본문 바로가기
KERD
논문KCI 등재

Antidepressant effects of Cynanchum wilfordii Hemsley, Phlomis umbrosa Turcz, and Angelica gigas Nakai via Inhibition of 5-HT6 Receptor-mediated cyclic AMP Activity

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류한의학

초록

A This study evaluated the antidepressant effects of the herbal mixture CPAE(Cynanchum wilfordii Hemsley, Phlomis umbrosa Turcz, and Angelica gigas Nakai) using several tests, including a test for serotonin 6(5-HT6) receptor activity, the forced swimming test(FST), and tests for corticosterone(CORT) and monoamine levels. CPAE showed antagonistic effects on the 5-HT6 receptor in a stable 5-HT6 receptor–expressing cell line. We subsequently confirmed the antidepressant effects of CPAE in chronic stress model in mice and explored the underlying mechanisms of its action. Specifically, we observed that CPAE treatment significantly reduced immobility time in the FST and effectively restored abnormal levels of CORT in plasma and of monoamines(serotonin, dopamine, and norepinephrine) in hippocampus and prefrontal cortex. These results suggest that CPAE has significant antidepressant effects.

Abstract

A This study evaluated the antidepressant effects of the herbal mixture CPAE(Cynanchum wilfordii Hemsley, Phlomis umbrosa Turcz, and Angelica gigas Nakai) using several tests, including a test for serotonin 6(5-HT6) receptor activity, the forced swimming test(FST), and tests for corticosterone(CORT) and monoamine levels. CPAE showed antagonistic effects on the 5-HT6 receptor in a stable 5-HT6 receptor–expressing cell line. We subsequently confirmed the antidepressant effects of CPAE in chronic stress model in mice and explored the underlying mechanisms of its action. Specifically, we observed that CPAE treatment significantly reduced immobility time in the FST and effectively restored abnormal levels of CORT in plasma and of monoamines(serotonin, dopamine, and norepinephrine) in hippocampus and prefrontal cortex. These results suggest that CPAE has significant antidepressant effects.

참고문헌 (37)

  1. Nestler EJ, "Neurobiology of depression", Neuron, 34, pp.13~25 (2002)[DOI]
  2. AKupfer DJ, "Research in affective disorders comes of age", Am J Psychiatry, 156, pp.165~167 (1999)
  3. Lanni C, "Depression and antidepressants: molecular and cellular aspects", Cell Mol Life Sci, 66, pp.2985~3008 (2009)[DOI]
  4. Katz MM, "Drug-induced actions on brain neurotransmitter systems and changes in the behaviors and emotions of depressed patients", Neuropsychopharmacology, 11, pp.89~100 (1994)[DOI]
  5. Cleare AJ, "Pharmacological management of depressive disorders", Medicine, 44, pp.756~760 (2016)[DOI]
  6. Moller HJ, "Drug treatment of depression in the 1990s", Drugs, 52, pp.625~638 (1996)[DOI]
  7. Turner EH, "Selective publication of antidepressant trials and its influence on apparent efficacy", N Engl J Med, 358, pp.252~260 (2008)[DOI]
  8. Sodhi M, "Serotonin and brain development", Int Rev Neurobiol, 59, pp.111~174 (2004)
  9. Alcalde E, "Indene-Based Scaffolds. 2. An Indole- Indene Switch: Discovery of Novel Indenylsulfonamides as 5-<TEX>$HT_6$<", TEX> Serotonin Receptor Agonists, 2009, pp.52, 675~687
  10. Mitchell ES, "5-<TEX>$HT_6$<", TEX> receptors: a novel target for cognitive enhancement, 2005, pp.108, 320~333
  11. Millan MJ, "The neurobiology and control of anxious states", Prog Neurobiol, 70, pp.83~244 (2003)[DOI]
  12. Svenningsson P, "Biochemical and behavioral evidence for antidepressant-like effects of 5-<TEX>$HT_6$<", TEX> receptor stimulation, 2007, pp.27, 4201~4209
  13. Wesolowska A, "Effects of the brain-penetrant and selective 5-HT6 receptor antagonist SB-399885 in animal models of anxiety and depression", Neuropharmacology, 52, pp.1274~1283 (2007)[DOI]
  14. Hirano K, "Procognitive 5-HT6 antagonists in the rat forced swimming test: potential therapeutic utility in mood disorders associated with Alzheimer's disease", Life Sci, 84, pp.558~562 (2009)[DOI]
  15. Wesolowska A, "Anxiolytic-like and antidepressant-like effects produced by the selective 5-<TEX>$HT_6$<", TEX> receptor antagonist SB-258585 after intrahippocampal administration to rats, 2007, pp.18, 439~446
  16. Wesolowska A, "The selective 5-<TEX>$HT_6$<", TEX> receptor antagonist SB-399885 enhances anti-immobility action of antidepressants in rats, 2008, pp.582, 88~93
  17. 김선정, "백하수오와 자소엽 추출물의 생리활성 및 3T3-L1 전지방세포에 대한 분화 억제 효과", 한국식품영양과학회지, 45(5), pp.642~650 (2016), 한국식품영양과학회
  18. Yongfen Ma, "Anti-inflammatory Activities of Coumarins Isolated from Angelica gigas Nakai on LPS-stimulated RAW 264.7 Cells", Preventive Nutrition and Food Science, 14(3), pp.179~187 (2009), 한국식품영양과학회
  19. 김세종, "Evaluation of Estrogenic Activity of Extract from the Herbal Mixture Cynanchum wilfordii Hemsley, Phlomis umbrosa Turczaninow, and Angelica gigas Nakai", 한국독성학회지, 33(1), pp.71~77 (2017), 한국독성학회
  20. Chang A, "The Effect of Herbal Extract (EstroG-100) on Pre-, Peri-and Post-Menopausal Women: A Randomized Double-blind, Placebo-controlled Study", Phytother Res, 26, pp.510~516 (2012)[DOI]
  21. 김수남, "복합 생약추출물의 식물성 에스트로겐 활성이 OVX rat에 미치는 골대사 변화", 한국식품과학회지, 40(3), pp.316~320 (2008), 한국식품과학회
  22. Lee KH, "Evaluation of effectiveness and safety of natural plants extract (Estromon(R)) on perimenopausal women for 1 year", J Korean Soc Menopause, 11, pp.16~26 (2005)
  23. 배동혁, "Multifunctional antistress effects of standardized aqueous extracts from Hippophae rhamnoides L.", Animal Cells and Systems, 20(6), pp.369~383 (2016), 한국통합생물학회[DOI]
  24. Rosse G, "5-<TEX>$HT_6$<", TEX> receptor antagonists as potential therapeutics for cognitive impairment, 2010, pp.10, 207~221
  25. 이진우, "연자육의 항우울 효과 및 프로티옴 분석을 통한 기전 연구", 동의생리병리학회지, 20(4), pp.830~843 (2006), 한의병리학회
  26. Glavin GB, "Restraint stress in biomedical research: an update", Neurosci Biobehav Rev, 18, pp.223~249 (1994)[DOI]
  27. Gold PW, "New insights into the role of cortisol and the glucocorticoid receptor in severe depression", Biol Psychiatry, 52, pp.381~385 (2002)[DOI]
  28. Kalynchuk LE, "Corticosterone increases depression-like behavior, with some effects on predator odor-induced defensive behavior, in male and female rats", Behav Neurosci, 118, pp.1365~ (2004)[DOI]
  29. Johnson SA, "Effect of different doses of corticosterone on depression-like behavior and HPA axis responses to a novel stressor", Behav Brain Res, 168, pp.280~288 (2006)[DOI]
  30. Murray F, "Chronic low dose corticosterone exposure decreased hippocampal cell proliferation, volume and induced anxiety and depression like behaviours in mice", Eur J Pharmacol, 583, pp.115~127 (2008)[DOI]
  31. O'mahony CM, "Strain differences in the neurochemical response to chronic restraint stress in the rat: relevance to depression", Pharmacol Biochem Behav, 97, pp.690~699 (2011)[DOI]
  32. Dang H, "Antidepressant effects of ginseng total saponins in the forced swimming test and chronic mild stress models of depression", Prog Neuro-Psychopharmacol Biol Psychiatry, 33, pp.1417~1424 (2009)[DOI]
  33. Yu Y, "Antidepressant-like effect of trans-resveratrol in chronic stress model: behavioral and neurochemical evidences", J Psychiatr Res, 47, pp.315~322 (2013)[DOI]
  34. Lacroix LP, "5-HT6 receptor antagonist SB-271046 enhances extracellular levels of monoamines in the rat medial prefrontal cortex", Synapse, 51, pp.158~164 (2004)[DOI]
  35. Dawson LA, "Potentiation of amphetamine-induced changes in dopamine and 5-HT by a 5-<TEX>$HT_6$<", TEX> receptor antagonist, 2003, pp.59, 513~521
  36. "Correlation between stress and biological indicators", Epidemiology and health (2003)
  37. 나주련, "Antistress Effects of Rosa rugosa Thunb. on Total Sleep Deprivation–Induced Anxiety-Like Behavior and Cognitive Dysfunction in Rat: Possible Mechanism of Action of 5-HT6 Receptor Antagonist", Journal of Medicinal Food, 19(9), pp.870~881 (2016), 한국식품영양과학회[DOI]

관련 논문AI추천

이 간행물의 다른 논문 (12건)