시스플라틴 유도 체중감소에 대한 반하사심탕 추출물의 방어효과
Inhibitory Effects of Banhasasim-tang Extracts on Cisplatin-induced Body Weight Decrease in Mouse Model
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
In this study, Banhasasim-tang extracts (BSTE) have an inhibitory effects on cisplatin-induced decrease of body weights in two mouse model. Cisplatin is the most widely used anticancer drug for treatment of various cancer. However, cisplatin treatment to cancer patients leads to many side effects such as nausea, vomiting and body weight decrease. BSTE has been used to decrease digestive disorders in South Korea. We hypothesize that BSTE improve the cisplatin-induced side effects in mouse models. We found that pre- and co-administration of BSTE inhibited decreases of body weights and food intake by cisplatin in mouse models. But BSTE had no synergistic effects for tumor shrinkage by cisplatin in xenograft model. Collectively, our data suggest that BSTE have great potential as a agent for having decrease effects on side effects by cisplatin in cancer patients.
Abstract
In this study, Banhasasim-tang extracts (BSTE) have an inhibitory effects on cisplatin-induced decrease of body weights in two mouse model. Cisplatin is the most widely used anticancer drug for treatment of various cancer. However, cisplatin treatment to cancer patients leads to many side effects such as nausea, vomiting and body weight decrease. BSTE has been used to decrease digestive disorders in South Korea. We hypothesize that BSTE improve the cisplatin-induced side effects in mouse models. We found that pre- and co-administration of BSTE inhibited decreases of body weights and food intake by cisplatin in mouse models. But BSTE had no synergistic effects for tumor shrinkage by cisplatin in xenograft model. Collectively, our data suggest that BSTE have great potential as a agent for having decrease effects on side effects by cisplatin in cancer patients.
참고문헌 (14)
- Pabla N, "Cisplatin nephrotoxicity : mechanisms and strategies", Kidney Int, 73, pp.994~1007 (2008)
- Kelland L., "The resurgence of platinum-based cancer chemotherapy", Nat Rev Cancer, 7, pp.573~584 (2007)
- Dasari S, "Cisplatin in cancer therapy : molecular mechanisms of action", Eur J Pharmacol, 740, pp.364~378 (2014)
- Zhang ZJ, "Shanghanzabinglun, Han dinasty, 200-210: hanhanlun", pp.112~ (1993), Daesungmunhwasa
- Heo, J., "Donguibogam", pp.397~ (2007), Namsandang
- 이광규, "半夏瀉心湯과 씨메티딘의 倂用投與가 흰쥐의 위궤양에 미치는 영향", 동의생리병리학회지, 16(3), pp.27~576 (2002), 한의병리학회
- Shin Mk, "Effect of Banhasasim-tang on the Cardiac Toxicity and clinical symptom induced by Doxorubicin", Korean J. Oriental Medical Prescription, 10(1), pp.131~142 (2002)
- Hwang HJ, "Effect of Banhasasim-tang on the Hepatic and Splenic Toxicity induced by Doxorubicin", J. of Kor. Oriental Oncology, 8(1), pp.9~21 (2002)
- Yoon SH. Ryu BH, "Evaluation for Therapeutic Effectiveness of Banwhasashim-tang in Functional Dyspepsia", Korean J. Orenta. Int. Med, 24(2), pp.329~336 (2003)
- Park JW, "The Effects of Banha-sasim-tang on dyspeptic symptoms and gastric motility in cases of functional dyspepsia: A randomized, double-blind, placebo-controlled, and two-center trial", Evid Based Complement Alternat Med, pp.265035~ (2013)
- Park JW, "Banha-sasim-tang as an herbal formula for the treatment of functional dyspepsia: a randomized, double-blind, placebo-controlled, two-center trial", Trials, 11, pp.83~ (2010)
- Aoyama T, "Double-blind, placebo-controlled, randomized phase II study of TJ-14(hangeshashinto)for gastric cancer chemotherapy-induced oral mucositis", Cancer Chemother Pharmacol, 73, pp.1047~1054 (2014)
- Yamashita T, "A traditional Japanese medicine--Hangeshashinto (TJ-14)--alleviates chemoradiation-induced mucositis and improves rates of treatment completion", Support. Care Cancer, 23, pp.29~35 (2015)
- 남궁정, "TC-1 세포주를 이용한 동물모델에서 As4O6에 의한 혈관폐쇄 효과", Obstetrics & Gynecology Science, 52(2), pp.220~227 (2009), 대한산부인과학회