The Relationship between the Triglyceride to High-Density Lipoprotein Cholesterol Ratio and Metabolic Syndrome
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background: Metabolic syndrome is associated with cardiovascular diseases and is characterized by insulin resistance. Recent studies suggest that the triglyceride/high-density lipoprotein cholesterol (TG/HDLC) ratio predictsinsulin resistance better than individual lipid levels, including TG, total cholesterol, low-density lipoprotein cholesterol(LDLC), or HDLC. We aimed to elucidate the relationship between the TG/HDLC ratio and metabolic syndromein the general Korean population. Methods: We evaluated the data of adults ≥20 years old who were enrolled in the Korean National Health and NutritionExamination Survey in 2013 and 2014. Subjects with angina pectoris, myocardial infarction, stroke, or cancerwere excluded. Metabolic syndrome was defined by the harmonized definition. We examined the odds ratios (ORs)of metabolic syndrome according to TG/HDLC ratio quartiles using logistic regression analysis (SAS ver. 9.4; SASInstitute Inc., Cary, NC, USA). Weighted complex sample analysis was also conducted. Results: We found a significant association between the TG/HDLC ratio and metabolic syndrome. The cutoff valueof the TG/HDLC ratio for the fourth quartile was ≥3.52. After adjustment, the OR for metabolic syndrome in thefourth quartile compared with that of the first quartile was 29.65 in men and 20.60 in women (P<0.001). Conclusion: The TG/HDLC ratio is significantly associated with metabolic syndrome.
Abstract
Background: Metabolic syndrome is associated with cardiovascular diseases and is characterized by insulin resistance. Recent studies suggest that the triglyceride/high-density lipoprotein cholesterol (TG/HDLC) ratio predictsinsulin resistance better than individual lipid levels, including TG, total cholesterol, low-density lipoprotein cholesterol(LDLC), or HDLC. We aimed to elucidate the relationship between the TG/HDLC ratio and metabolic syndromein the general Korean population. Methods: We evaluated the data of adults ≥20 years old who were enrolled in the Korean National Health and NutritionExamination Survey in 2013 and 2014. Subjects with angina pectoris, myocardial infarction, stroke, or cancerwere excluded. Metabolic syndrome was defined by the harmonized definition. We examined the odds ratios (ORs)of metabolic syndrome according to TG/HDLC ratio quartiles using logistic regression analysis (SAS ver. 9.4; SASInstitute Inc., Cary, NC, USA). Weighted complex sample analysis was also conducted. Results: We found a significant association between the TG/HDLC ratio and metabolic syndrome. The cutoff valueof the TG/HDLC ratio for the fourth quartile was ≥3.52. After adjustment, the OR for metabolic syndrome in thefourth quartile compared with that of the first quartile was 29.65 in men and 20.60 in women (P<0.001). Conclusion: The TG/HDLC ratio is significantly associated with metabolic syndrome.
참고문헌 (28)
- Isomaa B, "Cardiovascular morbidity and mortality associated with the metabolic syndrome", Diabetes Care, 24, pp.683~689 (2001)
- Lakka HM, "The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men", JAMA, 288, pp.2709~2716 (2002)
- Wheatcroft SB, "Pathophysiological implications of insulin resistance on vascular endothelial function", Diabet Med, 20, pp.255~268 (2003)
- DeFronzo RA, "Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease", Diabetes Care, 14, pp.173~194 (1991)
- Kahn BB, "Obesity and insulin resistance", J Clin Invest, 106, pp.473~481 (2000)
- Kahn SE, "Mechanisms linking obesity to insulin resistance and type 2 diabetes", Nature, 444, pp.840~846 (2006)
- Egger M, "Triglyceride as a risk factor for ischaemic heart disease in British men : effect of adjusting for measurement error", Atherosclerosis, 143, pp.275~284 (1999)
- Sharrett AR, "Coronary heart disease prediction from lipoprotein cholesterol levels, triglycerides, lipoprotein(a), apolipoproteins A-I and B, and HDL density subfractions: the Atherosclerosis Risk in Communities (ARIC) Study", Circulation, 104, pp.1108~1113 (2001)
- Shah PK, "Exploiting the vascular protective effects of high-density lipoprotein and its apolipoproteins: an idea whose time for testing is coming, part I", Circulation, 104, pp.2376~2383 (2001)
- Ogushi Y, "Blood cholesterol as a good marker of health in Japan", World Rev Nutr Diet, 100, pp.63~70 (2009)
- McLaughlin T, "Use of metabolic markers to identify overweight individuals who are insulin resistant", Ann Intern Med, 139, pp.802~809 (2003)
- McLaughlin T, "Is there a simple way to identify insulin-resistant individuals at increased risk of cardiovascular disease?", Am J Cardiol, 96, pp.399~404 (2005)
- Kim JS, "The association between the triglyceride to high-density lipoprotein cholesterol ratio with insulin resistance(HOMA-IR)in the general Korean population : based on the National Health and Nutrition Examination Survey in 2007-2009", Diabetes Res Clin Pract, 97, pp.132~138 (2012)
- De Leon AC, "Impaired fasting glucose, ancestry and waist-to-height ratio: main predictors of incident diagnosed diabetes in the Canary Islands", Diabet Med, 29, pp.399~403 (2012)
- Hadaegh F, "Triglyceride", HDL-cholesterol ratio is an independent predictor for coronary heart disease in a population of Iranian men, 2009, pp.19, 401~408
- Liang J, "TriGlycerides and highdensity lipoprotein cholesterol ratio compared with homeostasis model assessment insulin resistance indexes in screening for metabolic syndrome in the Chinese obese children : a cross section study", BMC Pediatr, 15, pp.138~ (2015)
- Alberti KG, "Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute;American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity", Circulation, 120, pp.1640~1645 (2009)
- Salazar MR, "Comparison of the abilities of the plasma triglyceride", high-density lipoprotein cholesterol ratio and the metabolic syndrome to identify insulin resistance, 2013, pp.10, 346~352
- Sung KC, "Ability of the plasma concentration ratio of triglyceride", high-density lipoprotein cholesterol to identify increased cardio-metabolic risk in an East Asian population, 2014, pp.105, 96~101
- 김미경, "2014 Clinical Practice Guidelines for Overweight and Obesity in Korea", Journal of Obesity & Metabolic Syndrome, 23(4), pp.217~221 (2014), 대한비만학회
- Oh SY, "Relationship between metabolic syndrome and triglyceride", high-density lipoprotein cholesterol ratio, 2014, pp.15, 69~74
- Flegal KM, "Association of all-cause mortality with overweight and obesity using standard body mass index categories : a systematic review and meta-analysis", JAMA, 309, pp.71~82 (2013)
- Sahakyan KR, "Normal-weight central obesity : implications for total and cardiovascular mortality", Ann Intern Med, 163, pp.827~835 (2015)
- Dobiasova M, "The plasma parameter log(TG", HDL-C)as an atherogenic index : correlation with lipoprotein particle size and esterification rate in apoB-lipoprotein-depleted plasma(FERHDL), 2001, pp.34, 583~588
- Hanak V, "Accuracy of the triglyceride to high-density lipoprotein cholesterol ratio for prediction of the low-density lipoprotein phenotype B", Am J Cardiol, 94, pp.219~222 (2004)
- Austin MA, "Low-density lipoprotein subclass patterns and risk of myocardial infarction", JAMA, 260, pp.1917~1921 (1988)
- Crouse JR, "Studies of low density lipoprotein molecular weight in human beings with coronary artery disease", J Lipid Res, 26, pp.566~574 (1985)
- Wen JH, "Triglyceride to HDL-C ratio and increased arterial stiffness in apparently healthy individuals", Int J Clin Exp Med, 8, pp.4342~4348 (2015)
