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The Emerging Role of Eosinophils as Multifunctional Leukocytes in Health and Disease

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초록

Eosinophils are terminally differentiated cytotoxic effector cells that have a role in parasitic infections and allergy by releasing their granule-derived cytotoxic proteins. However, an increasing number of recent observations indicate that eosinophils are not only associated with the pathogenesis of a wide range of diseases, but also contribute to the maintenance of homeostatic responses in previously underappreciated diverse tissues, such as the gastrointestinal (GI) tract and adipose tissue. In this review, we describe biological characteristics of eosinophils, as their developmental properties, permissive proliferation and survival, degranulation activity, and migration properties enable them to distribute to both homeostatic and inflamed tissues. We describe pathologic aspects of eosinophils with a role in asthma and in various GI diseases, including eosinophilic GI disorders, inflammatory bowel disease, and radiation-induced enteropathy. Finally, we discuss the beneficial role of eosinophils, which contribute to the resolution of pathogenic conditions and to the modulation of homeostatic biologic responses.

Abstract

Eosinophils are terminally differentiated cytotoxic effector cells that have a role in parasitic infections and allergy by releasing their granule-derived cytotoxic proteins. However, an increasing number of recent observations indicate that eosinophils are not only associated with the pathogenesis of a wide range of diseases, but also contribute to the maintenance of homeostatic responses in previously underappreciated diverse tissues, such as the gastrointestinal (GI) tract and adipose tissue. In this review, we describe biological characteristics of eosinophils, as their developmental properties, permissive proliferation and survival, degranulation activity, and migration properties enable them to distribute to both homeostatic and inflamed tissues. We describe pathologic aspects of eosinophils with a role in asthma and in various GI diseases, including eosinophilic GI disorders, inflammatory bowel disease, and radiation-induced enteropathy. Finally, we discuss the beneficial role of eosinophils, which contribute to the resolution of pathogenic conditions and to the modulation of homeostatic biologic responses.

참고문헌 (83)

  1. Jung Y, "Roles and regulation of gastrointestinal eosinophils in immunity and disease", J Immunol, 193, pp.999~1005 (2014)
  2. 정윤재, "Comparative Analysis of Dibutyric cAMP and Butyric Acid on the Differentiation of Human Eosinophilic Leukemia EoL-1 Cells", Immune Network, 15(6), pp.313~318 (2015), 대한면역학회[DOI]
  3. Rothenberg ME, "The eosinophil", Annu Rev Immunol, 24, pp.147~174 (2006)
  4. Rosenberg HF, "Eosinophils : changing perspectives in health and disease", Nat Rev Immunol, 13, pp.9~22 (2013)
  5. Weller PF, "Functions of tissue-resident eosinophils", Nat Rev Immunol, 17, pp.746~760 (2017)
  6. Wen T, "The regulatory function of eosinophils", Microbiol Spectr, 4 (2016)
  7. Rothenberg ME, "Eosinophilic gastrointestinal disorders(EGID)", J Allergy Clin Immunol, 113, pp.11~28 (2004)
  8. Long H, "A player and coordinator : the versatile roles of eosinophils in the immune system", Transfus Med Hemother, 43, pp.96~108 (2016)
  9. Yu C, "Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo", J Exp Med, 195, pp.1387~1395 (2002)
  10. Hara T, "Function and signal transduction mediated by the interleukin 3 receptor system in hematopoiesis", Stem Cells, 14, pp.605~618 (1996)
  11. Mould AW, "Relationship between interleukin-5 and eotaxin in regulating blood and tissue eosinophilia in mice", J Clin Invest, 99, pp.1064~1071 (1997)
  12. Klose CS, "Innate lymphoid cells as regulators of immunity, inflammation and tissue homeostasis", Nat Immunol, 17, pp.765~774 (2016)
  13. Nussbaum JC, "Type 2 innate lymphoid cells control eosinophil homeostasis", Nature, 502, pp.245~248 (2013)
  14. Molofsky AB, "Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages", J Exp Med, 210, pp.535~549 (2013)
  15. Sugawara R, "Small intestinal eosinophils regulate Th17 cells by producing IL-1 receptor antagonist", J Exp Med, 213, pp.555~567 (2016)
  16. Egea L, "GM-CSF : a role in immune and inflammatory reactions in the intestine", Expert Rev Gastroenterol Hepatol, 4, pp.723~731 (2010)
  17. Ikutani M, "Identification of innate IL-5-producing cells and their role in lung eosinophil regulation and antitumor immunity", J Immunol, 188, pp.703~713 (2012)
  18. Cherry WB, "A novel IL-1 family cytokine, IL-33, potently activates human eosinophils", J Allergy Clin Immunol, 121, pp.1484~1490 (2008)
  19. Wong CK, "Thymic stromal lymphopoietin induces chemotactic and prosurvival effects in eosinophils : implications in allergic inflammation", Am J Respir Cell Mol Biol, 43, pp.305~315 (2010)
  20. Munitz A, "Inhibitory receptors on eosinophils : a direct hit to a possible Achilles heel", J Allergy Clin Immunol, 119, pp.1382~1387 (2007)
  21. Munitz A, "The inhibitory receptor IRp60(CD300a)suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils", Blood, 107, pp.1996~2003 (2006)
  22. Ben Baruch-Morgenstern N, "Paired immunoglobulin-like receptor A is an intrinsic, self-limiting suppressor of IL-5-induced eosinophil development", Nat Immunol, 15, pp.36~44 (2014)
  23. Daugherty BL, "Cloning, expression, and characterization of the human eosinophil eotaxin receptor", J Exp Med, 183, pp.2349~2354 (1996)
  24. Ponath PD, "Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils", J Exp Med, 183, pp.2437~2448 (1996)
  25. Barthel SR, "Roles of integrin activation in eosinophil function and the eosinophilic inflammation of asthma", J Leukoc Biol, 83, pp.1~12 (2008)
  26. Mishra A, "Fundamental signals that regulate eosinophil homing to the gastrointestinal tract", J Clin Invest, 103, pp.1719~1727 (1999)
  27. Brandt EB, "The alpha4bbeta7-integrin is dynamically expressed on murine eosinophils and involved in eosinophil trafficking to the intestine", Clin Exp Allergy, 36, pp.543~553 (2006)
  28. Shah K, "The emerging roles of eosinophils in mucosal homeostasis", Mucosal Immunol. (2020)
  29. Wu D, "Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis", Science, 332, pp.243~247 (2011)
  30. Mesnil C, "Lung-resident eosinophils represent a distinct regulatory eosinophil subset", J Clin Invest, 126, pp.3279~3295 (2016)
  31. Throsby M, "CD11c+ eosinophils in the murine thymus : developmental regulation and recruitment upon MHC class I-restricted thymocyte deletion", J Immunol, 165, pp.1965~1975 (2000)
  32. Carlens J, "Common gamma-chain-dependent signals confer selective survival of eosinophils in the murine small intestine", J Immunol, 183, pp.5600~5607 (2009)
  33. Spencer LA, "Eosinophil secretion of granule-derived cytokines", Front Immunol, 5, pp.496~ (2014)
  34. Scepek S, "Compound exocytosis and cumulative degranulation by eosinophils and their role in parasite killing", Parasitol Today, 10, pp.276~278 (1994)
  35. Ueki S, "Eosinophil extracellular DNA trap cell death mediates lytic release of free secretion-competent eosinophil granules in humans", Blood, 121, pp.2074~2083 (2013)
  36. Ueki S, "Eosinophil ETosis and DNA traps : a new look at eosinophilic inflammation", Curr Allergy Asthma Rep, 16, pp.54~ (2016)
  37. Neves JS, "Eosinophil granules function extracellularly as receptor-mediated secretory organelles", Proc Natl Acad Sci U S A, 105, pp.18478~18483 (2008)
  38. Murdoch JR, "Chronic inflammation and asthma", Mutat Res, 690, pp.24~39 (2010)
  39. Wills-Karp M, "Biomedicine. Eosinophils in asthma : remodeling a tangled tale", Science, 305, pp.1726~1729 (2004)
  40. Kanda A, "Multiple biological aspects of eosinophils in host defense, eosinophil-associated diseases, immunoregulation, and homeostasis : Is their role beneficial, detrimental, regulator, or bystander", Biol Pharm Bull, 43, pp.20~30 (2020)
  41. Muniz VS, "Eosinophils release extracellular DNA traps in response to Aspergillus fumigatus", J Allergy Clin Immunol, 141, pp.571~585 (2018)
  42. Drake MG, "Eosinophil and airway nerve interactions in asthma", J Leukoc Biol, 104, pp.61~67 (2018)
  43. Fryer AD, "Neuronal eotaxin and the effects of CCR3 antagonist on airway hyperreactivity and M2 receptor dysfunction", J Clin Invest, 116, pp.228~236 (2006)
  44. Jacoby DB, "Human eosinophil major basic protein is an endogenous allosteric antagonist at the inhibitory muscarinic M2 receptor", J Clin Invest, 91, pp.1314~1318 (1993)
  45. Gu Q, "Mechanisms of eosinophil major basic protein-induced hyperexcitability of vagal pulmonary chemosensitive neurons", Am J Physiol Lung Cell Mol Physiol, 296, pp.L453~ (2009)
  46. Noel RJ, "Eosinophilic esophagitis", N Engl J Med, 351, pp.940~941 (2004)
  47. Blanchard C, "Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis", J Clin Invest, 116, pp.536~547 (2006)
  48. Wen T, "Molecular diagnosis of eosinophilic esophagitis by gene expression profiling", Gastroenterology, 145, pp.1289~1299 (2013)
  49. Collins MH, "Eosinophilic gastrointestinal disorders pathology", Front Med(Lausanne), 4, pp.261~ (2018)
  50. Click B, "Peripheral eosinophilia in patients with inflammatory bowel disease defines an aggressive disease phenotype", Am J Gastroenterol, 112, pp.1849~1858 (2017)
  51. Smyth CM, "Activated eosinophils in association with enteric nerves in inflammatory bowel disease", PLoS One, 8, pp.e64216~ (2013)
  52. Filippone RT, "Eosinophils in inflammatory bowel disease", Inflamm Bowel Dis, 25, pp.1140~1151 (2019)
  53. Levy AM, "Increased eosinophil granule proteins in gut lavage fluid from patients with inflammatory bowel disease", Mayo Clin Proc, 72, pp.117~123 (1997)
  54. Masterson JC, "Eosinophil-mediated signalling attenuates inflammatory responses in experimental colitis", Gut, 64, pp.1236~1247 (2015)
  55. Hauer-Jensen M, "Radiation enteropathy--pathogenesis, treatment and prevention", Nat Rev Gastroenterol Hepatol, 11, pp.470~479 (2014)
  56. Stacey R, "Radiation-induced small bowel disease : latest developments and clinical guidance", Ther Adv Chronic Dis, 5, pp.15~29 (2014)
  57. Takemura N, "Eosinophil depletion suppresses radiation-induced small intestinal fibrosis", Sci Transl Med, 10, pp.eaan0333~ (2018)
  58. Kvarnhammar AM, "Pattern-recognition receptors in human eosinophils", Immunology, 136, pp.11~20 (2012)
  59. Phipps S, "Eosinophils contribute to innate antiviral immunity and promote clearance of respiratory syncytial virus", Blood, 110, pp.1578~1586 (2007)
  60. Rosenberg HF, "Eosinophils, eosinophil ribonucleases, and their role in host defense against respiratory virus pathogens", J Leukoc Biol, 70, pp.691~698 (2001)
  61. Soukup JM, "Role of monocytes and eosinophils in human respiratory syncytial virus infection in vitro", Clin Immunol, 107, pp.178~185 (2003)
  62. Mathur SK, "Interaction between allergy and innate immunity : model for eosinophil regulation of epithelial cell interferon expression", Ann Allergy Asthma Immunol, 111, pp.25~31 (2013)
  63. Torrent M, "Eosinophil cationic protein high-affinity binding to bacteria-wall lipopolysaccharides and peptidoglycans", Biochemistry, 47, pp.3544~3555 (2008)
  64. Yousefi S, "Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense", Nat Med, 14, pp.949~953 (2008)
  65. Williams TJ, "The eosinophil enigma", J Clin Invest, 113, pp.507~509 (2004)
  66. Goh YP, "Eosinophils secrete IL-4 to facilitate liver regeneration", Proc Natl Acad Sci U S A, 110, pp.9914~9919 (2013)
  67. Heredia JE, "Type 2 innate signals stimulate fibro", adipogenic progenitors to facilitate muscle regeneration, 2013, pp.153, 376~388
  68. Leitch VD, "IL-5-overexpressing mice exhibit eosinophilia and altered wound healing through mechanisms involving prolonged inflammation", Immunol Cell Biol, 87, pp.131~140 (2009)
  69. Sakkal S, "Eosinophils in cancer : favourable or unfavourable", Curr Med Chem, 23, pp.650~666 (2016)
  70. Reichman H, "Emerging roles for eosinophils in the tumor microenvironment", Trends Cancer, 2, pp.664~675 (2016)
  71. Reichman H, "Activated eosinophils exert antitumorigenic activities in colorectal cancer", Cancer Immunol Res, 7, pp.388~400 (2019)
  72. Hollande C, "Inhibition of the dipeptidyl peptidase DPP4(CD26)reveals IL-33-dependent eosinophil-mediated control of tumor growth", Nat Immunol, 20, pp.257~264 (2019)
  73. von Wasielewski R, "Tissue eosinophilia correlates strongly with poor prognosis in nodular sclerosing Hodgkin's disease, allowing for known prognostic factors", Blood, 95, pp.1207~1213 (2000)
  74. Ruffell B, "Differential macrophage programming in the tumor microenvironment", Trends Immunol, 33, pp.119~126 (2012)
  75. Khodadadi L, "The maintenance of memory plasma cells", Front Immunol, 10, pp.721~ (2019)
  76. Chu VT, "Eosinophils are required for the maintenance of plasma cells in the bone marrow", Nat Immunol, 12, pp.151~159 (2011)
  77. Cerutti A, "The regulation of IgA class switching", Nat Rev Immunol, 8, pp.421~434 (2008)
  78. Chu VT, "Eosinophils promote generation and maintenance of immunoglobulin-A-expressing plasma cells and contribute to gut immune homeostasis", Immunity, 40, pp.582~593 (2014)
  79. Jung Y, "IL-1β in eosinophil-mediated small intestinal homeostasis and IgA production", Mucosal Immunol, 8, pp.930~942 (2015)
  80. Castoldi A, "The macrophage switch in obesity development", Front Immunol, 6, pp.637~ (2016)
  81. Yoon J, "Eosinophil activation by Toll-like receptor 4 ligands regulates macrophage polarization", Front Cell Dev Biol, 7, pp.329~ (2019)
  82. Lee EH, "Eosinophils support adipocyte maturation and promote glucose tolerance in obesity", Sci Rep, 8, pp.9894~ (2018)
  83. Qiu Y, "Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat", Cell, 157, pp.1292~1308 (2014)

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