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Higher levels of serum triglyceride and dietary carbohydrate intake are associated with smaller LDL particle size in healthy Korean women

정혜경|신민정|김오연
한국영양학회 (The Korean Nutrition Society)|2012.04|Nutrition Research and Practice|제6권 제2호|pp. 120-125|DOI http://dx.doi.org/10.4162/nrp.2012.6.2.120

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키워드

triglycerideLDL particle sizedietary carbohydrateLDL phenotype

초록

The aim of this study was to investigate the influencing factors that characterize low density lipoprotein (LDL) phenotype and the levels of LDL particle size in healthy Korean women. In 57 healthy Korean women (mean age, 57.4 ± 13.1 yrs), anthropometric and biochemical parameters such as lipid profiles and LDL particle size were measured. Dietary intake was estimated by a developed semi-quantitative food frequency questionnaire. The study subjects were divided into two groups: LDL phenotype A (mean size: 269.7Å, n = 44) and LDL phenotype B (mean size: 248.2Å,n = 13). Basic characteristics were not significantly different between the two groups. The phenotype B group had a higher body mass index, higher serum levels of triglyceride, total-cholesterol, LDL-cholesterol, apolipoprotein (apo)B, and apoCIII but lower levels of high density lipoprotein (HDL)-cholesterol and LDL particle size than those of the phenotype A group. LDL particle size was negatively correlated with serum levels of triglyceride (r = -0.732, P < 0.001), total-cholesterol, apoB, and apoCIII, as well as carbohydrate intake (%En) and positively correlated with serum levels of HDL-cholesterol and ApoA1 and fat intake (%En). A stepwise multiple linear regression analysis revealed that carbohydrate intake (%En)and serum triglyceride levels were the primary factors influencing LDL particle size (P < 0.001, R2 = 0.577). This result confirmed that LDL particle size was closely correlated with circulating triglycerides and demonstrated that particle size is significantly associated with dietary carbohydrate in Korean women.

Abstract

The aim of this study was to investigate the influencing factors that characterize low density lipoprotein (LDL) phenotype and the levels of LDL particle size in healthy Korean women. In 57 healthy Korean women (mean age, 57.4 ± 13.1 yrs), anthropometric and biochemical parameters such as lipid profiles and LDL particle size were measured. Dietary intake was estimated by a developed semi-quantitative food frequency questionnaire. The study subjects were divided into two groups: LDL phenotype A (mean size: 269.7Å, n = 44) and LDL phenotype B (mean size: 248.2Å,n = 13). Basic characteristics were not significantly different between the two groups. The phenotype B group had a higher body mass index, higher serum levels of triglyceride, total-cholesterol, LDL-cholesterol, apolipoprotein (apo)B, and apoCIII but lower levels of high density lipoprotein (HDL)-cholesterol and LDL particle size than those of the phenotype A group. LDL particle size was negatively correlated with serum levels of triglyceride (r = -0.732, P < 0.001), total-cholesterol, apoB, and apoCIII, as well as carbohydrate intake (%En) and positively correlated with serum levels of HDL-cholesterol and ApoA1 and fat intake (%En). A stepwise multiple linear regression analysis revealed that carbohydrate intake (%En)and serum triglyceride levels were the primary factors influencing LDL particle size (P < 0.001, R2 = 0.577). This result confirmed that LDL particle size was closely correlated with circulating triglycerides and demonstrated that particle size is significantly associated with dietary carbohydrate in Korean women.

참고문헌 (34)

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관련 논문AI추천

Blood Triglycerides Levels and Dietary Carbohydrate Indices in Healthy Koreans강지연, 김미경, 민혜숙, 성주헌대한예방의학회 · 예방의학회지2016 · 제49권 제3호Association between Dietary Carbohydrate Intake and Cardiovascular Risk Factors According to Low-Density Lipoprotein Cholesterol Levels in Korean Adults송수진, 송윤주, 이윤정대한임상건강증진학회 · Korean Journal of Health Promotion2020 · 제20권 제4호Hypertriglyceridemia is a Major Factor Associated With Elevated Levels of Small Dense LDL Cholesterol in Patients With Metabolic Syndrome김정호, 이상국, 조용근, 지선하대한진단검사의학회 · Annals of Laboratory Medicine2015 · 제35권 제6호Low HDL cholesterol is associated with increased atherogenic lipoproteins and insulin resistance in women classified with metabolic syndromeCatherine Andersen, Colleen Kalynych, Daniela Ackerman, Jacqueline Barona, Jeff S Volek, Jennifer J Jones, Jose O Leite, Jung-Eun Kim, Maria Luz Fernandez, Mariana Calle, Mark McIntosh, Michael V Comperatore, Robert H Lerman, Wadie Najm한국영양학회 · Nutrition Research and Practice2010 · 제4권 제6호Gender Difference in the Level of HDL Cholesterol in Korean Adults강재헌, 강주호, 김경우, 김누리, 김철환, 김혜진, 박진균, 박현아, 정원진, 조영규, 황동희대한가정의학회 · Korean Journal of Family Medicine2011 · 제32권 제3호Comparison of time course changes in blood glucose, insulin and lipids between high carbohydrate and high fat meals in healthy young women박수진, 신유미, 조여원한국영양학회 · Nutrition Research and Practice2009 · 제3권 제2호

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