Mast Cells in Allergic Asthma and Beyond
2
조회
0
다운로드
2
인용
0
참고문헌
키워드
초록
Mast cells have been regarded for a long time as effector cells in IgE mediated type I reactions and in host defence against parasites. However, they are resident in all environmental exposed tissues and express a wide variety of receptors, suggesting that these cells can also function as sentinels in innate immune responses. Indeed, studies have demonstrated an important role of mast cells during the induction of life-saving antibacterial responses. Furthermore, recent findings have shown that mast cells promote and modulate the development of adaptive immune responses, making them an important hinge of innate and acquired immunity. In addition, mast cells and several mast cell-produced mediators have been shown to be important during the development of allergic airway diseases. In the present review, we will summarize findings on the role of mast cells during the development of adaptive immune responses and highlight their function, especially during the development of allergic asthma.
Abstract
Mast cells have been regarded for a long time as effector cells in IgE mediated type I reactions and in host defence against parasites. However, they are resident in all environmental exposed tissues and express a wide variety of receptors, suggesting that these cells can also function as sentinels in innate immune responses. Indeed, studies have demonstrated an important role of mast cells during the induction of life-saving antibacterial responses. Furthermore, recent findings have shown that mast cells promote and modulate the development of adaptive immune responses, making them an important hinge of innate and acquired immunity. In addition, mast cells and several mast cell-produced mediators have been shown to be important during the development of allergic airway diseases. In the present review, we will summarize findings on the role of mast cells during the development of adaptive immune responses and highlight their function, especially during the development of allergic asthma.
참고문헌 (145)
- Kawakami T, "Regulation of mast-cell and basophil function and survival by IgE", Nat Rev Immunol, 2, pp.773~786 (2002)
- Metcalfe DD, "Mast cells", Physiol Rev, 77, pp.1033~1079 (1997)
- Irani AA, "Two types of human mast cells that have distinct neutral protease compositions", Proc Natl Acad Sci U S A, 83, pp.4464~4468 (1986)
- Irani AM, "Deficiency of the tryptase-positive, chymase-negative mast cell type in gastrointestinal mucosa of patients with defective T lymphocyte function", J Immunol, 138, pp.4381~4386 (1987)
- Goldstein SM, "Detection and partial characterization of a human mast cell carboxypeptidase", J Immunol, 139, pp.2724~2729 (1987)
- Enerbäck L, "Intraepithelial migration of nasal mucosal mast cells in hay fever", Int Arch Allergy Appl Immunol, 80, pp.44~51 (1986)
- Galli SJ, "Mast cells as “tunable” effector and immunoregulatory cells: recent advances", Annu Rev Immunol, 23, pp.749~786 (2005)
- Murakami M, "Prostaglandin endoperoxide synthase-1 and -2 couple to different transmembrane stimuli to generate prostaglandin D2 in mouse bone marrow-derived mast cells", J Biol Chem, 269, pp.22269~22275 (1994)
- Urade Y, "Mast cells contain spleen-type prostaglandin D synthetase", J Biol Chem, 265, pp.371~375 (1990)
- Murphy RC, "Biosynthesis and metabolism of leukotrienes", Biochem J, 405, pp.379~395 (2007)
- Gordon JR, "Mast cells as a source of both preformed and immunologically inducible TNF-alpha", cachectin, 1990, pp.346, 274~276
- Young JD, "Identification, purification, and characterization of a mast cell-associated cytolytic factor related to tumor necrosis factor", Proc Natl Acad Sci U S A, 84, pp.9175~9179 (1987)
- Metzger H, "The receptor with high affinity for IgE", Immunol Rev, 125, pp.37~48 (1992)
- Turner H, "Signalling through the high-affinity IgE receptor Fc epsilonRI", Nature, 402, pp.B24~30 (1999)
- Mayr SI, "Role of immunoglobulin E and mast cells in murine models of asthma", Braz J Med Biol Res, 36, pp.821~827 (2003)
- Schweitzer-Stenner R, "Death of a dogma or enforcing the artificial: monomeric IgE binding may initiate mast cell response by inducing its receptor aggregation", J Immunol, 174, pp.4461~4464 (2005)
- Kawakami T, "Regulation of mast-cell and basophil function and survival by IgE", Nat Rev Immunol, 2, pp.773~786 (2002)
- Kalesnikoff J, "Monomeric IgE stimulates signaling pathways in mast cells that lead to cytokine production and cell survival", Immunity, 14, pp.801~811 (2001)
- Lee DM, "Mast cells: a cellular link between autoantibodies and inflammatory arthritis", Science, 297, pp.1689~1692 (2002)
- Robbie-Ryan M, "Cutting edge: both activating and inhibitory Fc receptors expressed on mast cells regulate experimental allergic encephalomyelitis disease severity", J Immunol, 170, pp.1630~1634 (2003)
- Vaz NM, "Behaviour of mouse mast cells during anaphylaxis in vitro", Prog Allergy, 13, pp.111~173 (1969)
- Daëron M, "Regulation of high-affinity IgE receptor-mediated mast cell activation by murine low-affinity IgG receptors", J Clin Invest, 95, pp.577~585 (1995)
- Daëron M, "The same tyrosine-based inhibition motif, in the intracytoplasmic domain of Fc gamma RIIB, regulates negatively BCR-, TCR-, and FcR-dependent cell activation", Immunity, 3, pp.635~646 (1995)
- Takai T, "Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice", Nature, 379, pp.346~349 (1996)
- Ujike A, "Modulation of immunoglobulin (Ig)E-mediated systemic anaphylaxis by low-affinity Fc receptors for IgG", J Exp Med, 189, pp.1573~1579 (1999)
- Metz M, "Mast cell functions in the innate skin immune system", Immunobiology, 213, pp.251~260 (2008)
- Leal-Berumen I, "IL-6 production by rat peritoneal mast cells is not necessarily preceded by histamine release and can be induced by bacterial lipopolysaccharide", J Immunol, 152, pp.5468~5476 (1994)
- Dvorak AM, "Piecemeal degranulation of basophils and mast cells is effected by vesicular transport of stored secretory granule contents", Chem Immunol Allergy, 85, pp.135~184 (2005)
- Kitamura Y, "Decrease of mast cells in W", Wv mice and their increase by bone marrow transplantation, 1978, pp.52, 447~452
- Kitamura Y, "Decreased production of mast cells in S1", S1d anemic mice, 1979, pp.53, 492~497
- Geissler EN, "The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene", Cell, 55, pp.185~192 (1988)
- Galli SJ, "The kit ligand, stem cell factor", Adv Immunol, 55, pp.1~96 (1994)
- Nocka K, "Molecular bases of dominant negative and loss of function mutations at the murine c-kit", white spotting locus: W37, Wv, W41 and W, 1990, pp.9, 1805~1813
- Duttlinger R, "W-sash affects positive and negative elements controlling c-kit expression: ectopic c-kit expression at sites of kit-ligand expression affects melanogenesis", Development, 118, pp.705~717 (1993)
- Nigrovic PA, "Genetic inversion in mast cell-deficient (W(sh)) mice interrupts corin and manifests as hematopoietic and cardiac aberrancy", Am J Pathol, 173, pp.1693~1701 (2008)
- Lyon MF, "A new allele sash (Wsh) at the W-locus and a spontaneous recessive lethal in mice", Genet Res, 39, pp.315~322 (1982)
- Tono T, "c-kit Gene was not transcribed in cultured mast cells of mast cell-deficient Wsh", Wsh mice that have a normal number of erythrocytes and a normal c-kit coding region, 1992, pp.80, 1448~1453
- Tsai M, "Mast cells derived from embryonic stem cells: a model system for studying the effects of genetic manipulations on mast cell development, phenotype, and function in vitro and in vivo", Int J Hematol, 75, pp.345~349 (2002)
- Grimbaldeston MA, "Mast cell-deficient W-sash c-kit mutant Kit W-sh", W-sh mice as a model for investigating mast cell biology in vivo, 2005, pp.167, 835~848
- Wolters PJ, "Tissue-selective mast cell reconstitution and differential lung gene expression in mast cell-deficient Kit(W-sh)", Kit (W-sh) sash mice, 2005, pp.35, 82~88
- Scholten J, "Mast cell-specific Cre", loxP-mediated recombination in vivo, 2008, pp.17, 307~315
- Lambrecht BN, "Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation", J Clin Invest, 106, pp.551~559 (2000)
- Vermaelen KY, "Specific migratory dendritic cells rapidly transport antigen from the airways to the thoracic lymph nodes", J Exp Med, 193, pp.51~60 (2001)
- van Rijt LS, "Essential role of dendritic cell CD80", CD86 costimulation in the induction, but not reactivation, of Th2 effector responses in a mouse model of asthma, 2004, pp.114, 166~173
- Kaiko GE, "Immunological decision-making: how does the immune system decide to mount a helper T-cell response?", Immunology, 123, pp.326~338 (2008)
- Jawdat DM, "IgEmediated mast cell activation induces Langerhans cell migration in vivo", J Immunol, 173, pp.5275~5282 (2004)
- Jawdat DM, "Mast cells have a pivotal role in TNF-independent lymph node hypertrophy and the mobilization of Langerhans cells in response to bacterial peptidoglycan", J Immunol, 177, pp.1755~1762 (2006)
- Heib V, "Mast cells are crucial for early inflammation, migration of Langerhans cells, and CTL responses following topical application of TLR7 ligand in mice", Blood, 110, pp.946~953 (2007)
- Bryce PJ, "Immune sensitization in the skin is enhanced by antigen-independent effects of IgE", Immunity, 20, pp.381~392 (2004)
- Suto H, "Mast cell-associated TNF promotes dendritic cell migration", J Immunol, 176, pp.4102~4112 (2006)
- Reuter S, "Mast cells induce migration of dendritic cells in a murine model of acute allergic airway disease", Int Arch Allergy Immunol, 151, pp.214~222 (2010)
- McIlroy A, "Histamine and prostaglandin E up-regulate the production of Th2-attracting chemokines (CCL17 and CCL22) and down-regulate IFN-gamma-induced CXCL10 production by immature human dendritic cells", Immunology, 117, pp.507~516 (2006)
- Theiner G, "The mast cell mediator PGD2 suppresses IL-12 release by dendritic cells leading to Th2 polarized immune responses in vivo", Immunobiology, 211, pp.463~472 (2006)
- Wang HW, "Mast cell activation and migration to lymph nodes during induction of an immune response in mice", J Clin Invest, 102, pp.1617~1626 (1998)
- McLachlan JB, "Mast cell-derived tumor necrosis factor induces hypertrophy of draining lymph nodes during infection", Nat Immunol, 4, pp.1199~1205 (2003)
- Nakae S, "Mast cells enhance T cell activation: Importance of mast cellderived TNF", Proc Natl Acad Sci U S A, 102, pp.6467~6472 (2005)
- Nakae S, "Mast cells enhance T cell activation: importance of mast cell costimulatory molecules and secreted TNF", J Immunol, 176, pp.2238~2248 (2006)
- Stelekati E, "Mast cell-mediated antigen presentation regulates CD8+ T cell effector functions", Immunity, 31, pp.665~676 (2009)
- Malaviya R, "Mast cells process bacterial Ags through a phagocytic route for class I MHC presentation to T cells", J Immunol, 156, pp.1490~1496 (1996)
- Gauchat JF, "Induction of human IgE synthesis in B cells by mast cells and basophils", Nature, 365, pp.340~343 (1993)
- Poncet P, "MHC class II-dependent activation of CD4+ T cell hybridomas by human mast cells through superantigen presentation", J Leukoc Biol, 66, pp.105~112 (1999)
- Grabbe J, "Induction of MHC class II antigen expression on human HMC-1 mast cells", J Dermatol Sci, 16, pp.67~73 (1997)
- Kambayashi T, "Inducible MHC class II expression by mast cells supports effector and regulatory T cell activation", J Immunol, 182, pp.4686~4695 (2009)
- Skokos D, "Mast cell-derived exosomes induce phenotypic and functional maturation of dendritic cells and elicit specific immune responses in vivo", J Immunol, 170, pp.3037~3045 (2003)
- Taussig LM, "Tucson Children’s Respiratory Study: 1980 to present", J Allergy Clin Immunol, 111, pp.661~675 (2003)
- De Marco R, "Incidence and remission of asthma: a retrospective study on the natural history of asthma in Italy", J Allergy Clin Immunol, 110, pp.228~235 (2002)
- Bradding P, "Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines", Am J Respir Cell Mol Biol, 10, pp.471~480 (1994)
- Carroll NG, "Increased mast cells and neutrophils in submucosal mucous glands and mucus plugging in patients with asthma", Thorax, 57, pp.677~682 (2002)
- Brightling CE, "Mast-cell infiltration of airway smooth muscle in asthma", N Engl J Med, 346, pp.1699~1705 (2002)
- Yang W, "Human lung mast cells adhere to human airway smooth muscle, in part, via tumor suppressor in lung cancer-1", J Immunol, 176, pp.1238~1243 (2006)
- Woodman L, "Mast cells promote airway smooth muscle cell differentiation via autocrine up-regulation of TGF-beta 1", J Immunol, 181, pp.5001~5007 (2008)
- Hollins F, "Human airway smooth muscle promotes human lung mast cell survival, proliferation, and constitutive activation: cooperative roles for CADM1, stem cell factor, and IL-6", J Immunol, 181, pp.2772~2780 (2008)
- Kaur D, "Airway smooth muscle proliferation and survival is not modulated by mast cells", Clin Exp Allergy, 40, pp.279~288 (2010)
- Murray JJ, "Prostaglandin D2 is released during acute allergic bronchospasm in man", Trans Assoc Am Physicians, 98, pp.275~280 (1985)
- Liu MC, "Immediate and late inflammatory responses to ragweed antigen challenge of the peripheral airways in allergic asthmatics. Cellular, mediator, and permeability changes", Am Rev Respir Dis, 144, pp.51~58 (1991)
- Casale TB, "Direct evidence of a role for mast cells in the pathogenesis of antigen-induced bronchoconstriction", J Clin Invest, 80, pp.1507~1511 (1987)
- Roquet A, "Combined antagonism of leukotrienes and histamine produces predominant inhibition of allergen-induced early and late phase airway obstruction in asthmatics", Am J Respir Crit Care Med, 155, pp.1856~1863 (1997)
- Hamilton A, "Pranlukast, a cysteinyl leukotriene receptor antagonist, attenuates allergen-induced early- and late-phase bronchoconstriction and airway hyperresponsiveness in asthmatic subjects", J Allergy Clin Immunol, 102, pp.177~183 (1998)
- Fahy JV, "The effect of an anti-IgE monoclonal antibody on the earlyand late-phase responses to allergen inhalation in asthmatic subjects", Am J Respir Crit Care Med, 155, pp.1828~1834 (1997)
- Taube C, "Insights into the pathogenesis of asthma utilizing murine models", Int Arch Allergy Immunol, 135, pp.173~186 (2004)
- Boyce JA, "No audible wheezing: nuggets and conundrums from mouse asthma models", J Exp Med, 201, pp.1869~1873 (2005)
- Takeda K, "Development of eosinophilic airway inflammation and airway hyperresponsiveness in mast cell-deficient mice", J Exp Med, 186, pp.449~454 (1997)
- Hamelmann E, "Development of eosinophilic airway inflammation and airway hyperresponsiveness requires interleukin-5 but not immunoglobulin E or B lymphocytes", Am J Respir Cell Mol Biol, 21, pp.480~489 (1999)
- Mehlhop PD, "Allergen-induced bronchial hyperreactivity and eosinophilic inflammation occur in the absence of IgE in a mouse model of asthma", Proc Natl Acad Sci U S A, 94, pp.1344~1349 (1997)
- MacLean JA, "Antigen-induced airway hyperresponsiveness, pulmonary eosinophilia, and chemokine expression in B cell-deficient mice", Am J Respir Cell Mol Biol, 20, pp.379~387 (1999)
- Ogawa K, "Primary role of CD4+ T cells and supplemental role of mast cells in allergic pulmonary eosinophilia", Int Arch Allergy Immunol, 120, pp.15~18 (1999)
- Kung TT, "Mast cells modulate allergic pulmonary eosinophilia in mice", Am J Respir Cell Mol Biol, 12, pp.404~409 (1995)
- Kobayashi T, "An essential role of mast cells in the development of airway hyperresponsiveness in a murine asthma model", J Immunol, 164, pp.3855~3861 (2000)
- Masuda T, "Mast cells play a partial role in allergeninduced subepithelial fibrosis in a murine model of allergic asthma", Clin Exp Allergy, 33, pp.705~713 (2003)
- Eisenbarth SC, "Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants", Nature, 453, pp.1122~1126 (2008)
- Brewer JM, "Aluminium hydroxide adjuvant initiates strong antigen-specific Th2 responses in the absence of IL-4- or IL-13- mediated signaling", J Immunol, 163, pp.6448~6454 (1999)
- McKee AS, "Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity", J Immunol, 183, pp.4403~4414 (2009)
- Williams CM, "Mast cells can amplify airway reactivity and features of chronic inflammation in an asthma model in mice", J Exp Med, 192, pp.455~462 (2000)
- Yu M, "Mast cells can promote the development of multiple features of chronic asthma in mice", J Clin Invest, 116, pp.1633~1641 (2006)
- Taube C, "Mast cells, Fc epsilon RI, and IL-13 are required for development of airway hyperresponsiveness after aerosolized allergen exposure in the absence of adjuvant", J Immunol, 172, pp.6398~6406 (2004)
- Nakae S, "Mast cell-derived TNF contributes to airway hyperreactivity, inflammation, and Th2 cytokine production in an asthma model in mice", J Allergy Clin Immunol, 120, pp.48~55 (2007)
- Reuter S, "Mast cell-derived tumour necrosis factor is essential for allergic airway disease", Eur Respir J, 31, pp.773~782 (2008)
- Bradding P, "Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines", Am J Respir Cell Mol Biol, 10, pp.471~480 (1994)
- Thomas PS, "Tumor necrosis factor-alpha increases airway responsiveness and sputum neutrophilia in normal human subjects", Am J Respir Crit Care Med, 152, pp.76~80 (1995)
- Thomas PS, "Effects of inhaled tumour necrosis factor alpha in subjects with mild asthma", Thorax, 57, pp.774~778 (2002)
- Busse PJ, "Chronic exposure to TNF-alpha increases airway mucus gene expression in vivo", J Allergy Clin Immunol, 116, pp.1256~1263 (2005)
- Choi IW, "TNFalpha induces the late-phase airway hyperresponsiveness and airway inflammation through cytosolic phospholipase A(2) activation", J Allergy Clin Immunol, 116, pp.537~543 (2005)
- Nakae S, "TNF can contribute to multiple features of ovalbumin-induced allergic inflammation of the airways in mice", J Allergy Clin Immunol, 119, pp.680~686 (2007)
- Jutel M, "Histamine in allergic inflammation and immune modulation", Int Arch Allergy Immunol, 137, pp.82~92 (2005)
- Mazzoni A, "Histamine regulates cytokine production in maturing dendritic cells, resulting in altered T cell polarization", J Clin Invest, 108, pp.1865~1873 (2001)
- Jutel M, "Histamine regulates T-cell and antibody responses by differential expression of H1 and H2 receptors", Nature, 413, pp.420~425 (2001)
- Forward NA, "Mast cells down-regulate CD4+CD25+ T regulatory cell suppressor function via histamine H1 receptor interaction", J Immunol, 183, pp.3014~3022 (2009)
- Bryce PJ, "The H1 histamine receptor regulates allergic lung responses", J Clin Invest, 116, pp.1624~1632 (2006)
- Dunford PJ, "The histamine H4 receptor mediates allergic airway inflammation by regulating the activation of CD4+ T cells", J Immunol, 176, pp.7062~7070 (2006)
- Cowden JM, "Histamine H4 receptor antagonism diminishes existing airway inflammation and dysfunction via modulation of Th2 cytokines", Respir Res, 11, pp.86~ (2010)
- Fujitani Y, "Pronounced eosinophilic lung inflammation and Th2 cytokine release in human lipocalin-type prostaglandin D synthase transgenic mice", J Immunol, 168, pp.443~449 (2002)
- Honda K, "Prostaglandin D2 reinforces Th2 type inflammatory responses of airways to low-dose antigen through bronchial expression of macrophage-derived chemokine", J Exp Med, 198, pp.533~543 (2003)
- Oguma T, "Cyclooxygenase-2 expression during allergic inflammation in guinea-pig lungs", Am J Respir Crit Care Med, 165, pp.382~386 (2002)
- Matsuoka T, "Prostaglandin D2 as a mediator of allergic asthma", Science, 287, pp.2013~2017 (2000)
- Spik I, "Activation of the prostaglandin D2 receptor DP2", CRTH2 increases allergic inflammation in mouse, 2005, pp.174, 3703~3708
- Uller L, "Antagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation", Respir Res, 8, pp.16~ (2007)
- Chevalier E, "Cutting edge: chemoattractant receptor-homologous molecule expressed on Th2 cells plays a restricting role on IL-5 production and eosinophil recruitment", J Immunol, 175, pp.2056~2060 (2005)
- Xue L, "Prostaglandin D2 causes preferential induction of proinflammatory Th2 cytokine production through an action on chemoattractant receptor-like molecule expressed on Th2 cells", J Immunol, 175, pp.6531~6536 (2005)
- Henderson WR Jr, "The importance of leukotrienes in airway inflammation in a mouse model of asthma", J Exp Med, 184, pp.1483~1494 (1996)
- Irvin CG, "5-Lipoxygenase products are necessary for ovalbumin-induced airway responsiveness in mice", Am J Physiol, 272, pp.L1053~1058 (1997)
- Samuelsson B, "Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation", Science, 220, pp.568~575 (1983)
- Köller M, "Cilastatin (MK 0791) is a potent and specific inhibitor of the renal leukotriene D4-dipeptidase", Biochem Biophys Res Commun, 131, pp.974~979 (1985)
- Lam BK, "Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4", Proc Natl Acad Sci U S A, 91, pp.7663~7667 (1994)
- Orning L, "Inhibition of leukotriene C and leukotriene D biosynthesis", J Biol Chem, 255, pp.8023~8026 (1980)
- Miyahara N, "Leukotriene B4 receptor-1 is essential for allergenmediated recruitment of CD8+ T cells and airway hyperresponsiveness", J Immunol, 174, pp.4979~4984 (2005)
- Taube C, "The leukotriene B4 receptor (BLT1) is required for effector CD8+ T cell-mediated, mast cell-dependent airway hyperresponsiveness", J Immunol, 176, pp.3157~3164 (2006)
- Terawaki K, "Absence of leukotriene B4 receptor 1 confers resistance to airway hyperresponsiveness and Th2-type immune responses", J Immunol, 175, pp.4217~4225 (2005)
- Robbiani DF, "The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes", Cell, 103, pp.757~768 (2000)
- Uzonyi B, "Cysteinyl leukotriene 2 receptor and proteaseactivated receptor 1 activate strongly correlated early genes in human endothelial cells", Proc Natl Acad Sci U S A, 103, pp.6326~6331 (2006)
- Beller TC, "Targeted gene disruption reveals the role of the cysteinyl leukotriene 2 receptor in increased vascular permeability and in bleomycin-induced pulmonary fibrosis in mice", J Biol Chem, 279, pp.46129~46134 (2004)
- Gauvreau GM, "Inhaled leukotriene E(4), but not leukotriene D(4), increased airway inflammatory cells in subjects with atopic asthma", Am J Respir Crit Care Med, 164, pp.1495~1500 (2001)
- Ying S, "Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity", J Immunol, 174, pp.8183~8190 (2005)
- Al-Shami A, "A role for TSLP in the development of inflammation in an asthma model", J Exp Med, 202, pp.829~839 (2005)
- Li YL, "Thymic stromal lymphopoietin promotes lung inflammation through activation of dendritic cells", J Asthma, 47, pp.117~123 (2010)
- Allakhverdi Z, "Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells", J Exp Med, 20, pp.253~258 (2007)
- Okayama Y, "FcepsilonRI-mediated thymic stromal lymphopoietin production by interleukin-4-primed human mast cells", Eur Respir J, 34, pp.425~435 (2009)
- Miyata M, "Thymic stromal lymphopoietin is a critical mediator of IL-13-driven allergic inflammation", Eur J Immunol, 39, pp.3078~3083 (2009)
- Hammad H, "Recent progress in the biology of airway dendritic cells and implications for understanding the regulation of asthmatic inflammation", J Allergy Clin Immunol, 118, pp.331~336 (2006)
- Gosset P, "Prostaglandin D2 affects the differentiation and functions of human dendritic cells: impact on the T cell response", Eur J Immunol, 35, pp.1491~1500 (2005)
- Kitawaki T, "IgE-activated mast cells in combination with pro-inflammatory factors induce Th2-promoting dendritic cells", Int Immunol, 18, pp.1789~1799 (2006)
- Eisenbarth SC, "Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen", J Exp Med, 196, pp.1645~1651 (2002)
- Nigo YI, "Regulation of allergic airway inflammation through Toll-like receptor 4-mediated modification of mast cell function", Proc Natl Acad Sci U S A, 103, pp.2286~2291 (2006)
- Machado DC, "Potential allergens stimulate the release of mediators of the allergic response from cells of mast cell lineage in the absence of sensitization with antigen-specific IgE", Eur J Immunol, 26, pp.2972~2980 (1996)
- Yu CK, "Activation of mast cells is essential for development of house dust mite Dermatophagoides farinae-induced allergic airway inflammation in mice", J Immunol, 171, pp.3808~3815 (2003)
- Cates EC, "Intranasal exposure of mice to house dust mite elicits allergic airway inflammation via a GM-CSF-mediated mechanism", J Immunol, 173, pp.6384~6392 (2004)
