Extracellular Vesicles of Neutrophils
5
조회
0
다운로드
3
인용
0
참고문헌
키워드
초록
Extracellular vesicles (EVs) are membrane-derived vesicles that mediate intercellular communications. As professional phagocytes, neutrophils also produce EVs in response to various inflammatory stimuli during inflammatory processes. Neutrophil-derived EVs can be categorized into 2 subtypes according to the mechanism of generation. Neutrophil-derived trails (NDTRs) are generated from migrating neutrophils. The uropods of neutrophils are elongated by adhesion to endothelial cells, and small parts of the uropods are detached, leaving submicrometer-sized NDTRs. Neutrophil-derived microvesicles (NDMVs) are generated from neutrophils which arrived at the inflammatory foci. Membrane blebbing occurs in response to various stimuli at the inflammatory foci, and small parts of the blebs are detached from the neutrophils, leaving NDMVs. These 2 subtypes of neutrophil-derived EVs share common features such as membrane components, receptors, and ligands. However, there are substantial differences between these 2 neutrophil-derived EVs. NDTRs exert pro-inflammatory functions by guiding subsequent immune cells through the inflammatory foci. On the other hand, NDMVs exert anti-inflammatory functions by limiting the excessive immune responses of nearby cells. This review outlines the current understanding of the different subtypes of neutrophil-derived EVs and provides insights into the clinical relevance of neutrophil-derived EVs.
Abstract
Extracellular vesicles (EVs) are membrane-derived vesicles that mediate intercellular communications. As professional phagocytes, neutrophils also produce EVs in response to various inflammatory stimuli during inflammatory processes. Neutrophil-derived EVs can be categorized into 2 subtypes according to the mechanism of generation. Neutrophil-derived trails (NDTRs) are generated from migrating neutrophils. The uropods of neutrophils are elongated by adhesion to endothelial cells, and small parts of the uropods are detached, leaving submicrometer-sized NDTRs. Neutrophil-derived microvesicles (NDMVs) are generated from neutrophils which arrived at the inflammatory foci. Membrane blebbing occurs in response to various stimuli at the inflammatory foci, and small parts of the blebs are detached from the neutrophils, leaving NDMVs. These 2 subtypes of neutrophil-derived EVs share common features such as membrane components, receptors, and ligands. However, there are substantial differences between these 2 neutrophil-derived EVs. NDTRs exert pro-inflammatory functions by guiding subsequent immune cells through the inflammatory foci. On the other hand, NDMVs exert anti-inflammatory functions by limiting the excessive immune responses of nearby cells. This review outlines the current understanding of the different subtypes of neutrophil-derived EVs and provides insights into the clinical relevance of neutrophil-derived EVs.
참고문헌 (41)
- Théry C, "Membrane vesicles as conveyors of immune responses", Nat Rev Immunol, 9, pp.581~593 (2009)
- van der Pol E, "Recent developments in the nomenclature, presence, isolation, detection and clinical impact of extracellular vesicles", J Thromb Haemost, 14, pp.48~56 (2016)
- György B, "Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles", Cell Mol Life Sci, 68, pp.2667~2688 (2011)
- Loyer X, "Microvesicles as cell-cell messengers in cardiovascular diseases", Circ Res, 114, pp.345~353 (2014)
- Stein JM, "Ectocytosis caused by sublytic autologous complement attack on human neutrophils. The sorting of endogenous plasma-membrane proteins and lipids into shed vesicles", Biochem J, 274, pp.381~386 (1991)
- Hess C, "Ectosomes released by human neutrophils are specialized functional units", J Immunol, 163, pp.4564~4573 (1999)
- Eken C, "Ectosomes of polymorphonuclear neutrophils activate multiple signaling pathways in macrophages", Immunobiology, 218, pp.382~392 (2013)
- Eken C, "Ectosomes released by polymorphonuclear neutrophils induce a MerTK-dependent anti-inflammatory pathway in macrophages", J Biol Chem, 285, pp.39914~39921 (2010)
- Duarte TA, "Mycobacterium tuberculosis-induced neutrophil ectosomes decrease macrophage activation", Tuberculosis (Edinb), 92, pp.218~225 (2012)
- Gasser O, "Characterisation and properties of ectosomes released by human polymorphonuclear neutrophils", Exp Cell Res, 285, pp.243~257 (2003)
- Pliyev BK, "Neutrophil microparticles modulate cytokine production by natural killer cells", Cytokine, 65, pp.126~129 (2014)
- Gasser O, "Microparticles released by human neutrophils adhere to erythrocytes in the presence of complement", Exp Cell Res, 307, pp.381~387 (2005)
- Kambas K, "Tissue factor expression in neutrophil extracellular traps and neutrophil derived microparticles in antineutrophil cytoplasmic antibody associated vasculitis may promote thromboinflammation and the thrombophilic state associated with the disease", Ann Rheum Dis, 73, pp.1854~1863 (2014)
- Pluskota E, "Expression, activation, and function of integrin alphaMbeta2 (Mac-1) on neutrophil-derived microparticles", Blood, 112, pp.2327~2335 (2008)
- Mesri M, "Leukocyte microparticles stimulate endothelial cell cytokine release and tissue factor induction in a JNK1 signaling pathway", J Biol Chem, 274, pp.23111~23118 (1999)
- Slater TW, "Neutrophil microparticles deliver active myeloperoxidase to injured mucosa to inhibit epithelial wound healing", J Immunol, 198, pp.2886~2897 (2017)
- Nolan S, "Nitric oxide regulates neutrophil migration through microparticle formation", Am J Pathol, 172, pp.265~273 (2008)
- Pitanga TN, "Neutrophil-derived microparticles induce myeloperoxidase-mediated damage of vascular endothelial cells", BMC Cell Biol, 15, pp.21~ (2014)
- Hong Y, "Anti-neutrophil cytoplasmic antibodies stimulate release of neutrophil microparticles", J Am Soc Nephrol, 23, pp.49~62 (2012)
- Nieuwland R, "Cellular origin and procoagulant properties of microparticles in meningococcal sepsis", Blood, 95, pp.930~935 (2000)
- Dalli J, "Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles", Blood, 112, pp.2512~2519 (2008)
- Prakash PS, "Human microparticles generated during sepsis in patients with critical illness are neutrophil-derived and modulate the immune response", J Trauma Acute Care Surg, 73, pp.401~406 (2012)
- Mesri M, "Endothelial cell activation by leukocyte microparticles", J Immunol, 161, pp.4382~4387 (1998)
- Rhys HI, "Neutrophil microvesicles from healthy control and rheumatoid arthritis patients prevent the inflammatory activation of macrophages", EBioMedicine, 29, pp.60~69 (2018)
- Headland SE, "Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis", Sci Transl Med, 7, pp.315ra190~ (2015)
- Timár CI, "Antibacterial effect of microvesicles released from human neutrophilic granulocytes", Blood, 121, pp.510~518 (2013)
- Lim K, "Neutrophil trails guide influenza-specific CD8+ T cells in the airways", Science, 349, pp.aaa4352~ (2015)
- Dalli J, "Heterogeneity in neutrophil microparticles reveals distinct proteome and functional properties", Mol Cell Proteomics, 12, pp.2205~2219 (2013)
- Gasser O, "Activated polymorphonuclear neutrophils disseminate anti-inflammatory microparticles by ectocytosis", Blood, 104, pp.2543~2548 (2004)
- Eken C, "Polymorphonuclear neutrophil-derived ectosomes interfere with the maturation of monocyte-derived dendritic cells", J Immunol, 180, pp.817~824 (2008)
- Hyun YM, "Uropod elongation is a common final step in leukocyte extravasation through inflamed vessels", J Exp Med, 209, pp.1349~1362 (2012)
- Nauseef WM, "Neutrophils at work", Nat Immunol, 15, pp.602~611 (2014)
- Kowal J, "Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes", Proc Natl Acad Sci U S A, 113, pp.E968~E977 (2016)
- Tkach M, "Why the need and how to approach the functional diversity of extracellular vesicles", Philos Trans R Soc Lond B Biol Sci, 373, pp.20160479~ (2018)
- Tucher C, "Extracellular vesicle subtypes released from activated or apoptotic T-lymphocytes carry a specific and stimulus-dependent protein cargo", Front Immunol, 9, pp.534~ (2018)
- Bang OY, "Cancer cell-derived extracellular vesicles are associated with coagulopathy causing ischemic stroke via tissue factor-independent way: the OASIS-CANCER study", PLoS One, 11, pp.e0159170~ (2016)
- Bebelman MP, "Biogenesis and function of extracellular vesicles in cancer", Pharmacol Ther, 188, pp.1~11 (2018)
- Kim MS, "Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells", Nanomedicine (Lond), 12, pp.655~664 (2016)
- Akao Y, "Microvesicle-mediated RNA molecule delivery system using monocytes", macrophages, 2011, pp.19, 395~399
- Skog J, "Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers", Nat Cell Biol, 10, pp.1470~1476 (2008)
- Silva AK, "Combining magnetic nanoparticles with cell derived microvesicles for drug loading and targeting", Nanomedicine (Lond), 11, pp.645~655 (2015)