, pp.25~32 (1999)
  4. Dent J, "Mechanism of gastroesophageal reflux in recumbent asymptomatic human subjects", J Clin Invest, 65(2), pp.256~267 (1980)
  5. Schreiber S, "Pathophysiological mechanisms of extraesophageal reflux in otolaryngeal disorders", Eur Arch Otorhinolaryngol, 266(1), pp.17~24 (2009)
  6. Adhami T, "The role of gastric and duodenal agents in laryngeal injury:an experimental canine model", Am J Gastroenterol, 99(11), pp.2098~2106 (2004)
  7. Koufman JA, "The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury", Laryngoscope, 101(4 pt 2 Suppl 53), pp.1~78 (1991)
  8. Johnston N, "Pepsin and carbonic anhydrase isoenzyme III as diagnostic markers for laryngopharyngeal reflux disease", Laryngoscope, 114(12), pp.2129~34 (2004)
  9. Barry DW, "Laryngopharyngeal reflux:more questions than answers", Cleve Clin J Med, 77(5), pp.327~334 (2010)
  10. Vaezi MF, "Laryngeal signs and symptoms and gastroesophageal reflux disease(GERD):a critical assessment of cause and effect association", Clin Gastroenterol Hepatol, 1(5), pp.333~344 (2003)
  11. Vaezi MF, "Therapy insight:gastroesophageal reflux disease and laryngopharyngeal reflux", Nat Clin Pract Gastroenterol Hepatol, 2(12), pp.595~603 (2005)
  12. Farrokhi F, "Extra-esophageal manifestations of gastroesophageal reflux", Oral Dis, 13(4), pp.349~359 (2007)
  13. Koufman JA, "Laryngopharyngeal reflux is different from classic gastroesophageal reflux disease", Ear Nose Throat J, 81(9 suppl 2), pp.7~9 (2002)
  14. Koufman JA, "Prevalence of reflux in 113 consecutive patients with laryngeal and voice disorders", Otolaryngol Head Neck Surg, 123(4), pp.385~388 (2000)
  15. Milstein CF, "Prevalence of laryngeal irritation signs associated with reflux in asymptomatic volunteers:impact of endoscopic technique(rigid vs.flexible laryngoscope)", Laryngoscope, 115(12), pp.2256~2261 (2005)
  16. Branski RC, "The reliability of the assessment of endoscopic laryngeal findings associated with laryngopharyngeal reflux disease", Laryngoscope, 112(6), pp.1019~1024 (2002)
  17. Belafsky PC, "The validity and reliability of the reflux finding score(RFS)", Laryngoscope, 111(8), pp.1313~1317 (2001)
  18. Gupta R, "Laryngopharyngeal reflux:current concepts and questions", Curr Opin Otolaryngol Head Neck Surg, 17(3), pp.143~148 (2009)
  19. Jamieson JR, "Ambulatory 24-h esophageal pH monitoring:normal values,optimal thresholds,specificity,sensitivity,and reproducibility", Am J Gastroenterol, 87(9), pp.1102~1111 (1992)
  20. Reichel O, "Impact of different pH thresholds for 24-hour dual probe pH monitoring in patients with suspected laryngopharyngeal reflux", J Laryngol Otol, 122(5), pp.485~489 (2008)
  21. Shaker R, "Esophagopharyngeal distribution of refluxed gastric acid in patients with reflux laryngitis", Gastroenterology, 109(5), pp.1575~1582 (1995)
  22. Jacob P, "Proximal esophageal pH-metry in patients with"reflux laryngitis"", Gastroenterology, 100(2), pp.305~10 (1991)
  23. Eubanks TR, "Pharyngeal pH monitoring in 222 patients with suspected laryngeal reflux", J Gastrointest Surg, 5(2), pp.183~190 (2001)
  24. Vaezi MF, "Gastroesophageal reflux disease and the larynx", J Clin Gastroenterol, 36(3), pp.198~203 (2003)
  25. Ulualp SO, "Outcomes of acid suppressive therapy in patients with posterior laryngitis", Otolaryngol Head Neck Surg, 124(1), pp.16~22 (2001)
  26. Pritchett JM, "Efficacy of esophageal impedance", pH monitoring in patients with refractory gastroesophageal reflux disease,on and off therapy, 2009, pp.7(7), 743~748
  27. Katz PO, "Medical therapy of supraesophageal gastroesophageal reflux disease", Am J Med, 108(Suppl 4a), pp.170S~177S (2000)
  28. Steward DL, "Proton pump inhibitor therapy for chronic laryngopharyngitis:a randomized placebo-control trial", Otolaryngol Head Neck Surg, 131(4), pp.342~350 (2004)
  29. Ford CN, "Evaluation and management of laryngopharyngeal reflux", JAMA, 294(12), pp.1534~1540 (2005)
  30. Berardi RR, "A critical evaluation of proton pump inhibitors in the treatment of gastroesophageal reflux disease", Am J Manag Care, 6(9 Suppl), pp.S491~S505 (2000)
  31. Williams RB, "Predictors of outcome in an open label,therapeutic trial of high-dose omeprazole in laryngitis", Am J Gastroenterol, 99(5), pp.777~785 (2004)
  32. Fass R, "Empirical trials in treatment of gastroesophageal reflux disease", Dig Dis, 18(1), pp.20~26 (2000)
  33. Richards DA, "Comparative pharmacodynamics and pharmacokinetics of cimetidine and ranitidine", J Clin Gastroenterol, 5(Suppl 1), pp.81~90 (1983)
  34. Fackler WK, "Long-term effect of H2RA therapy on nocturnal gastric acid breakthrough", Gastroenterology, 122(3), pp.625~632 (2002)
  35. de Caestecker J, "Prokinetics and reflux:a promise unfulfilled", Eur J Gastroenterol Hepatol, 14(1), pp.5~7 (2002)
  36. Kahrilas PJ, "The effects of tegaserod(HTF 919)on oesophageal acid exposure in gastro-oesophageal reflux disease", Aliment Pharmacol Ther, 14(11), pp.1503~1509 (2000)
  37. Castell DO, "Future medical therapy of reflux esophagitis", J Clin Gastroenterol, 8(Suppl 1), pp.81~85 (1986)
  38. Storr M, "Pathophysiology and pharmacological treatment of gastroesophageal reflux disease", Dig Dis, 18(2), pp.93~102 (2000)
  39. Hopkins C, "Acid reflux treatment for hoarseness", Cochrane Database Syst Rev, (1), pp.CD005054~ (2006)
  40. Fuchs KH, "Laparoscopic Nissen repair:indications,techniques and long-term benefits", Langenbecks Arch Surg, 390(3), pp.197~202 (2005)
  41. Oelschlager BK, "Symptomatic and physiologic outcomes after operative treatment for extraesophageal reflux", Surg Endosc, 16(7), pp.1032~1036 (2002)
  42. Vaezi MF, "Extraesophageal manifestations of gastroesophageal reflux disease", Clin Cornerstone, 5(4), pp.32~38 (2003)
  43. Swoger J, "Surgical fundoplication in laryngeal reflux unresponsive to aggressive acid suppression:a controlled study", Clin Gastroenterol Hepatol, 4(4), pp.433~441 (2006)
  44. Park W, "Laryngopharyngeal reflux:prospective cohort study evaluating optimal dose of proton-pump inhibitor therapy and pretherapy predictors of response", Laryngoscope, 115(7), pp.1230~1238 (2005)
  45. Noordzij JP, "Evaluation of omeprazole in the treatment of reflux laryngitis:a prospective,placebo-controlled,randomized,double-blind study", Laryngoscope, 111(12), pp.2147~2151 (2001)
  46. Eherer AJ, "Effect of pantoprazole on the course of reflux-associated laryngitis:a placebocontrolled double-blind crossover study", Scand J Gastroenterol, 38(5), pp.462~467 (2003)
  47. El Serag HB, "Lansoprazole treatment of patients with chronic idiopathic laryngitis:a placebo-controlled trial", Am J Gastroenterol, 96(4), pp.979~983 (2001)
  48. Vaezi MF, "Treatment of chronic posterior laryngitis with esomeprazole", Laryngoscope, 116(2), pp.254~260 (2006)
  49. Qadeer MA, "Proton pump inhibitor therapy for suspected GERD-related chronic laryngitis:a meta analysis of randomized controlled trials", Am J Gastroenterol, 101(11), pp.2646~2654 (2006)
  50. Shaw GY, "Laryngeal manifestations of gastroesophageal reflux before and after treatment with omeprazole", South Med J, 90(11), pp.1115~1122 (1997)
  51. Wilder-Smith CH, "Tolerance to oral H2 receptor antagonist", Dig Dis Sci, 35(8), pp.976~983 (1990)
  52. Reichel O, "Double-blind,placebo-controlled trial with esomeprazole for symptoms and signs associated with laryngopharyngeal reflux", Otolaryngol Head Neck Surg, 139(3), pp.414~420 (2008)
  53. Lam PK, "Rabeprazole is effective in treating laryngopharyngeal reflux in a randomized placebo-controlled trial", Clin Gastroentrol Hepatol, 8(9), pp.770~776 (2010)
  54. Fiocca R, "Long-term outcome of microscopic esophagitis in chronic GERD patients treated with esomeprazole or laparoscopic antireflux surgery in the LOTUS trial", Am J Gastroenterol, 105(5), pp.1015~23 (2010)
  55. Jalving M, "Increased risk of fundic gland polyps during long-term proton pump inhibitor therapy", Aliment Pharmacol Ther, 24(9), pp.1341~1348 (2006)
  56. Bruley des Varannes S, "Short and long-term PPI treatment for GERD. Do we need more-potent anti-secretory drugs", est Pract Res Clin Gastroenterol, 24(6), pp.905~921 (2010)
  57. Yang YX, "Long-term proton pump inhibitor therapy and risk of hip fracture", JAMA, 296(24), pp.2947~53 (2006)
  58. Merriman NA, "Hip fracture risk in patients with a diagnosis of pernicious anemia", Gastroenterology, 138(4), pp.1330~1337 (2010)
  59. Gray SL, "Proton pump inhibitor use,hip fracture,and change in bone mineral density in postmenopausal women:results Women’s Health Initiative", Arch Intern Med, 170(9), pp.765~771 (2010)
  60. Dalton BR, "Proton pump inhibitors increase significantly the risk of Clostridium difficile infection in a low-endemicity,non-outbreak hospital setting", Aliment Pharmacol Ther, 29(6), pp.626~634 (2009)
  61. Howell MD, "Iatrogenic gastric acid suppression and the risk of nosocomial Clostridium difficile infection", Arch Intern Med, 170(9), pp.784~790 (2010)
  62. Linsky A, "Proton pump inhibitors and risk for recurrent Clostridium difficile infection", Arch Intern Med, 170(9), pp.772~778 (2010)
  63. Bateman DN, "Mortality study of 18,000 patients treated with omeprazole", Gut, 52(7), pp.942~946 (2003)
  64. Diav-Citrin O, "The safety of proton pump inhibitors in pregnancy:a multicentre prospective controlled study", Aliment Pharmacol Ther, 21(3), pp.269~275 (2005)
  65. Lee JK, "Current trends in diagnosis and management of laryngopharyngeal reflux disease; a survey of Korean otolaryngologists", J Korean Soc Logoped Phoniatr, 20(2), pp.141~147 (2009)
  66. Lee YS, "Prospective,observational study using rabeprazole in 455 patients with laryngopharyngeal reflux disease", Eur Arch Otorhinolaryngol, 268(6), pp.863~869 (2011)
  67. Hanson DG, "Diagnosis and management of chronic laryngitis associated with reflux", Am J Med, 108(Suppl 4a), pp.112S~119S (2000)
  68. Koufman J, "Laryngopharyngeal reflux: consensus conference report", J Voice, 10(3), pp.215~216 (1996)
  69. Reavis KM, "Laryngopharyngeal reflux symptoms better predict the presence of esophageal adenocarcinoma than typical gastroesophageal reflux symptoms", Ann Surg, 239(6), pp.849~856 (2004)

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