Low HDL cholesterol is associated with increased atherogenic lipoproteins and insulin resistance in women classified with metabolic syndrome
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Both metabolic syndrome (MetS) and elevated LDL cholesterol (LDL-C) increase the risk for cardiovascular disease (CVD). We hypothesized that low HDL cholesterol (HDL-C) would further increase CVD risk in women having both conditions. To assess this, we recruited 89 women with MetS (25-72 y) and LDL-C ≥ 2.6 mmol/L. To determine whether plasma HDL-C concentrations were associated with dietary components,circulating atherogenic particles, and other risk factors for CVD, we divided the subjects into two groups: high HDL-C (H-HDL) (≥ 1.3 mmol/L,n = 32) and low HDL-C (L-HDL) (< 1.3 mmol/L, n = 57). Plasma lipids, insulin, adiponectin, apolipoproteins, oxidized LDL, Lipoprotein(a), and lipoprotein size and subfractions were measured, and 3-d dietary records were used to assess macronutrient intake. Women with L-HDL had higher sugar intake and glycemic load (P < 0.05), higher plasma insulin (P < 0.01), lower adiponectin (P < 0.05), and higher numbers of atherogenic lipoproteins such as large VLDL (P < 0.01) and small LDL (P < 0.001) than the H-HDL group. Women with L-HDL also had larger VLDL and both smaller LDL and HDL particle diameters (P < 0.001). HDL-C was positively correlated with LDL size (r = 0.691, P < 0.0001) and HDL size (r = 0.606,P < 0.001), and inversely correlated with VLDL size (r = -0.327, P < 0.01). We concluded that L-HDL could be used as a marker for increased numbers of circulating atherogenic lipoproteins as well as increased insulin resistance in women who are already at risk for CVD.
Abstract
Both metabolic syndrome (MetS) and elevated LDL cholesterol (LDL-C) increase the risk for cardiovascular disease (CVD). We hypothesized that low HDL cholesterol (HDL-C) would further increase CVD risk in women having both conditions. To assess this, we recruited 89 women with MetS (25-72 y) and LDL-C ≥ 2.6 mmol/L. To determine whether plasma HDL-C concentrations were associated with dietary components,circulating atherogenic particles, and other risk factors for CVD, we divided the subjects into two groups: high HDL-C (H-HDL) (≥ 1.3 mmol/L,n = 32) and low HDL-C (L-HDL) (< 1.3 mmol/L, n = 57). Plasma lipids, insulin, adiponectin, apolipoproteins, oxidized LDL, Lipoprotein(a), and lipoprotein size and subfractions were measured, and 3-d dietary records were used to assess macronutrient intake. Women with L-HDL had higher sugar intake and glycemic load (P < 0.05), higher plasma insulin (P < 0.01), lower adiponectin (P < 0.05), and higher numbers of atherogenic lipoproteins such as large VLDL (P < 0.01) and small LDL (P < 0.001) than the H-HDL group. Women with L-HDL also had larger VLDL and both smaller LDL and HDL particle diameters (P < 0.001). HDL-C was positively correlated with LDL size (r = 0.691, P < 0.0001) and HDL size (r = 0.606,P < 0.001), and inversely correlated with VLDL size (r = -0.327, P < 0.01). We concluded that L-HDL could be used as a marker for increased numbers of circulating atherogenic lipoproteins as well as increased insulin resistance in women who are already at risk for CVD.
참고문헌 (37)
- National Cholesterol Education Program (NCEP), "Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) final report", Circulation, 106, pp.3143~3421 (2002)
- Fernandez ML, "The Metabolic Syndrome", Nutr Rev, 65, pp.S30~S34 (2007)
- Zhang B, "Predicted coronary risk for adults with coronary heart disease and low HDL-C: an analysis from the US National Health and Nutrition Examination Survey", Curr Med Res Opin, 24, pp.2711~2717 (2008)
- Lee JY, "ATP-binding cassette transporter AI and its role in HDL formation", Curr Opin Lipidol, 16, pp.19~25 (2005)
- Rosenblat M, "Paraoxonases role in the prevention of cardiovascular diseases", Biofactors, 35, pp.98~104 (2009)
- Fitzgerald ML, "ABC transporters, atherosclerosis and inflammation", Atherosclerosis, 211, pp.361~370 (2010)
- Murphy AJ, "The anti inflammatory effects of high density lipoproteins", Curr Med Chem, 16, pp.667~675 (2009)
- Navab M, "HDL as a biomarker, potential therapeutic target, and therapy", Diabetes, 58, pp.2711~2717 (2009)
- Saddar S, "Signaling by the high-affinity HDL receptor scavenger receptor B type I", Arterioscler Thromb Vasc Biol, 30, pp.144~150 (2010)
- Volek JS, "Dietary carbohydrate restriction induces a unique metabolic state positively affecting atherogenic dyslipidemia, fatty acid partitioning and metabolic syndrome", Progress in Lipid Res, 47, pp.307~318 (2008)
- Al-Sarraj T, "Carbohydrate restriction as a first-line dietary intervention therapy effectively reduces the biomarkers of metabolic syndrome in Emirati adults", J Nutr, 139, pp.1667~1676 (2009)
- Mutungi G, "Dietary cholesterol from eggs increases HDL cholesterol in overweight men consuming a carbohydrate restricted diet", J Nutr, 138, pp.272~276 (2008)
- Wood RJ, "Carbohydrate restriction alters lipoprotein metabolism by modifying VLDL, LDL and HDL subfraction distribution and size in overweight men", J Nutr, 136, pp.384~389 (2006)
- Friedewald WT, "Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge", Clin Chem, 18, pp.499~502 (1972)
- Haffner SM, "The homeostasis model in the San Antonio Heart Study", Diabetes Care, 120, pp.1087~1092 (1997)
- Liu MY, "Multiplexed analysis of biomarkers related to obesity and the metabolic syndrome in human plasma, using the Luminex-100 system", Clin Chem, 51, pp.1102~1109 (2005)
- Hulthe J, "Circulating oxidized LDL is associated with subclinical atherosclerosis development and inflammatory cytokines (AIR Study)", Arterioscler Thromb Vasc Biol, 22, pp.1162~1167 (2002)
- Wood RJ, "Effects of a carbohydrate-restricted diet on emerging plasma markers for cardiovascular disease", Nutr Metab (Lond), 3, pp.19~ (2006)
- Ratliff JC, "Eggs modulate the inflammatory response to carbohydrate restricted diets in overweight men", Nutr Metab (Lond), 5, pp.6~ (2008)
- Jenkins DJ, "Glycemic index of foods: a physiological basis for carbohydrate exchange", Am J Clin Nutr, 34, pp.362~366 (1981)
- Lakshman R, "Is alcohol beneficial or harmful for cardioprotection", Genes Nutr, 5, pp.111~120 (2010)
- Denke MA, "Dietary fat, fatty acids and their effects on lipoproteins", Curr Atheroscler Rep, 8, pp.466~471 (2006)
- Cnop M, "Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex", Diabetologia, 46, pp.459~469 (2003)
- Hotta K, "Plasma concentrations of a novel, adiposespecific protein, adiponectin, in type 2 diabetic patients", Arterioscler Thromb Vasc Biol, 20, pp.1595~1599 (2000)
- Marotta T, "Triglyceride-to-HDL cholesterol ratio and metabolic syndrome as contributors to cardiovascular risk in overweight patients", Obesity (Silver Spring), 18, pp.1608~1613 (2010)
- Shachter NS, "Apolipoproteins C-I and C-III as important modulators of lipoprotein metabolism", Curr Opin Lipidol, 12, pp.297~304 (2001)
- Austin MA, "Atherogenic lipoprotein phenotype. A proposed genetic marker for coronary heart disease risk", Circulation, 82, pp.495~506 (1990)
- Yamashita T, "Arterial compliance, blood pressure, plasma leptin, and plasma lipids in women are improved with weight reduction equally with a meat-based diet and a plant-based diet", Metabolism, 47, pp.1308~1314 (1998)
- Millar JS, "Heterogeneity of apolipoprotein B-100-containing lipoproteins: what we have learnt from kinetic studies", Curr Opin Lipidol, 9, pp.197~202 (1998)
- Gianturco SH, "Apolipoprotein B-48 or Its Apolipoprotein B-100 Equivalent Mediates the Binding of Triglyceride-Rich lipoproteins to Their Unique Human Monocyte-Macrophage Receptor", Arterioscler Thromb Vasc Biol, 18, pp.968~976 (1998)
- Zambon A, "Relevance of hepatic lipase to the metabolism of triacylglycerol-rich lipoproteins", Biochem Soc Trans, 31, pp.1070~1074 (2003)
- Rashid S, "Mechanisms of HDL lowering in insulin resistant, hypertriglyceridemic states: the combined effect of HDL triglyceride enrichment and elevated hepatic lipase activity", Clin Biochem, 36, pp.421~429 (2003)
- Gardner CD, "Association of small low-density lipoprotein particles with the incidence of coronary artery disease in men and women", JAMA, 276, pp.875~881 (1996)
- Krauss RM, "Relationship of intermediate and low-density lipoprotein subspecies to risk of coronary heart disease", Am Heart J, 113, pp.578~582 (1987)
- Tall AR, "Cholesterol efflux pathways and other potential mechanisms involved in the athero-protective effect of high density lipoproteins", J Intern Med, 263, pp.256~273 (2008)
- Seman LJ, "Lipoprotein(a), homocysteine, and remnantlike particles: emerging risk factors", Curr Opin Cardiol, 14, pp.186~191 (1999)
- Itabe H, "Minimally modified LDL is an oxidized LDL enriched with oxidized phosphatidyl cholines", J Biochem, 134, pp.459~465 (2003)