Relationships between Serum Adiponectin with Metabolic Syndrome and Components of Metabolic Syndrome in Non-Diabetic Koreans: ARIRANG Study
2
조회
0
다운로드
3
인용
0
참고문헌
키워드
초록
Purpose: Growing evidence suggests that hypoadiponectinemia may play a significant role in the development of metabolic syndrome (MetS). Therefore, the relationships between serum adiponectin with MetS and components of MetS were investigated in non-diabetic samples of drawn from the Koreans general population. Materials and Methods: We performed a cross-sectional study in samples of older Koreans (age > 40 years) including 2,471 men and 3,463 women. MetS was defined according to the Asian modified criteria of the National Cholesterol Education Program Adult Treatment Panel III report. Serum adiponectin concentrations were measured by radioimmunoassay. Results: The median adiponectin level in MetS was significantly lower than that in non-MetS subjects in men (6.00 vs. 8.00 μg/mL, p < 0.001) and women (10.12 vs. 11.74 μg/mL, p < 0.001). Adiponectin concentration was negatively correlated with waist circumference and levels of triglyceride, C-reactive protein (CRP), fasting glucose, and insulin, and positively correlated with high-density lipoprotein and age in both genders (p < 0.001). In a multivariate regression model after adjustment for age, body mass index,smoking, CRP, and lipid profiles, the odds ratio of MetS comparing extreme quartiles of adiponectin distribution was 0.32 [95% confidence interval (CI), 0.20 to 0.50] in men and 0.57 (95% CI, 0.43 to 0.76) in women. Conclusion: Adiponectin levels are independently associated with the phenotype of MetS, as well as components of MetS in the non-diabetic Korean general population.
Abstract
Purpose: Growing evidence suggests that hypoadiponectinemia may play a significant role in the development of metabolic syndrome (MetS). Therefore, the relationships between serum adiponectin with MetS and components of MetS were investigated in non-diabetic samples of drawn from the Koreans general population. Materials and Methods: We performed a cross-sectional study in samples of older Koreans (age > 40 years) including 2,471 men and 3,463 women. MetS was defined according to the Asian modified criteria of the National Cholesterol Education Program Adult Treatment Panel III report. Serum adiponectin concentrations were measured by radioimmunoassay. Results: The median adiponectin level in MetS was significantly lower than that in non-MetS subjects in men (6.00 vs. 8.00 μg/mL, p < 0.001) and women (10.12 vs. 11.74 μg/mL, p < 0.001). Adiponectin concentration was negatively correlated with waist circumference and levels of triglyceride, C-reactive protein (CRP), fasting glucose, and insulin, and positively correlated with high-density lipoprotein and age in both genders (p < 0.001). In a multivariate regression model after adjustment for age, body mass index,smoking, CRP, and lipid profiles, the odds ratio of MetS comparing extreme quartiles of adiponectin distribution was 0.32 [95% confidence interval (CI), 0.20 to 0.50] in men and 0.57 (95% CI, 0.43 to 0.76) in women. Conclusion: Adiponectin levels are independently associated with the phenotype of MetS, as well as components of MetS in the non-diabetic Korean general population.
참고문헌 (31)
- Ouchi N, "Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin", Circulation, 100, pp.2473~2476 (1999)
- Okui H, "Adiponectin is a better predictor of endothelial function of the coronary artery than HOMA-R, body mass index, immunoreactive insulin, or triglycerides", Int J Cardiol, 126, pp.53~61 (2008)
- Matsushita K, "Further inflammatory information on metabolic syndrome by adiponectin evaluation", Int J Cardiol, 124, pp.339~344 (2008)
- Matsuzawa Y, "Adiponectin and metabolic syndrome", Arterioscler Thromb Vasc Biol, 24, pp.29~33 (2004)
- Whitehead JP, "Adiponectin--a key adipokine in the metabolic syndrome", Diabetes Obes Metab, 8, pp.264~280 (2006)
- National Cholesterol Educution Program (NCEP) Expert Panel on Detection, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III), "Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report", Circulation, 106, pp.3143~3421 (2002)
- "World Health Organization Western Pacific Region International Obesity Task Force. The Asia-Pacific perspective: redifing obesity and its treatment, Sydney. Heath Communications Australia Pty Limited", ~ (2000)
- Alberti KG, "IDF Epidemiology Task Force Consensus Group. The metabolic syndrome--a new worldwide definition", Lancet, 366, pp.1059~1062 (2005)
- Berg AH, "Adipose tissue, inflammation, and cardiovascular disease", Circ Res, 96, pp.939~949 (2005)
- Koerner A, "Adipocytokines: leptin--the classical, resistin--the controversial, adiponectin--the promising, and more to come", Best Pract Res Clin Endocrinol Metab, 19, pp.525~546 (2005)
- Kim SM, "Relationship between plasma adiponectin levels and the metabolic syndrome among Korean people", ENDOCRINE JOURNAL, 53(2), pp.247~254 (2006), JAPAN ENDOCRINE SOCIETY
- Mohan V, "Association of low adiponectin levels with the metabolic syndrome--the Chennai Urban Rural Epidemiology Study (CURES-4)", Metabolism, 54, pp.476~481 (2005)
- Ryo M, "Adiponectin as a biomarker of the metabolic syndrome", Circ J, 68, pp.975~981 (2004)
- Nishizawa H, "Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein", Diabetes, 51, pp.2734~2741 (2002)
- Cnop M, "Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex", Diabetologia, 46, pp.459~469 (2003)
- Ohashi K, "Adiponectin replenishment ameliorates obesity-related hypertension", Hypertension, 47, pp.1108~1116 (2006)
- Adamczak M, "Decreased plasma adiponectin concentration in patients with essential hypertension", Am J Hypertens, 16, pp.72~75 (2003)
- Furuhashi M, "Blockade of the renin-angiotensin system increases adiponectin concentrations in patients with essential hypertension", Hypertension, 42, pp.76~81 (2003)
- Mallamaci F, "Adiponectin in essential hypertension", J Nephrol, 15, pp.507~511 (2002)
- Yang WS, "Plasma adiponectin levels in overweight and obese Asians", Obes Res, 10, pp.1104~1110 (2002)
- Aizawa Y, "Cardiovascular risk factors are really linked in the metabolic syndrome: this phenomenon suggests clustering rather than coincidence", Int J Cardiol, 109, pp.213~218 (2006)
- Edwards KL, "Factors of the insulin resistance syndrome in nondiabetic and diabetic elderly Japanese-American men", Am J Epidemiol, 147, pp.441~447 (1998)
- Meigs JB, "Risk variable clustering in the insulin resistance syndrome. The Framingham Offspring Study", Diabetes, 46, pp.1594~1600 (1997)
- Sattar N, "Metabolic syndrome with and without C-reactive protein as a predictor of coronary heart disease and diabetes in the West of Scotland Coronary Prevention Study", Circulation, 108, pp.414~419 (2003)
- Malik S, "Impact of the metabolic syndrome on mortality from coronary heart disease, cardiovascular disease, and all causes in United States adults", Circulation, 110, pp.1245~1250 (2004)
- Wannamethee SG, "Adipokines and risk of type 2 diabetes in older men", Diabetes Care, 30, pp.1200~1205 (2007)
- Snijder MB, "Associations of adiponectin levels with incident impaired glucose metabolism and type 2 diabetes in older men and women: the hoorn study", Diabetes Care, 29, pp.2498~2503 (2006)
- Pischon T, "Plasma adiponectin levels and risk of myocardial infarction in men", JAMA, 291, pp.1730~1737 (2004)
- Laughlin GA, "Association of adiponectin with coronary heart disease and mortality: the Rancho Bernardo study", Am J Epidemiol, 165, pp.164~174 (2007)
- Wannamethee SG, "Circulating adiponectin levels and mortality in elderly men with and without cardiovascular disease and heart failure", Arch Intern Med, 167, pp.1510~1517 (2007)
- Rothenbacher D, "Adiponectin, risk of coronary heart disease and correlations with cardiovascular risk markers", Eur Heart J, 26, pp.1640~1646 (2005)