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澤瀉散 抽出物이 Cisplatin으로 誘發된 흰쥐의 急性腎不全에 미치는 影響

Nephroprotective Effects of Taeksa-san Aqueous Extracts on Cisplatin-induced Rat Acute Renal Failure

강석봉|윤경민|장수영|이연경|유동조
대한한방내과학회 (The Society Of Korean Oriental Internal Medicine)|2009.12|대한한방내과학회지 (The Journal of Korean Oriental Internal Medicine)|제30권 제4호|pp. 832-844

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참고문헌

키워드

ARFAntioxidant effectCisplatinTaeksa-san(zexiesan)
주제분류한의학

초록

Objectives : This study is to observe the nephroprotective effects of the traditional prescription, Taeksa-san(TSS). The TSS has been generally used for treating various renal diseases, including renal failure. Methods : At first three different dosages of TSS extract were orally administered once a day for 28 days. At 23th day after TSS extract treatment, cisplatin has been treated. And then, 5 days after cisplatin treatment. all the rats (6 groups, each of 8 rats per group) were checked in the present study as follows. The changes on the body weight, kidney weight, serum BUN and creatinine levels were observed with changes on the kidney MDA and GSH contents. The results were compared with captopril 100mg/kg in which the effects on cisplatin-induced acute renal failures were already confirmed. Results : It showed dramatical decrease on the body weight, increase of the kidney weight, increase of serum BUN and creatinine levels were detected in cisplatin control as compared with intact control. In addition, marked increase of kidney MDA contents and decrease of kidney GSH contents were also detected in cisplatin control as compared with intact control. It means that cisplatin induced ARF are induced by oxidative stress and related lipid peroxidation in the present study. However, these ARFs and inhibition of antioxidant effects induced by cisplatin were dose-dependently reduced by treatment of all three different dosages of TSS extracts. Conclusion : This study suggest that TSS extracts showed favorable effects on the cisplatin-induced rat ARF.

Abstract

Objectives : This study is to observe the nephroprotective effects of the traditional prescription, Taeksa-san(TSS). The TSS has been generally used for treating various renal diseases, including renal failure. Methods : At first three different dosages of TSS extract were orally administered once a day for 28 days. At 23th day after TSS extract treatment, cisplatin has been treated. And then, 5 days after cisplatin treatment. all the rats (6 groups, each of 8 rats per group) were checked in the present study as follows. The changes on the body weight, kidney weight, serum BUN and creatinine levels were observed with changes on the kidney MDA and GSH contents. The results were compared with captopril 100mg/kg in which the effects on cisplatin-induced acute renal failures were already confirmed. Results : It showed dramatical decrease on the body weight, increase of the kidney weight, increase of serum BUN and creatinine levels were detected in cisplatin control as compared with intact control. In addition, marked increase of kidney MDA contents and decrease of kidney GSH contents were also detected in cisplatin control as compared with intact control. It means that cisplatin induced ARF are induced by oxidative stress and related lipid peroxidation in the present study. However, these ARFs and inhibition of antioxidant effects induced by cisplatin were dose-dependently reduced by treatment of all three different dosages of TSS extracts. Conclusion : This study suggest that TSS extracts showed favorable effects on the cisplatin-induced rat ARF.

참고문헌 (38)

  1. E. Braunwald, "Longo and J. Jameson. Harrion’s principles of internal medicine", pp.1794~1803 (2006), 도서출판 MIP
  2. 이천, "國譯 篇註 醫學入門 IV 雜病門", pp.700~ (1991), 남산당
  3. Lippman AJ, "Clinical trials of cis-diamminedichloroplatinum (NSC-119875)", Cancer Chemother Rep, 57, pp.191~200 (1973)
  4. Kavutcu M, "Reduced enzymatic antioxidant defense mechanism in kidney tissues from gentamicin-treated guinea pigs: effects of vitamins E and C", Nephron, 72, pp.269~274 (1996)
  5. Lowry OH, "Protein measurement with the Folin phenol reagent", J Biol Chem, 193, pp.265~275 (1951)
  6. Dahle LK, "The thiobarbituric acid reaction and the autoxidations of polyunsaturated fatty acid methyl esters", Arch Biochem Biophys, 193, pp.265~275 (1951)
  7. Eyer P, "Evaluation of the micromethod for determination of glutathione using enzymatic cycling and Ellman's reagent", Anal Biochem, 153, pp.57~66 (1986)
  8. Anderson RJ, "Prevention and management of acute renal failure", Hosp Prac, 28, pp.61~75 (1993)
  9. 김동현, "한방약리학", pp.49~53 (2006), 신일상사
  10. Safirstein R, "Cisplatin nephrotoxicity", Am J Kidney Dis, 8, pp.356~367 (1986)
  11. Salahudeen A, "Hydrogen peroxide induces 21-aminosteroid -inhibitable F2-isoprostane production and cytolysis in renal tubular epithelial cells", J Am Soc Nephrol, 6, pp.1300~1303 (1995)
  12. Masuda H, "Cisplatin generates superoxide anion by interaction with DNA in a cell-free system", Biochem Biophys Res Commun, 203, pp.1175~1180 (1994)
  13. Kuhlmann MK, "Insights into potential cellular mechanisms of cisplatin nephrotoxicity and their clinical application", Nephrol Dial Transplant, 12, pp.2478~2480 (1997)
  14. Cetin R, "Cisplatin impairs antioxidant system and causes oxidation in rat kidney tissues: possible protective roles of natural antioxidant foods", J Appl Toxicol, 26, pp.42~46 (2006)
  15. Ahn H, "Effect of glutathione and its related enzymes on chemosensitivity of renal cell carcinoma and bladder carcinoma cell lines", J Urol., 151, pp.263~267 (1994)
  16. Baldew GS, "Selective reduction of cisdiamminedichloropla-tinum(Ⅱ)", nephrotoxicity by ebselen Cancer Res, 50, pp.7031~7036 (1990)
  17. Kang DG, "Butein ameliorates renal concentrating ability in cisplatin-induced acute renal failure in rats", Biol Pharm Bull, 27, pp.366~370 (2004)
  18. Gordon JA, "Water metabolism after cisplatin in the rat", Am J Physiol, 243, pp.36~43 (1982)
  19. Seguro AC, "Renal concentration defect induced by cisplatin. The role of thick ascending limb and papillary collecting duct", Am J Nephrol, 9, pp.59~65 (1989)
  20. Suzuki CA, "The interactions of cis-diamminedichloroplatinum with metallothionein and glutathione in rat liver and kidney", Toxicology, 64, pp.113~127 (1990)
  21. Wong NL, "Mechanism of polyuria after cisplatin therapy", Nephron, 65, pp.623~627 (1993)
  22. Lieberthal W, "Mechanisms of death induced by cisplatin in proximal tubular epithelial cells: apoptosis vs. necrosis", Am J Physiol, 270, pp.700~708 (1996)
  23. Davis CA, "Manganese superoxide dismutase attenuates Cisplatin-induced renal injury: importance of superoxide", J Am Soc Nephrol, 12, pp.2683~2690 (2001)
  24. Karimi G, "Cisplatin nephrotoxicity and protection by milk thistle extract in rats", Evid Based Complement Alternat Med, 2, pp.383~386 (2005)
  25. Shimeda Y, "Protective effects of capsaicin against cisplatin-induced nephrotoxicity in rats", Biol Pharm Bull, 28, pp.1635~1638 (2005)
  26. Latha PG, "Chemoprotective effect of Ixora coccinea L. flowers on cisplatin induced toxicity in mice", Phytother Res, 15, pp.364~366 (2001)
  27. Duarte, C.G, "The effect of the antithyroid drug propylthiouracil on the alternative pathway of complement in rats", pp.22~ (2000), Int. J. Immunopharmacol
  28. Yu SJ, "-Ling, a Chinese herbal drug, modulates cytokine secretion by human peripheral blood monocytes", Int J Immunopharmacol, 18, pp.37~44 (1996)
  29. Mansour MA, "Protective effect of aminoguanidine against nephrotoxicity induced by cisplatin in normal rats", Comp Biochem Physiol C Toxicol Pharmacol, 132, pp.123~128 (2002)
  30. Sodikoff CH, "Laboratory profiles of small animal diseases. A guide to laboratory diagnosis. 2nd ed", pp.1~36 (1995), Mosby
  31. Kim YK, "Beneficial effect of pentoxifylline on cisplatin-induced acute renal failure in rabbits", Ren Fail, 25, pp.909~922 (2003)
  32. Gonzalez R, "Reversion by ozone treatment of acute nephrotoxicity induced by cisplatin in rats", Mediators Inflamm, 13, pp.307~312 (2004)
  33. Matsushima H, "The role of oxygen free radicals in cisplatin -induced acute renal failure in rats", J Lab Clin Med, 131, pp.518~526 (1998)
  34. Schinella GR, "Antioxidant activity of anti-inflammatory plant extracts", Life Sci, 70, pp.1023~1033 (2002)
  35. Joannidis M, "Medical therapy of acute kidney injury", pp.353~356 (2007), Acta Clin Belg Suppl
  36. Kuhad A, "Effect of curcumin on inflammation and oxidative stress in cisplatin-induced experimental nephrotoxicity", J Agric Food Chem, 55, pp.10150~10155 (2007)
  37. Yasukawa K, "3 beta-p- hydroxybenzoyldehydrotumulosic acid from Poria cocos, and its anti-inflammatory effect", Phytoche -mistry, 48, pp.1357~1360 (1998)
  38. Yamahara J, "Effects of crude drugs on congestive edema", Chem Pharm Bull (Tokyo)., 27, pp.1464~1468 (1979)

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