여포 변이 유두 갑상선암: 임상 양상과 예후
Follicular Variant of Papillary Thyroid Carcinoma:Clinical Manifestation and Prognosis
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Background and Objectives Despite relatively high incidences of follicular variant of papillary thyroid carcinoma (FV-PTC), there is a continuous debate regarding the clinical behavior, treatment outcome, prognostic variables and survival of this disease. We performed this study for the purpose of getting further understanding and more supporting ideas for the treatment of FV-PTC. Subjects and Method A clinicopathologic analysis of 116 patients who underwent a thyroidectomy with a final diagnosis of FV-PTC divided the patients into three groups: the FV-PTC only group (group A, n=78), the FV-PTC group who developed classical papillary thyroid carcinoma (C-PTC) (group B, n=38) and the C-PTC only (group C, n=320, 2003, Korea Cancer Center Hospital). The three groups were compared with respect to the following various clinicopathological characteristics: age at diagnosis, tumor size, stage of tumor, capsular invasion, age, metastasis, extent, size score, multifocality of tumor, LN metastasis, treatment, and recurrence. Results The mean tumor sizes, disease stage, and type of initial surgery were similar in three groups. However, the prevalence of nodal disease and capsular invasion were significantly higher in the groups B and C compared to the patients of group A. The 8-year disease-free survival rate was 93.7% in the patients with FV-PTC only, 90.4% in the patients with C-PTC only and 88.2% in the patients with FV-PTC group, who developed C-PTC (p >0.05). Conclusion The clinical behavior and prognosis of PTC and FV-PTC groups did not differ significantly. In treating FV-PTC, we find that it is desirable to choose a similar strategy as that used to treat C-PTC.
Abstract
Background and Objectives Despite relatively high incidences of follicular variant of papillary thyroid carcinoma (FV-PTC), there is a continuous debate regarding the clinical behavior, treatment outcome, prognostic variables and survival of this disease. We performed this study for the purpose of getting further understanding and more supporting ideas for the treatment of FV-PTC. Subjects and Method A clinicopathologic analysis of 116 patients who underwent a thyroidectomy with a final diagnosis of FV-PTC divided the patients into three groups: the FV-PTC only group (group A, n=78), the FV-PTC group who developed classical papillary thyroid carcinoma (C-PTC) (group B, n=38) and the C-PTC only (group C, n=320, 2003, Korea Cancer Center Hospital). The three groups were compared with respect to the following various clinicopathological characteristics: age at diagnosis, tumor size, stage of tumor, capsular invasion, age, metastasis, extent, size score, multifocality of tumor, LN metastasis, treatment, and recurrence. Results The mean tumor sizes, disease stage, and type of initial surgery were similar in three groups. However, the prevalence of nodal disease and capsular invasion were significantly higher in the groups B and C compared to the patients of group A. The 8-year disease-free survival rate was 93.7% in the patients with FV-PTC only, 90.4% in the patients with C-PTC only and 88.2% in the patients with FV-PTC group, who developed C-PTC (p >0.05). Conclusion The clinical behavior and prognosis of PTC and FV-PTC groups did not differ significantly. In treating FV-PTC, we find that it is desirable to choose a similar strategy as that used to treat C-PTC.
참고문헌 (17)
- Lin HW, "Clinical behavior of follicular variant of papillary thyroid carcinoma:presentation and survival", Laryngoscope, 120(4), pp.712~716 (2010)
- Liu J, "Follicular variant of papillary thyroid carcinoma:a clinicopathologic study of problematic entity", Cancer, 107(6), pp.1255~1264 (2006)
- Zidan J, "Pure versus follicular variant of papillary thyroid carcinoma:clinical features,prognostic factors,treatment,and survival", Cancer, 97(5), pp.1181~1185 (2003)
- Yuksel O, "The relation between pure papillary and follicular variant in papillary thyroid carcinoma", Endocr Regul, 42(1), pp.29~33 (2008)
- Lang BH, "Classical and follicular variant of papillary thyroid carcinoma:a comparative study on clinicopathologic features and long-term outcome", World J Surg, 30(5), pp.752~758 (2006)
- Burningham AR, "Papillary and follicular variant of papillary carcinoma of the thyroid:initial presentation and response to therapy", Otolaryngol Head Neck Surg, 132(6), pp.840~844 (2005)
- 이승철, "소포 변이 유두 갑상선암(Follicular Variant Papillary Thyroid Carcinoma): 임상 소견과 수술 치료 전략", 대한외과학회지, 73(5), pp.366~371 (2007), 대한외과학회
- Tielens ET, "Follicular variant of papillary thyroid carcinoma.A clinicopathologic study", Cancer, 73(2), pp.424~431 (1994)
- Passler C, "Follicular variant of papillary thyroid carcinoma:a long term follow-up", Arch Surg, 138(12), pp.1362~1366 (2003)
- Goodell WM, "Fine-needle aspiration diagnosis of the follicular variant of papillary carcinoma", Cancer, 84(6), pp.349~354 (1998)
- Baloch ZW, "Follicular variant of papillary carcinoma.Cytologic and histologic correlation", Am J Clin Pathol, 111(2), pp.216~222 (1999)
- 성낙윤, "갑상선 고분화 암종의 재발 양상에 대한 고찰", 대한이비인후과학회지 두경부외과학, 46(10), pp.868~873 (2003), 대한이비인후과학회
- LiVolsi VA, "The demise of follicular carcinoma of the thyroid gland", Thyroid, 4(2), pp.233~236 (1994)
- Carcangiu ML, "Papillary carcinoma of the thyroid.A clinicopathologic study of 241 cases treated at the University of Florence,Italy", Cancer, 55(4), pp.805~828 (1985)
- Baloch ZW, "Follicular-patterned lesions of the thyroid:the bane of the pathologist", Am J Clin Pathol, 117(1), pp.143~150 (2002)
- Chang HY, "Clinical presentations and outcomes of surgical treatment of follicular variant of the papillary thyroid carcinomas", Jpn J Clin Oncol, 36(11), pp.688~693 (2006)
- Elsheikh TM, "Interobserver and intraobserver variation among experts in the diagnosis of thyroid follicular lesions with borderline nuclear features of papillary carcinoma", Am J Clin Pathol, 130(5), pp.736~744 (2008)