Comparison of time course changes in blood glucose, insulin and lipids between high carbohydrate and high fat meals in healthy young women
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Few studies have examined short term responses to the different contents of carbohydrate or fat in the meal, although long term effects of the high fat meal have been considered as compound risk factor for metabolic disorders. The aim of this study was to investigate the postprandial changes of plasma glucose, insulin and lipids upon intakes of high carbohydrate or high fat meal in young healthy women. Subjects were randomly assigned to either the high carbohydrate meal (HCM, 75% carbohydrate, n=13) or the high fat meal (HFM, 60% fat, n=12) groups. The meals were prepared as isocaloric typical Korean menu. Blood samples were obtained prior to and 30, 60, 90, 120, 180 and 240 minute after the meal. There were no significant differences on fasting blood parameters including glucose, insulin, lipids concentrations between the groups prior to the test. The HCM had higher blood glucose and insulin concentrations, reached the peak at 30 min and maintained for 240 min compared to the HFM (P<0.05). The HFM had higher plasma triglyceride (TG) and free fatty acid (FFA) concentrations, reached the peak at 120 min and maintained for 240 min compared to the HCM (P<0.05). It is concluded that macronutrients content in the meal may be an important determinant of postprandial substrate utilization in healthy women.
Abstract
Few studies have examined short term responses to the different contents of carbohydrate or fat in the meal, although long term effects of the high fat meal have been considered as compound risk factor for metabolic disorders. The aim of this study was to investigate the postprandial changes of plasma glucose, insulin and lipids upon intakes of high carbohydrate or high fat meal in young healthy women. Subjects were randomly assigned to either the high carbohydrate meal (HCM, 75% carbohydrate, n=13) or the high fat meal (HFM, 60% fat, n=12) groups. The meals were prepared as isocaloric typical Korean menu. Blood samples were obtained prior to and 30, 60, 90, 120, 180 and 240 minute after the meal. There were no significant differences on fasting blood parameters including glucose, insulin, lipids concentrations between the groups prior to the test. The HCM had higher blood glucose and insulin concentrations, reached the peak at 30 min and maintained for 240 min compared to the HFM (P<0.05). The HFM had higher plasma triglyceride (TG) and free fatty acid (FFA) concentrations, reached the peak at 120 min and maintained for 240 min compared to the HCM (P<0.05). It is concluded that macronutrients content in the meal may be an important determinant of postprandial substrate utilization in healthy women.
참고문헌 (24)
- Cohen JC, "Effects of glucose ingestion on postprandial lipemia and triglyceride clearance in humans", J Lipid Res, 31, pp.597~602 (1990)
- Coulston AM, "Plasma glucose, insulin and lipid responses to high-carbohydrate low-fat diets in normal humans", Metabolism, 32, pp.52~56 (1983)
- Dubois C, "Effects of graded amounts (0-50 g) of dietary fat on postprandial lipemia and lipoproteins in normolipidemic adults", Am J Clin Nutr, 49, pp.578~588 (1998)
- Gougeon R, "The impact of lowcarbohydrate diets on glycemic control and weight management in patients with type 2 diabetes", Canadian Journal of Diabetese, 30, pp.269~277 (2006)
- Grant KI, "Sucrose in a lipid-rich meal amplifies the postprandial excursion of serum and lipoprotein triglyceride and cholesterol concentrations by decreasing triglyceride clearance", Am J Clin Nutr, 59, pp.853~860 (1994)
- Harbis A, "Glycemic and insulinemic meal responses modulate postprandial hepatic and intestinal lipoprotein accumulation in obese, insulin-resistant subjects", Am J Clin Nutr, 80, pp.896~902 (2004)
- Katz A, "Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans", J Clin Endocrinol Metab, 85, pp.2402~2410 (2000)
- 권숙정, "공복혈당장애군 및 당뇨군의 비만도, 혈압, 혈청 지질 농도 및 영양소 섭취 상태", 한국영양학회지, 35(3), pp.303~313 (2002), 한국영양학회
- Laaksonen DE, "Dietary carbohydrate modification enhances insulin secretion in persons with the metabolic syndrome", Am J Clin Nutr, 82, pp.1218~1227 (2005)
- Liu B, "Effect of high carbohydrate and high fat diets on plasma glucose, insulin and lipids in normal and hypertriglyceridemic subjects", Hua Xi Yi Ke Da Xue Xue Bao, 21, pp.145~149 (1990)
- Liu GC, "Effect of highcarbohydrate-low-fat diets on plasma glucose, insulin and lipid responses in hypertriglyceridemic humans", Metabolism, 32, pp.750~753 (1983)
- Lopez-Miranda J, "Dietary, physiological, genetic and pathological influences on postprandial lipid metabolism", Br J Nutr, 98, pp.458~473 (2007)
- Mattews DR, "Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man", Diabetologia, 28, pp.412~419 (1985)
- McAuley KA, "Comparison of high fat and high protein diets with a high carbohydrate diet in insulin-resistant obese women", Diabetologia, 48, pp.8~16 (2005)
- McGregor IS, "Metabolic changes associated with ingestion of different macronutrients and different meal sizes in rats", Physiol Behav, 57, pp.277~286 (1995)
- Park EJ, "Effects of a low-fat, high-carbohydrate diet on VLDLtriglyceride assembly, production, and clearance", J Clin Invest, 104, pp.1087~1096 (1999)
- Ryu MH, "The effects of a high-fat or high sucrose diet on serum lipid profiles, hepatic acyl-CoA synthetase, carnitine palmitoyltransferase-1, and the acetyl-CoA carboxylase mRNA levels in rats", J Biochem Mol, 36, pp.312~318 (2003)
- Sargrad KR, "Effect of high protein vs high carbohydrate intake on insulin sensitivity, body weight, hemoglobinA1c, and blood pressure in patients with type 2 diabetes mellitus", J Am Diet Assoc, 105, pp.573~580 (2005)
- Shai I, "Weight loss with a low-carbohydrate, Mediterranean, or low-fat diet", N Engl J Med, 359, pp.229~241 (2008)
- Sharman MJ, "Very low-carbohydrate and low-fat diets affect fasting lipids and postprandial lipemia differently in overweight men", J Nutr, 134, pp.880~885 (2004)
- Volek JS, "Carbohydrate restriction improves the features of Metabolic Syndrome. Metabolic Syndrome may be defined by the response to carbohydrate restriction", Nutr Metab, 2, pp.31~ (2005)
- Wareham NJ, "The 30 minute insulin incremental response in an oral glucose tolerance test as a measure of insulin secretion", Diabet Med, 12, pp.931~ (1995)
- Yang EJ, "Carbohydrate intake and biomarkers of glycemic control among US adults: the third National Health and Nutrition Examination Survey (NHANES III)", Am J Clin Nutr, 77, pp.1426~1433 (2003)
- Yoon SG, "Glycemic responses of Korean domestic meals and diabetic meals in normal subjects", The Kor J Food and Nutr, 11, pp.303~311 (1998)