Extracellular Mechanisms of Neutrophils in Immune Cell Crosstalk
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초록
Neutrophils are professional phagocytes that provide defense against invading pathogens through phagocytosis, degranulation, generation of ROS, and the formation of neutrophil extracellular traps (NETs). Although long been considered as short-lived effector cells with limited biosynthetic activity, recent studies have revealed that neutrophils actively communicate with other immune cells. Neutrophils employ various types of soluble mediators, including granules, cytokines, and chemokines, for crosstalk with immune cells. Additionally, ROS and NETs, major arsenals of neutrophils, are utilized for intercellular communication. Furthermore, extracellular vesicles play a crucial role as mediators of neutrophil crosstalk. In this review, we highlight the extracellular mechanisms of neutrophils and their roles in crosstalk with other cells.
Abstract
Neutrophils are professional phagocytes that provide defense against invading pathogens through phagocytosis, degranulation, generation of ROS, and the formation of neutrophil extracellular traps (NETs). Although long been considered as short-lived effector cells with limited biosynthetic activity, recent studies have revealed that neutrophils actively communicate with other immune cells. Neutrophils employ various types of soluble mediators, including granules, cytokines, and chemokines, for crosstalk with immune cells. Additionally, ROS and NETs, major arsenals of neutrophils, are utilized for intercellular communication. Furthermore, extracellular vesicles play a crucial role as mediators of neutrophil crosstalk. In this review, we highlight the extracellular mechanisms of neutrophils and their roles in crosstalk with other cells.
참고문헌 (97)
- Borregaard N, "Neutrophils, from marrow to microbes", Immunity, 33, pp.657~670 (2010)
- Nathan C, "Neutrophils and immunity : challenges and opportunities", Nat Rev Immunol, 6, pp.173~182 (2006)
- Nauseef WM, "Neutrophils at work", Nat Immunol, 15, pp.602~611 (2014)
- Tamassia N, "Cytokine production by human neutrophils : revisiting the"dark side of the moon"", Eur J Clin Invest, 48(Suppl 2), pp.e12952~ (2018)
- Tsai CY, "Cross-talk among polymorphonuclear neutrophils, immune, and non-immune cells via released cytokines, granule proteins, microvesicles, and neutrophil extracellular trap formation : a novel concept of biology and pathobiology for neutrophils", Int J Mol Sci, 22, pp.3119~ (2021)
- Lin A, "Granulocytes : new members of the antigen-presenting cell family", Front Immunol, 8, pp.1781~ (2017)
- Mantovani A, "Neutrophils in the activation and regulation of innate and adaptive immunity", Nat Rev Immunol, 11, pp.519~531 (2011)
- 홍장원, "Extracellular Vesicles of Neutrophils", Immune Network, 18(6), pp.1~9 (2018), 대한면역학회[DOI]
- Youn YJ, "Neutrophil-derived trail is a proinflammatory subtype of neutrophil-derived extracellular vesicles", Theranostics, 11, pp.2770~2787 (2021)
- Schuster S, "Crosstalk between neutrophils and dendritic cells : a context-dependent process", J Leukoc Biol, 94, pp.671~675 (2013)
- Wilson AS, "Neutrophil extracellular traps and their histones promote Th17 cell differentiation directly via TLR2", Nat Commun, 13, pp.528~ (2022)
- Fang H, "Neutrophil extracellular traps contribute to immune dysregulation in bullous pemphigoid via inducing B-cell differentiation and antibody production", FASEB J, 35, pp.e21746~ (2021)
- Monteith AJ, "Neutrophil extracellular traps enhance macrophage killing of bacterial pathogens", Sci Adv, 7 (2021)
- Wang H, "Regulatory T-cell and neutrophil extracellular trap interaction contributes to carcinogenesis in non-alcoholic steatohepatitis", J Hepatol, 75, pp.1271~1283 (2021)
- Nadkarni S, "Neutrophils induce proangiogenic T cells with a regulatory phenotype in pregnancy", Proc Natl Acad Sci U S A, 113, pp.E8415~E8424 (2016)
- Gestermann N, "Netting neutrophils activate autoreactive B cells in lupus", J Immunol, 200, pp.3364~3371 (2018)
- Sheshachalam A, "Granule protein processing and regulated secretion in neutrophils", Front Immunol, 5, pp.448~ (2014)
- 홍장원, "Current Understanding in Neutrophil Differentiation and Heterogeneity", Immune Network, 17(5), pp.298~306 (2017), 대한면역학회[DOI]
- Zimmermann M, "Chromatin remodelling and autocrine TNFα are required for optimal interleukin-6 expression in activated human neutrophils", Nat Commun, 6, pp.6061~ (2015)
- Krotova K, "Neutrophil elastase activates mmps in macrophages and promotes adhesion and cytokine expression through the integrin – Srk pathway", J Immunol, 200, pp.102~ (2018)
- Maffia PC, "Neutrophil elastase converts human immature dendritic cells into transforming growth factor-beta1-secreting cells and reduces allostimulatory ability", Am J Pathol, 171, pp.928~937 (2007)
- Odobasic D, "Neutrophil myeloperoxidase regulates T-cell-driven tissue inflammation in mice by inhibiting dendritic cell function", Blood, 121, pp.4195~4204 (2013)
- Strzepa A, "Neutrophil-derived myeloperoxidase facilitates both the induction and elicitation phases of contact hypersensitivity", Front Immunol, 11, pp.608871~ (2021)
- Moriuchi H, "Cathepsin G, a neutrophil-derived serine protease, increases susceptibility of macrophages to acute human immunodeficiency virus type 1 infection", J Virol, 74, pp.6849~6855 (2000)
- Wang F, "Alarmin human α defensin HNP1 activates plasmacytoid dendritic cells by triggering NF-κB and IRF1 signaling pathways", Cytokine, 83, pp.53~60 (2016)
- Lu W, "Pro-inflammatory and pro-apoptotic properties of human defensin 5", Biochem Biophys Res Commun, 436, pp.557~562 (2013)
- Tecchio C, "Neutrophil-derived chemokines on the road to immunity", Semin Immunol, 28, pp.119~128 (2016)
- Tecchio C, "Neutrophil-derived cytokines : facts beyond expression", Front Immunol, 5, pp.508~ (2014)
- Speer CP, "Enhanced release of oxygen metabolites by monocyte-derived macrophages exposed to proteolytic enzymes : activity of neutrophil elastase and cathepsin G", J Immunol, 133, pp.2151~2156 (1984)
- Vonwirth V, "Inhibition of arginase 1 liberates potent T cell immunostimulatory activity of human neutrophil granulocytes", Front Immunol, 11, pp.617699~ (2021)
- Munder M, "Suppression of T-cell functions by human granulocyte arginase", Blood, 108, pp.1627~1634 (2006)
- Wu H, "Arginase-1-dependent promotion of Th17 differentiation and disease progression by MDSCs in systemic lupus erythematosus", Sci Transl Med, 8 (2016)
- Köstlin N, "Granulocytic myeloid-derived suppressor cells accumulate in human placenta and polarize toward a Th2 phenotype", J Immunol, 196, pp.1132~1145 (2016)
- Kandler K, "The anti-microbial peptide LL-37 inhibits the activation of dendritic cells by TLR ligands", Int Immunol, 18, pp.1729~1736 (2006)
- Minns D, "The neutrophil antimicrobial peptide cathelicidin promotes Th17 differentiation", Nat Commun, 12, pp.1285~ (2021)
- Mader JS, "The human cathelicidin, LL-37, induces granzyme-mediated apoptosis in regulatory T cells", J Immunother, 34, pp.229~235 (2011)
- Mader JS, "The human cathelicidin, LL-37, induces granzyme-mediated apoptosis in cytotoxic T lymphocytes", Exp Cell Res, 317, pp.531~538 (2011)
- Yoshida T, "Inhibitory effect of glycyrrhizin on the neutrophil-dependent increase of R5 HIV replication in cultures of macrophages", Immunol Cell Biol, 87, pp.554~558 (2009)
- Bennouna S, "Cross-talk in the innate immune system : neutrophils instruct recruitment and activation of dendritic cells during microbial infection", J Immunol, 171, pp.6052~6058 (2003)
- Suttmann H, "Neutrophil granulocytes are required for effective Bacillus Calmette-Guérin immunotherapy of bladder cancer and orchestrate local immune responses", Cancer Res, 66, pp.8250~8257 (2006)
- Zhou SL, "Tumor-associated neutrophils recruit macrophages and T-regulatory cells to promote progression of hepatocellular carcinoma and resistance to sorafenib", Gastroenterology, 150, pp.1646~1658 (2016)
- Puga I, "B cell-helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen", Nat Immunol, 13, pp.170~180 (2011)
- Bi Y, "IL-17A produced by neutrophils protects against pneumonic plague through orchestrating IFN-γ-activated macrophage programming", J Immunol, 192, pp.704~713 (2014)
- Michaeli J, "Tumor-associated neutrophils induce apoptosis of non-activated CD8 T-cells in a TNFα and NO-dependent mechanism, promoting a tumor-supportive environment", OncoImmunology, 6, pp.e1356965~ (2017)
- Yang W, "Neutrophils promote the development of reparative macrophages mediated by ROS to orchestrate liver repair", Nat Commun, 10, pp.1076~ (2019)
- Pillay J, "A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1", J Clin Invest, 122, pp.327~336 (2012)
- Singel KL, "Mature neutrophils suppress T cell immunity in ovarian cancer microenvironment", JCI Insight, 4, pp.e122311~ (2019)
- Mensurado S, "Tumor-associated neutrophils suppress pro-tumoral IL-17+ γδ T cells through induction of oxidative stress", PLoS Biol, 16, pp.e2004990~ (2018)
- Kuley R, "B cell activating factor(BAFF)from neutrophils and dendritic cells is required for protective B cell responses against Salmonella typhimurium infection", PLoS One, 16, pp.e0259158~ (2021)
- Huard B, "APRIL secreted by neutrophils binds to heparan sulfate proteoglycans to create plasma cell niches in human mucosa", J Clin Invest, 118, pp.2887~2895 (2008)
- Brinkmann V, "Neutrophil extracellular traps kill bacteria", Science, 303, pp.1532~1535 (2004)
- Delgado-Rizo V, "Neutrophil extracellular traps and its implications in inflammation : an overview", Front Immunol, 8, pp.81~ (2017)
- Mutua V, "A review of neutrophil extracellular traps(NETs)in disease : potential anti-nets therapeutics", Clin Rev Allergy Immunol, 61, pp.194~211 (2021)
- Costa S, "Recent advances on the crosstalk between neutrophils and B or T lymphocytes", Immunology, 156, pp.23~32 (2019)
- Sivanandham R, "Neutrophil extracellular trap production contributes to pathogenesis in SIV-infected nonhuman primates", J Clin Invest, 128, pp.5178~5183 (2018)
- Chen X, "Neutrophil extracellular trapping network promotes the pathogenesis of neutrophil-associated asthma through macrophages", Immunol Invest, 50, pp.544~561 (2021)
- Hu Z, "Neutrophil extracellular traps induce IL-1β production by macrophages in combination with lipopolysaccharide", Int J Mol Med, 39, pp.549~558 (2017)
- Li L, "Neutrophil extracellular traps promote aberrant macrophages activation in Behçet’s disease", Front Immunol, 11, pp.590622~ (2021)
- An Z, "Neutrophil extracellular traps induced by IL-8 aggravate atherosclerosis via activation NF-κB signaling in macrophages", Cell Cycle, 18, pp.2928~2938 (2019)
- Guimarães-Costa AB, "Neutrophil extracellular traps reprogram Il-4", GM-CSF-induced monocyte differentiation to anti-inflammatory macrophages, 2017, pp.8, 523~
- Donis-Maturano L, "Prolonged exposure to neutrophil extracellular traps can induce mitochondrial damage in macrophages and dendritic cells", Springerplus, 4, pp.161~ (2015)
- Haider P, "Neutrophil extracellular trap degradation by differently polarized macrophage subsets", Arterioscler Thromb Vasc Biol, 40, pp.2265~2278 (2020)
- Farrera C, "Macrophage clearance of neutrophil extracellular traps is a silent process", J Immunol, 191, pp.2647~2656 (2013)
- Grégoire M, "Impaired efferocytosis and neutrophil extracellular trap clearance by macrophages in ARDS", Eur Respir J, 52, pp.1702590~ (2018)
- Li H, "Neutrophil extracellular traps augmented alveolar macrophage pyroptosis via aim2 inflammasome activation in LPS-induced ALI", ARDS, 2021, pp.14, 4839~4858
- Apel F, "The cytosolic DNA sensor cGAS recognizes neutrophil extracellular traps", Sci Signal, 14 (2021)
- Lande R, "Neutrophils activate plasmacytoid dendritic cells by releasing self-DNA-peptide complexes in systemic lupus erythematosus", Sci Transl Med, 3, pp.73~ (2011)
- Garcia-Romo GS, "Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus", Sci Transl Med, 3 (2011)
- Matsushima H, "Neutrophil differentiation into a unique hybrid population exhibiting dual phenotype and functionality of neutrophils and dendritic cells", Blood, 121, pp.1677~1689 (2013)
- Barrientos L, "Neutrophil extracellular traps downregulate lipopolysaccharide-induced activation of monocyte-derived dendritic cells", J Immunol, 193, pp.5689~5698 (2014)
- Tillack K, "T lymphocyte priming by neutrophil extracellular traps links innate and adaptive immune responses", J Immunol, 188, pp.3150~3159 (2012)
- Kaltenmeier C, "Neutrophil extracellular traps promote t cell exhaustion in the tumor microenvironment", Front Immunol, 12, pp.785222~ (2021)
- "Low-dose nanotherapy-mediated site-specific inhibition of neutrophil extracellular traps for immunoregulatory treatment of asthma" (2021)[URL]
- Nie M, "Neutrophil extracellular traps induced by IL8 promote diffuse large B-cell lymphoma progression via the TLR9 signaling", Clin Cancer Res, 25, pp.1867~1879 (2019)
- Kolonics F, "Neutrophils produce proinflammatory or anti-inflammatory extracellular vesicles depending on the environmental conditions", J Leukoc Biol, 109, pp.793~806 (2021)
- Lim K, "Neutrophil trails guide influenza-specific CD8+ T cells in the airways", Science, 349 (2015)
- Gasser O, "Activated polymorphonuclear neutrophils disseminate anti-inflammatory microparticles by ectocytosis", Blood, 104, pp.2543~2548 (2004)
- Eken C, "Ectosomes released by polymorphonuclear neutrophils induce a MerTK-dependent anti-inflammatory pathway in macrophages", J Biol Chem, 285, pp.39914~39921 (2010)
- Eken C, "Ectosomes of polymorphonuclear neutrophils activate multiple signaling pathways in macrophages", Immunobiology, 218, pp.382~392 (2013)
- Rhys HI, "Neutrophil microvesicles from healthy control and rheumatoid arthritis patients prevent the inflammatory activation of macrophages", EBioMedicine, 29, pp.60~69 (2018)
- Duarte TA, "Mycobacterium tuberculosis-induced neutrophil ectosomes decrease macrophage activation", Tuberculosis(Edinb), 92, pp.218~225 (2012)
- Alvarez-Jiménez VD, "Extracellular vesicles released from mycobacterium tuberculosis-infected neutrophils promote macrophage autophagy and decrease intracellular mycobacterial survival", Front Immunol, 9, pp.272~ (2018)
- "Neutrophil-derived exosomes induce m1 macrophage polarization and prime macrophage pyroptosis via mir-30d-5p in sepsis" (2021)[URL]
- Johnson BL 3rd, "Neutrophil derived microparticles increase mortality and the counter-inflammatory response in a murine model of sepsis", Biochim Biophys Acta BBAMol Basis Dis, 1863, pp.2554~2563 (2017)
- Dalli J, "Specific lipid mediator signatures of human phagocytes : microparticles stimulate macrophage efferocytosis and pro-resolving mediators", Blood, 120, pp.e60~e72 (2012)
- Wang Y, "Exosomes released by granulocytic myeloid-derived suppressor cells attenuate DSS-induced colitis in mice", Oncotarget, 7, pp.15356~15368 (2016)
- Zhu D, "G-MDSC-derived exosomes attenuate collagen-induced arthritis by impairing Th1 and Th17 cell responses", Biochim Biophys Acta Mol Basis Dis, 1865, pp.165540~ (2019)
- Shen G, "Microvesicles released by apoptotic human neutrophils suppress proliferation and IL-2", IL-2 receptor expression of resting T helper cells, 2017, pp.47, 900~910
- Greenlee-Wacker MC, "Clearance of apoptotic neutrophils and resolution of inflammation", Immunol Rev, 273, pp.357~370 (2016)
- Marwick JA, "Neutrophils induce macrophage anti-inflammatory reprogramming by suppressing NF-κB activation", Cell Death Dis, 9, pp.665~ (2018)
- Byrne A, "Lipopolysaccharide induces rapid production of IL-10 by monocytes in the presence of apoptotic neutrophils", J Immunol, 168, pp.1968~1977 (2002)
- Thieblemont N, "Regulation of macrophage activation by proteins expressed on apoptotic neutrophils : subversion towards autoimmunity by proteinase 3", Eur J Clin Invest, 48(Suppl 2), pp.e12990~ (2018)
- Persson YAZ, "Mycobacterium tuberculosis-induced apoptotic neutrophils trigger a pro-inflammatory response in macrophages through release of heat shock protein 72, acting in synergy with the bacteria", Microbes Infect, 10, pp.233~240 (2008)
- Andersson AM, "Efferocytosis of apoptotic neutrophils enhances control of mycobacterium tuberculosis in HIV-coinfected macrophages in a myeloperoxidase-dependent manner", J Innate Immun, 12, pp.235~247 (2020)
- Stark MA, "Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17", Immunity, 22, pp.285~294 (2005)
- Clayton AR, "Dendritic cell uptake of human apoptotic and necrotic neutrophils inhibits CD40, CD80, and CD86 expression and reduces allogeneic T cell responses : relevance to systemic vasculitis", Arthritis Rheum, 48, pp.2362~2374 (2003)
- Ren Y, "Apoptotic cells protect mice against lipopolysaccharide-induced shock", J Immunol, 180, pp.4978~4985 (2008)
