홍화씨 Yoghurt 급여가 난소절제 Rat의 골다공증에 미치는 영향

Abstract

This study was performed to investigate the effect of safflower(Carthamus tinctorius L.) seed yoghurt on osteoporosis. Sham-operated rats(control) were fed basal diet for 6 weeks. Ovariectomized rats were divided into 6 different experimental groups including basal diet group(GⅠ), yoghurt diet group(GⅡ) and 1% to 4% safflower seed yoghurt diet group(GⅢ to GⅥ), and fed with the experimental diet for 6 weeks, respectively. The feed intake, feed efficiency ratio and body weight gains of rats fed with the experimental diet for 6 weeks were analyzed, respectively, and the weight, length, strength, mineral content and density in left femur of the animals were determined, respectively. Also, the right femur tissues were observed by Scanning Electron Microscope(SEM). The level of feed intake was not different among all experimental groups. The feed efficiency ratio and body weight gain were high in safflower seed yoghurt groups, and GⅤ and GⅥ appeared high specially. Density, strength, ash content and minerals content in left femur were similar between control and GⅠ, and increased with increasing the amount of safflower seed in yoghurt. On the other hand, weight and length in left femur showed no difference among all experimental groups. From the results of SEM observation of right femur tissue, GⅥ showed high healing effects. From the results of this experiment the healing effects of safflower seed yoghurt diet group were higher than those of control and GⅠ. Among the treatments, GⅥ showed the highest healing effects on the osteoporosis in ovariectomized rats.