폴리페놀의 비타민 C 안정성 유지와 피부 침투성 증가에 관한 연구
Enhancement of the Stability and Skin Penetration of Vitamin C by Polyphenol.
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Abstract
Background: It is necessary for human beings to uptake vitamin C through diet or supplements. It is also well-known that vitamin C plays an important role in the prevention of scurvy, enhancement of collagen synthesis and anti-tumor immune response. In addition, there are several recent reports regarding the effective role of vitamin C on the regulation of allergic responses, such as atopic dermatitis and asthma. However, the effective therapeutic and preventive measures using vitamin C are not established yet, since vitamin C is seriously unstable in aqueous solution. Therefore, we have investigated the best way to maintain the stability of vitamin C. Methods: After we making a mixture of polyphenol (0.001, 0.01, 0.1%) and vitamin C (1 mM), the mixtures were placed at room temperature both with/without light protection. And then the concentration of ascorbic acid was measured with HPLC. To analyze the in vivo effect of vitamin C on the regulation of skin allergic reaction, polyphenol (0.1%)-vitamin C (1 mM) mixture was applied to the skin and the production of histamine from mast cell was analyzed by Evans blue dye staining. Results: We have found that the polyphenol has preventive power of oxidation of vitamin C. In addition, the production of histamine was suppressed by the polyphenol (0.1%)-vitamin C (1 mM) mixture. Conclusion: We have reached the conclusion that our study suggests the research guideline for the therapy of atopic dermatitis through vitamin C. (Immune Network 2004;4(4): 250-254)
참고문헌 (22)
- "of vitamin C in humans. Am J Clin Nutr 45", pp.693~703 (1987)
- "Vitamin C and human health--a review of recent data relevant to human requirements.", 66, pp.19~30 (1996)
- "Increased attachment and confluence of skin epidermal cells in culture induced by ascorbic acid detection by permeation of trypan blue across cultured cell layers. Cell Struct Funct 15", pp.143~150 (1990)
- "Ascorbic acid suppresses drug-induced apoptosis in human colon cancer cells by scavenging mitochondrial superoxide anions.", 25, pp.703~712 (2004)
- "Vitamin C downregulates interleukin-18 production by increasing reactive oxygen intermediate and mitogen- activated protein kinase signalling in B16F10 murine melanoma cells.", 13, pp.549~554 (2003)
- "L-ascorbic acid (vitamin C) induces the apoptosis of B16 murine melanoma cells via a caspase-8-independent pathway.", 52, pp.693~698 (2003)
- "Vitamin C regulates keratinocyte viability, epidermal barrier, and basement membrane in vitro, and reduces wound contraction after grafting of cultured skin substitutes", 118, pp.565~572 (2002)
- "Interleukin 18 is a primary mediator of the inflammation associated with dextran sulphate sodium induced colitis: blocking interleukin 18 attenuates intestinal damage", 50, pp.812~820 (2002)
- "Vitamin C supplementation for asthma." (2004)
- "Antihistamine effect of supplemental ascorbic acid and neutrophil chemotaxis. J Am Coll Nutr 11", pp.172~176 (1992)
- "Vitamin C in breast milk may reduce the risk of atopy in the infant.", 59, pp.123~128 (2005)
- "Oxidative decomposition of vitamin C in drinking water.", 38, pp.855~860 (2004)
- "Ascorbic acid prevents the dose-dependent inhibitory effects of polyphenols and phytates on nonheme-iron absorption. Am J Clin Nutr 53", pp.537~541 (1991)
- "Superoxide anion production by alveolar macrophages of guinea pigs fed different diets in a model of atopy. Agents Actions 23", pp.99~100 (1988)
- "Combination treatment of vitamin C and desferrioxamine suppresses glomerular superoxide and prostaglandin E production in diabetic rats.", 7, pp.106~109 (2005)
- "The stabilization of L-ascorbic acid in aqueous solution and water-in-oil-in-water double emulsion by controlling pH and electrolyte concentration.", 55, pp.1~12 (2004)
- "Functional analysis of histamine release from basophils and mast cells in subjects with the Ile-181→Leu variant of Fc epsilon RI-beta.", 93, pp.279~286 (1997)
- "Identification of allergic disease among users of antihistamines.", 10, pp.234~238 (2004)
- "Reversal by ascorbic acid of suppression by endogenous histamine of rat lymphocyte blastogenesis.", 118, pp.639~644 (1988)
- "Alterations of vitamin C and antioxidant capacity as affected by processing tomatoes to different products.", 51(lics), pp.7962~7968 (2003)
- "Modulating factors of radical intensity and cytotoxic activity of ascorbate ( review)", 17, pp.3513~3520 (1997)
- "Ascorbic acid prevents the dose-dependent inhibitory effects of polyphenols and phytates on nonheme-iron absorption. Am J Clin Nutr 53", pp.537~541 (1991)