Effects of silkworm pupae on bone mineral density in ovariectomized rat model of osteoporesis
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초록
Osteoporosis is characterized by the reduced density of mineralized bone matrix. The loss of bone has been attributed to an imbalance between bone formation and bone resorption. The silkmoth is one of the famous traditional tonic medicines. Silkworm pupa was evaluated for its antiosteoporotic activity in an ovariectomized rat model of osteoporosis. The rats were ovariectomized at 6weeks of age and divided into 7 groups. All the groups were fed without calcium diet. The OVX rats were treated with water and silkworm powder for 6 weeks. In OVX rats, the body weight, feeding and water intake quantity did not show a significant change, but the silkworm pupa powder immediately before the eclosion of Yeonrokjam was significantly increased the bone mineral density in the femoral bone. The silkworm pupa powder increased the bone with increasing calcium in serum. These results also showed its protective action through promotion of bone formation. The silkworm pupa powder has a definite antiosteoporotic effect; similar to estrogen, it is especially effective for the prevention of bone fracture induced by estrogen deficiency. The silkworm pupa powder is a promising anti-osteoporotic agent that can prevent bone fractures in osteoporotic patients. The silkworm pupa powder does not show serious side effects because natural herbal medicine origin.
Abstract
Osteoporosis is characterized by the reduced density of mineralized bone matrix. The loss of bone has been attributed to an imbalance between bone formation and bone resorption. The silkmoth is one of the famous traditional tonic medicines. Silkworm pupa was evaluated for its antiosteoporotic activity in an ovariectomized rat model of osteoporosis. The rats were ovariectomized at 6weeks of age and divided into 7 groups. All the groups were fed without calcium diet. The OVX rats were treated with water and silkworm powder for 6 weeks. In OVX rats, the body weight, feeding and water intake quantity did not show a significant change, but the silkworm pupa powder immediately before the eclosion of Yeonrokjam was significantly increased the bone mineral density in the femoral bone. The silkworm pupa powder increased the bone with increasing calcium in serum. These results also showed its protective action through promotion of bone formation. The silkworm pupa powder has a definite antiosteoporotic effect; similar to estrogen, it is especially effective for the prevention of bone fracture induced by estrogen deficiency. The silkworm pupa powder is a promising anti-osteoporotic agent that can prevent bone fractures in osteoporotic patients. The silkworm pupa powder does not show serious side effects because natural herbal medicine origin.
참고문헌 (14)
- Arjmandi BH, "Dietary soybean protein pre-vents bone loss in an ovariectomized rat model of osteoporosis", J. Nutr, 126, pp.161~167 (1996)
- Canalis E, "Growth factors and the regulation on bone remodeling", J. Clin. Invest, 81, pp.277~281 (1988)
- Einhorn T, "Bone strength: the bottom line", Calcif. Tissue Int, 51, pp.333~339 (1992)
- Gao SQ, "Advances in the study on the treatment of osteoporosis with Herba Epimedii and its compound prescriptions", China J. Chin. Mater. Med, 24, pp.249~251 (1999)
- Genant HK, "Estrogens in the prevention of osteoporosis in postmenopausal women", Am. J. Obstet. Gynaecol, 161, pp.1842~1846 (1998)
- Gorman C, "About hormones", Time, 36~37 (2002)
- Ke HZ, "Comparative effects of droloxifene, tamoxifen, and estrogenon bone, serum cholesterol, and uterine histology in the ovariectomized rat model", Bone, 20, pp.31~39 (1997)
- Kelly PJ, "Is osteoporosis a genetically determined disease?", Br. J. Obstet. Gynaecol, 103, pp.20~27 (1996)
- Li QN, "Epimedium sagittatum Maxim, preventing hormone- induced osteoporosis in rats", Chin. Pharm. J, 31, pp.467~470 (1996)
- Ma HP, "Studies on the theraputic effect of total flavonoids of Herba Epimedii on experimental osteoporosis in rats", Huaxi J. Pharm., 17, pp.163~167 (2002)
- Maddox RW, "Estrogen and postmenopausal women", US Pharmacist, 23, pp.141~150 (1998)
- KangSunRyu, "The Tonic Effect of the Extract from Male Silkworm (Bombyx mori L.) Pupae on Rats", International Journal of Industrial Entomology, 5(1), pp.123~126 (2002), 한국잠사학회
- Kang-Sun Ryu, "Secretion Effect of Estrogen of Different Growth Stages of Silkworm (Bombyx mori L.)", International Journal of Industrial Entomology, 22(1), pp.17~20 (2011), 한국잠사학회
- Wehren LE, "The epidemiology of osteoporosis and fractures in geriatric medicine", Clin. Geriatr. Med., 19, pp.245~258 (2003)