Safflower Bud Dietary Prevents Ovariectomy-induced Osteoporosis in Rats
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초록
Safflower (Carthamus tinctorius L.) seeds have long been clinically used in Korea to promote bone formation and prevent osteoporosis. In addition, the safflower buds (SB) were found to have more useful functional ingredients than safflower seed. Thus, we investigated the preventive effects of SB diet in ovariectomized (OVX) rats. The rats were divided into five groups; sham operated group, OVX alone group, OVX plus 17β-estradiol (E2 10 ㎍/㎏, i.p.) and OVX plus SB diet feeding group (0.3% or 1%). Feeding of SB diet (0.3% or 3%) to OVX rats markedly increased trabecular formation in femur compared to OVX rats. Feeding of SB diet (0.3% or 3%) to OVX rats also decreased TRAP activity compared to OVX rats. These results suggest that SB diets have bone sparing effects by the decrease of osteoclast activity. We also observed that OVX rats fed with SB diet (0.3% or 3%) exhibited the decrease of calcium and phosphorus in serum compared to OVX-induced rats. Therefore, SB may be beneficial for the patients of osteoporosis, especially in postmenopausal women.
Abstract
Safflower (Carthamus tinctorius L.) seeds have long been clinically used in Korea to promote bone formation and prevent osteoporosis. In addition, the safflower buds (SB) were found to have more useful functional ingredients than safflower seed. Thus, we investigated the preventive effects of SB diet in ovariectomized (OVX) rats. The rats were divided into five groups; sham operated group, OVX alone group, OVX plus 17β-estradiol (E2 10 ㎍/㎏, i.p.) and OVX plus SB diet feeding group (0.3% or 1%). Feeding of SB diet (0.3% or 3%) to OVX rats markedly increased trabecular formation in femur compared to OVX rats. Feeding of SB diet (0.3% or 3%) to OVX rats also decreased TRAP activity compared to OVX rats. These results suggest that SB diets have bone sparing effects by the decrease of osteoclast activity. We also observed that OVX rats fed with SB diet (0.3% or 3%) exhibited the decrease of calcium and phosphorus in serum compared to OVX-induced rats. Therefore, SB may be beneficial for the patients of osteoporosis, especially in postmenopausal women.
참고문헌 (18)
- Alam, M.R, "Effects of safflower seed oil in osteoporosis induced-ovariectomized rats", Am. J. Chin. Med, 34, pp.601~612 (2006)
- Bae, S.J, "Cytotoxicity of phenolic compounds isolated from seeds of safflower (Carthamus tiractorious L.) on cancer cell lines", Food Sci. Biotechnol, 11, pp.140~146 (2002)
- Brennan, O, "Temporal changes in bone composition, architecture, and strength following estrogen deficiency in osteoporosis", Calcif. Tissue Int, 91, pp.440~449 (2012)
- Cauley, J.A, "Risk of mortality following clinical fractures", Osteoporos. Int, 11, pp.556~561 (2000)
- Cummings, S.R, "Epidemiology and outcomes of osteoporotic fractures", Lancet, 359, pp.1761~1767 (2002)
- Hiramatsu, M, "Antioxidant and neuroprotective activities of Mogami-benibana (safflower, Carthamus tinctorius L.)", Neurochem. Res, 34, pp.795~805 (2009)
- Holzer, G, "Soluble cathepsin K: a novel marker for the prediction of nontraumatic fractures", J. Lab. Clin. Med, 146(1), pp.13~17 (2005)
- Kalu, D.N, "The ovariectomized rat model of postmenopausal bone loss", Bone Miner, 15(3), pp.175~191 (1991)
- 김효진, "Anti-osteoporotic Effects of Unripe Fructus of Rubus coreanus Miquel in Osteoblastic and Osteoclastic Cells", 한국자원식물학회지, 27(6), pp.593~600 (2014), 한국자원식물학회[DOI]
- Kim, H.Y, "The effect of safflower seed extract on periodontal healing of 1-wall intrabony defects in beagle dogs", J. Periodontol, 73, pp.1457~1466 (2002)
- Lelovas, P.P, "The laboratory rat as an animal model for osteoporosis research", Comp. Med, 58, pp.424~430 (2008)
- Kneissel., M, "Everolimus suppresses cancellous bone loss, bone resorption, and cathepsin K expression by osteoclasts", Bone, 35(5), pp.1144~1156 (2004)
- Osterhoff, G, "Influence of trabecular microstructure and cortical index on the complexity of proximal humeral fractures", Arch. Orthop. Trauma. Surg, 132(4), pp.509~515 (2012)
- Qin, D.W, "Protective effects of gallium, germanium, and strontium against ovariectomized osteoporosis in rats", Biol. Trace Elem. Res, 153(1-3), pp.350~354 (2013)
- Rahman, M.M, "Conjugated linoleic acid prevents ovariectomy-induced bone loss in mice by modulating both osteoclastogenesis and osteoblastogenesis", Lipids, 49(3), pp.211~224 (2014)
- Seo, H.J, "The effects of safflower seed powder and its fraction on bone tissue in rib-fractured rats during the recovery", Korean J. Nutr, 33, pp.441~420 (2000)
- Wensel, T.M, "Effects of denosumab on bone mineral density and bone turnover in postmenopausal women", Pharmacotherapy, 31(5), pp.510~523 (2011)
- Yogesh, H.S, "Anti-osteoporotic activity of aqueous-methanol extract of Berberis aristata in ovariectomized rats", J. Ethnopharmacol, 134(2), pp.334~338 (2011)