Antidepressant-like and Hypnotic Effects of the Herbal Extract Combination of Stauntonia hexaphylla and Vaccinium bracteatum Fruit in Mice
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Stauntonia hexaphylla (SH) and Vaccinium bracteatum (VB) are herbal extracts widely used in food and traditional herbal medicine, and have the ability to perform a wide range of biological activities. We aimed to investigate the effects of the SH and VB combination (SHVB) on mice models of chronic restraint stress (CRS) and pentobarbital-induced sleeping behaviors to elucidate its possible mechanisms of action. CRS-exposed mice treated with SHVB showed significantly decreased immobility time, increased swimming and climbing times in the forced swim test (FST), and increased locomotor activity in the open field test (OFT). SHVB decreased serum CORT levels, but enhanced brain monoamine neurotransmitters. SHVB significantly decreased the sleep latency and increased total sleep duration in pentobarbital-induced sleeping behavior in mice. SHVB showed inhibitory effect on 5-HT2A receptor-mediated ERK1/2 phosphorylation. These results suggest that SHVB has antidepressant and hypnotic effects by regulating the 5-HT2A receptor.
Abstract
Stauntonia hexaphylla (SH) and Vaccinium bracteatum (VB) are herbal extracts widely used in food and traditional herbal medicine, and have the ability to perform a wide range of biological activities. We aimed to investigate the effects of the SH and VB combination (SHVB) on mice models of chronic restraint stress (CRS) and pentobarbital-induced sleeping behaviors to elucidate its possible mechanisms of action. CRS-exposed mice treated with SHVB showed significantly decreased immobility time, increased swimming and climbing times in the forced swim test (FST), and increased locomotor activity in the open field test (OFT). SHVB decreased serum CORT levels, but enhanced brain monoamine neurotransmitters. SHVB significantly decreased the sleep latency and increased total sleep duration in pentobarbital-induced sleeping behavior in mice. SHVB showed inhibitory effect on 5-HT2A receptor-mediated ERK1/2 phosphorylation. These results suggest that SHVB has antidepressant and hypnotic effects by regulating the 5-HT2A receptor.
참고문헌 (35)
- Nutt D, "Sleep disorders as core symptoms of depression", Dialogues Clin Neurosci, 10(3), pp.329~336 (2008)
- American Psychiatric Association, "Diagnostic and statistical manual of mental disorders" (2013)
- Wichniak A, "Sleep and antidepressant treatment", Curr Pharm Des, 18(36), pp.5802~5817 (2012)
- Chiba S, "Chronic restraint stress causes anxiety-and depression-like behaviors, downregulates glucocorticoid receptor expression, and attenuates glutamate release induced by brain-derived neurotrophic factor in the prefrontal cortex", Prog Neuro-psychopharmacol, 39(1), pp.112~119 (2012)
- Mahar I, "Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects", Neurosci Biobehav Rev, 38, pp.173~192 (2014)
- Vanover KE, "Role of 5-HT2A receptor antagonists in the treatment of insomnia", Nat Sci Sleep, 2, pp.139~150 (2010)
- Ikuta A, "Biotechnology in Agriculture and Forestry Vol 24", pp.352~360 (1993)
- 박윤점, "멀꿀의 화학성분과 생리활성", 한국자원식물학회지, 22(5), pp.403~411 (2009), 한국자원식물학회
- Wang HB, "A phenolic glycoside and triterpenoids from Stauntonia hexaphylla", Phytochemistry, 47, pp.467~470 (1998)
- Hwang SH, "Inhibitory activities of Stauntonia hexaphylla leaf constituents on rat lens aldose reductase and formation of advanced lycation end products and antioxidant", BioMed Res International, 2017, pp.4273257~ (2017)
- Cheon YH, "Stauntonia hexaphylla(Lardizabalaceae)leaf methanol extract inhibits osteoclastogenesis and bone resorption activity via proteasome-mediated degradation of c-Fos protein and suppression of NFATc1 expression", BMC Complement Altern Med, 15, pp.280~ (2015)
- Kim J, "Anti-inflammatory effects of a Stauntonia hexaphylla fruit Extract in lipopolysaccharide-activated RAW-264.7 macrophages and rats by carrageenan-induced hind paw swelling", Nutrients, 10(1) (2018)
- 이규옥, "멀꿀 열매 추출물의 항산화 활성 및 H2O2로 유도된 산화적 스트레스와 아세트아미노펜 독성 모델에서의 간 보호효과", 생명과학회지, 28(6), pp.708~717 (2018), 한국생명과학회[DOI]
- Hwang SH, "Inhibitory activities of Stauntonia hexaphylla leaf constituents on rat lens aldose reductase and formation of advanced glycation end products and antioxidant", BioMed Res International, 2017, pp.4273257~ (2017)
- Wang L, "Study on the extraction of black pigment from Vaccinium bracteatumThunb. leaves by enzyme and its stability", Sci Technol Food Industry, 29, pp.224~226 (2008)
- Hu J, "Phytochemical compositions, antioxidant and antimicrobial activities analysis of extracts from Vaccinium bracteatum Thunb. leaves", J App Bot Food Qual, 89, pp.150~155 (2016)
- Wang L, "Effect of Vaccinium bracteatumThunb. leaves extract on blood glucose and plasma lipid levels in streptozotocin-induced diabetic mice", J Ethnopharmacol, 130, pp.465~469 (2010)
- Wang L, "Antidiabetic activity of Vaccinium bracteatum Thunb. leaves’ polysaccharide in STZ-induced diabetic mice", Int J Biol Macromol, 61, pp.317~321 (2013)
- Zhang J, "Isolation and identification of antioxidant compounds in Vaccinium bracteatum Thunb. by UHPLC-Q-TOF LC", MS and their kidney damage protection, 2014, pp.11, 62~70
- Wang L, "The protective effect of Vaccinium bracteatum Thunb. leaves and the extract against light injury of retina", J Xi'an Jiaotong Uni, 27, pp.284~287 (2006)
- 권승환, "Vaccinium bracteatum Thunb. Exerts Anti-Inflammatory Activity by Inhibiting NF-κB Activation in BV-2 Microglial Cells", Biomolecules & Therapeutics, 24(5), pp.543~551 (2016), 한국응용약물학회
- Landa P, "In vitro antiproliferative and anti-inflammatory activity of leaf and fruit extracts from Vaccinium bracteatum Thunb", Pak J Pharm Sci, 27, pp.103~106 (2014)
- Oh DR, "Antidepressant-Like Effects of Vaccinium bracteatum in Chronic Restraint Stress Mice : Functional Actions and Mechanism Explorations", Am J Chin Med, 46(2), pp.357~387 (2018)
- Oh DR, "Antidepressant effects of Vaccinium bracteatum via protection against hydrogen peroxide-induced oxidative stress and apoptosis", Am J Chin Med, 4, pp.1~20 (2018)
- Oh DR, "through the regulation of serotonegic and GABAA-ergic systems : involvement of 5-HT1A receptor agonistic activity", Biomed Pharmacother, 109, pp.2218~2227 (2019)
- Moreau M, "Inoculation of Bacillus Calmette-Guerin to mice induces an acute episode of sickness behavior followed by chronic depressive-like behavior", Brain Behav Imm, 22(7), pp.1087~1095 (2008)
- Abelaira H, "Animal models as tools to study the pathophysiology of depression", Braz J Psychiatry, 35(2), pp.S112~20 (2013)
- Mah L, "Can anxiety damage the brain?", Curr Opin Psychiatry, 29, pp.56~63 (2016)
- Tafet GE, "Correlation between cortisol level and serotonin uptake in patients with chronic stress and depression", Cogn Affect Behav Neurosci, 1(4), pp.388~393 (2001)
- Siegel AM, "Diagnosis and Treatment of Anxiety in the Aging Woman", Curr psychiatry Rep, 17(12), pp.93~ (2015)
- Walf AA, "A review and update of mechanisms of estrogen in the hippocampus and amygdala for anxiety and depression behavior", Neuropsychopharmacology, 31(6), pp.1097~1111 (2006)
- Nollet M, "REM sleep's unique associations with corticosterone regulation, apoptotic pathways, and behavior in chronic stress in mice", Proc Nat Acad Sci. U S A, 116(7), pp.2733~2742 (2019)
- Trajkovska V, "Activation of glucocorticoid receptors increases 5-HT2A receptor levels", Exp Neurol, 218(1), pp.83~91 (2009)
- Santos Moraes WA, "Sedative antidepressants and insomnia", Braz J Psychiatry, 33(1), pp.91~95 (2011)
- Shrivastava M, "Therapeutic potential of Hypericum perforatum : a review", Int J Res Pharm Sci, 6(12), pp.4982~4988 (2015)
