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한약의 항우울 효과에 대한 국내 실험연구 고찰

A Review of the Korean Experimental Studies on the Antidepressant Effect of Herbal Medicines

김상호|정대규|한다영
대한한방신경정신과학회 (The Korean Society Of Oriental Neuropsychiatry)|2019.06|동의신경정신과학회지 (The Korean Society of Oriental Neuropsychiatry)|제30권 제2호|pp. 71-88|DOI 10.7231/jon.2019.30.2.071

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참고문헌

키워드

DepressionHerbal medicineReview.Depressive disorderAntidepressant
주제분류한의학

초록

Objectives: The present study aims to review the antidepressant effect of herbal medicines reported in Korean local journals.Methods: We searched in electronic databases (Koreantk, KISS, OASIS, NDSL) for studies, published in Korean national journals, that assessed herbal medicine effect of depression model. The search term was ‘depression’ in the abstract or whole text. Depression model, herbal material, experimental results, mechanisms were extracted.Results: We included 43 articles in which 38 studies were in vitro experiments, and the rest 5 were in vivo experiments. The most common experiment subject model was a rat and the most widely used method to induce depression was Despair behavior test. 21 studies used simple herbal medicines, and 22 studies used complex herbal medication. Glycyrrhizae Radix was the most commonly used herbal material to improve depression model. The most common mechanisms of herbal medicine with anti-depressant effect were inhibition of Monoamine activation mechanism and depression related neuro-hormone secretion.Conclusions: Herbal medicines may be a promising resource for treating depression.

Abstract

Objectives: The present study aims to review the antidepressant effect of herbal medicines reported in Korean local journals.Methods: We searched in electronic databases (Koreantk, KISS, OASIS, NDSL) for studies, published in Korean national journals, that assessed herbal medicine effect of depression model. The search term was ‘depression’ in the abstract or whole text. Depression model, herbal material, experimental results, mechanisms were extracted.Results: We included 43 articles in which 38 studies were in vitro experiments, and the rest 5 were in vivo experiments. The most common experiment subject model was a rat and the most widely used method to induce depression was Despair behavior test. 21 studies used simple herbal medicines, and 22 studies used complex herbal medication. Glycyrrhizae Radix was the most commonly used herbal material to improve depression model. The most common mechanisms of herbal medicine with anti-depressant effect were inhibition of Monoamine activation mechanism and depression related neuro-hormone secretion.Conclusions: Herbal medicines may be a promising resource for treating depression.

참고문헌 (107)

  1. Min SG, "Modern Psychiatry", pp.321~329 (2015), Ilchokak
  2. Depression and Other Common Mental Disorders-Global Helath Estimates, "WHO", World Health Organization, ~ (2017)
  3. The 2016 Epidemiological Survey of Mental Disorders Among Korean Adults, "Hong JP", Seoul National University College of Medicine, ~ (2016)
  4. Sapin C., "Usefulness of EQ-5D in Assessing Health Status in Primary Care", Health and Quality of Life Outcomes, 2(1), pp.1~8 (2004)
  5. Stewart WF, "Cost of Lost Productive Work Time Among US Workers with Depression", JAMA, 289, pp.3135~3144 (2003)
  6. Egede LE, "Impact of diagnosed depression on healthcare costs in adults with and without diabetes: United States, 2004-2011", J Affect Disord, 195, pp.119~126 (2016)
  7. World Health Organization, "Pharmacological Treatment of Mental Disorders in Primary Health Care" (2009), World Health Organization
  8. Korean Society for Affective Disorders, "Text book of de-pressive disorders", pp.53~65 (2012), Sigmapress
  9. Uher R, "Early and delayed onset of re-sponse to antidepressants in individual trajectories of change during treatment of major depression: a secon-dary analysis of data from the Genome-Based Therapeutic Drugs for Depression (GENDEP) study", J Clin Psychiatry, 72, pp.1478~1484 (2011)
  10. Mrazek DA, "A review of the clinical, economic, and societal burden of treat-ment-resistant depression: 1996-2013", Psychiatr Serv, 65, pp.977~987 (2014)
  11. The Korean Neuropsychiatric Association, "Textbook of neuropsychiatry", pp.164~180 (2005), Jungang Publisher
  12. Oh HM, "A comparative study on physiopathology of depression by Korean medicine and conventional medicine", Journal of Haehwa Medicine, 26(1), pp.11~18 (2017)
  13. Ahmed HM, "Ethnomedicinal, Phytochemical and Pharmacological Investigations of Perilla frutescens (L.)Britt", Molecules, 24(1), pp.1~23 (2018)
  14. Yuan QJ, "Effects of Xingpi Kaiyu Fang on ATP, Na", K-ATPase, and Respiratory Chain Complexes of Hippocampus and Gastrocnemius Muscle in Depressed Rats, 2019, pp.2019, 1~12
  15. Adeoluwa AO, "Butanol Fraction of Olax Subscorpioi-dea Produces Antidepressant Effect: Evidence for the Involvement of Monoaminergic Neurotransmission", Drug Res (Stuttg), 69(1), pp.53~60 (2019)
  16. Farahani MS, "Plant-derived Natural Medicines for the Management of Depression: an Overview of Mechanisms of Action", Reviews in the Neurosciences, 26(3), pp.1~17 (2015)
  17. Hirshler Y, "Neuroplasticity-related Mechanisms Underlying the Antidepressant-like Effects of Traditional Herbal Medicines", European Neuropsychopharmacology, 27(10), pp.945~958 (2017)
  18. Lee JH, "The Effects of Koamsimsinwhan(without Cinnabarite) on Depression in Chronic Mild Stress(CMS)-treated Rats", J. of Oriental Neuropsychiatry, 13(2), pp.107~119 (2002)
  19. Cho CH, "Effects of Chengwhabosimtang on Depression, Anxiety, TH and c-Fos of the Brain in the Model Rats", J. of Oriental Neuropsychiatry, 14(2), pp.61~78 (2003)
  20. Chung SY, "Effects of Hwangryeonhaedoktang on Depression and c-Fos Expression in Paraventricular Nucleus of the Brain in the Chronic Mild Stress Treated Rats", J. of Oriental Neuropsychiatry, 14(1), pp.1~16 (2003)
  21. 홍성유, "The effect of Bupleurum falcatum L. on the catecholamines of depression rat model", 대한본초학회지, 18(4), pp.27~253 (2003), 대한본초학회
  22. Hong SW, "The Effects of Hwangryeonhae-doktang on Morris Water Maze and Tyrosine Hydroxylase Expression in Ventral Tegmental Area Locus Coeruleus of the Chronic Mild Stress Animal Model of Depression", J. of Oriental Neuropsychiatry, 14(1), pp.27~44 (2003)
  23. 김경호, "Effects of Radix Polygalae Extract on Sociopsychological Stress", 대한본초학회지, 18(1), pp.12~108 (2003), 대한본초학회
  24. Lee DK, "Antidepressant Effect of Licium Chninense Mill. and Its Influence on Influence on Indoleamine and Ios Metabolite of Depression Model Rat", The Korean Journal of Medical Prescription, 11(2), pp.185~196 (2003)
  25. 이한창, "구속 스트레스 (immobilization stress)를 가한 rat의 hypothalamus에서의 유전자 발현 및 補心建脾湯의 항스트레스 효과에 관한 cDNA microarray 분석", 동의생리병리학회지, 17(6), pp.1393~1403 (2003), 한의병리학회
  26. Kim KO, "The Effects of Jowiseuncheongtang Versus St. John’s Wort in the Chronic Mild Stress Model of Depression in Rats", J. of Oriental Neuropsychiatry, 15(1), pp.43~64 (2004)
  27. Kim IJ, "Experimental Study on the Antide-pressant Effect og Ginseng Radix Alba and Cyperi Rhizoma", J. of Oriental Neuropsychiatry, 15(1), pp.101~119 (2004)
  28. Park JH, "Antidepressant Effect of Chungwangboshimdan and Its Influence on Monoamines", The Korean J. of oriental Medical Prescription, 12(2), pp.77~93 (2004)
  29. 신화석, "四逆散의 抗憂鬱效果 및 腦內 monoamine에 미치는 영향", 대한본초학회지, 19(2), pp.71~82 (2004), 대한본초학회
  30. 원호영, "Effects of Nodus Nelumbinis Rhizomatis extracts on Sociopsychological Stress in Mice", 동의신경정신과학회지, 15(2), pp.149~158 (2004), 대한한방신경정신과학회
  31. 이태희, "구속 스트레스로 유발된 기억 손상에 대한 麥門冬의 신경보호 효능", 대한본초학회지, 21(2), pp.63~75 (2006), 대한본초학회
  32. 이진우, "연자육의 항우울 효과 및 프로티옴 분석을 통한 기전 연구", 동의생리병리학회지, 20(4), pp.830~843 (2006), 한의병리학회
  33. 심인섭, "Anti-depressant Effect of Chilbokum Under The Forced Swimming Test in Rats", 대한한의학회지, 27(4), pp.192~198 (2006), 대한한의학회
  34. 조용국, "柴胡抑肝湯이 스트레스로 인한 기억저하와 우울행동에 미치는 영향", 대한한의학 방제학회지, 15(2), pp.147~160 (2007), 대한한의학방제학회
  35. 정민호, "柴胡疏肝散이 스트레스로 인한 기억저하와 우울행동에 미치는 영향", 대한본초학회지, 22(2), pp.127~135 (2007), 대한본초학회
  36. 이재열, "鬱金의 항우울 효과에 대한 실험적 연구", 동의신경정신과학회지, 18(2), pp.45~55 (2007), 대한한방신경정신과학회
  37. 박진석, "淸心溫膽湯의 항우울 효과에 대한 실험적 연구", 동의신경정신과학회지, 18(1), pp.1~14 (2007), 대한한방신경정신과학회
  38. 이상택, "三精丸의 항우울 효과에 대한 실험적 연구", 동의신경정신과학회지, 19(3), pp.101~116 (2008), 대한한방신경정신과학회
  39. 이승엽, "소양인 형방도적산과 양격산화탕의 항 스트레스효과에 관한 실험적 연구", 사상체질의학회지, 20(3), pp.151~163 (2008), 사상체질의학회
  40. 장문규, "附子의 우울증 억제효과에 관한 연구", 동의신경정신과학회지, 20(3), pp.49~64 (2009), 대한한방신경정신과학회
  41. 박수현, "청피가 FST에서 TH와 ACTH변화에 미치는 영향", 대한본초학회지, 24(1), pp.141~150 (2009), 대한본초학회
  42. 박찬혁, "梔子가 강제수영부하시험에서 Corticotropin-Releasing Factor, c-fos와 Tyrosine Hydroxylase에 미치는 영향", 대한한의학 방제학회지, 17(1), pp.163~173 (2009), 대한한의학방제학회
  43. 성영석, "牧丹皮가 강제수영부하시험에서 Corticotropin-Releasing Factor, c-Fos 와 Tyrosine Hydroxylase에 미치는 영향", 대한한의학 방제학회지, 17(1), pp.129~140 (2009), 대한한의학방제학회
  44. 김효준, "連翹가 강제수영부하시험에서 CRF, c-Fos와 TH에 미치는 영향", 대한한의학 방제학회지, 18(1), pp.155~167 (2010), 대한한의학방제학회
  45. 민남기, "赤芍藥이 강제수영부하시험에서 CRF, c-Fos 와 TH에 미치는 영향", 대한본초학회지, 25(4), pp.61~67 (2010), 대한본초학회
  46. 노동진, "加味歸脾湯이 P815 세포의 serotonin 대사 과정에 미치는 영향", 동의신경정신과학회지, 21(1), pp.1~11 (2010), 대한한방신경정신과학회
  47. 박현정, "Neural Mechanisms Underlying Antidepressant-Like Effects of Glycyrrhizae Radix in Rats", 동의생리병리학회지, 24(6), pp.1053~1058 (2010), 한의병리학회
  48. 박재범, "生地黃이 강제수영부하시험에서 HPA Axis System과 Catecholaminergic System에 미치는 영향", 대한한의학 방제학회지, 18(1), pp.133~144 (2010), 대한한의학방제학회
  49. 임재원, "分心氣飮加味方의 항산화능과 serotonin 대사에 미치는 영향", 동의신경정신과학회지, 22(2), pp.147~162 (2011), 대한한방신경정신과학회
  50. 심태경, "加味逍遙散의 항산화 효과와 serotonin 대사과정에 미치는 영향", 동의신경정신과학회지, 22(1), pp.37~51 (2011), 대한한방신경정신과학회
  51. 황지연, "小烏沈湯加減方의 산화스트레스와 serotonin 대사 과정에 미치는 영향", 동의생리병리학회지, 27(4), pp.422~430 (2013), 한의병리학회
  52. 유윤선, "구속스트레스로 불안과 우울증상을 일으킨 백서에서 죽여의 개선 효과", 동의신경정신과학회지, 24(3), pp.293~308 (2013), 대한한방신경정신과학회
  53. 설선희, "溫膽湯加味方의 항산화와 Serotonin 대사 과정에 미치는 영향", 동의신경정신과학회지, 24(2), pp.189~200 (2013), 대한한방신경정신과학회
  54. 유주연, "후박의 항우울 효과에 대한 실험적 연구", 대한한방내과학회지, 34(3), pp.256~266 (2013), 대한한방내과학회
  55. 강민구, "만성스트레스 모델에서 하엽추출물의 항우울 효과", 대한본초학회지, 29(2), pp.7~13 (2014), 대한본초학회
  56. 김국기, "우울증 생쥐 모델에서 半夏厚朴湯加味의 항우울 효과", 동의신경정신과학회지, 25(2), pp.191~202 (2014), 대한한방신경정신과학회
  57. 고성렬, "LPS로 유발된 우울증에 대한 甘草의 효과", 대한본초학회지, 29(5), pp.9~16 (2014), 대한본초학회
  58. 이은희, "우울증 유발 생쥐에서 溫膽湯加烏藥의 항우울 효과", 동의생리병리학회지, 28(4), pp.403~410 (2014), 한의병리학회
  59. 구필성, "BDNF, ERK 및 CREB 경로를 통한 포공영 추출물의 항우울 효과", 대한본초학회지, 30(3), pp.13~17 (2015), 대한본초학회
  60. 이원행, "柴胡와 酸漿 복합제가 LPS로 유도된 우울증에 미치는 효과", 대한본초학회지, 30(3), pp.69~76 (2015), 대한본초학회
  61. American Psychiatric Association, "Diagnostic and Statistical Manual of Mental Disorders", pp.163~ (2015), Hakjisa
  62. Delgado PL, "Depression: The Case for a Monoamine Deficiency", The Journal of Clinical Psychiatry, 61, pp.7~11 (2000)
  63. Femina PV, "The Hypothalamic-Pituitary-Adrenal Axis in Major Depressive Disorder: A Brief Primer for Primary Care Physicians", Prim Care Companion to The Journal of Clinical Psychiatry, 3(4), pp.151~155 (2001)
  64. Smith RS, "The Macrophage Theory of Depression", Med Hypotheses, 35(4), pp.298~306 (1991)
  65. Liu L, "Herbal Medicine for Anxiety, Depression and Insomnia", Curr Neuro-pharmacol, 13(4), pp.481~493 (2015)
  66. Maruyama Y., "Identification of Magnolol and Honokiol as Anxiolytic Agents in Extracts of Saiboku-to, an Oriental Herbal Medicine", J. Nat. Prod, 61(1), pp.135~138 (1998)
  67. Gao X, "Metabonomic Study on Chronic Unpredictable Mild Stress and Intervention Effects of Xiaoyaosan in Rats Using Gas Chromatography Coupled with Mass Spectrometry", J. Ethnopharmacol, 137(1), pp.690~699 (2011)
  68. Peng X., "Study on the BDNF", CREB Signal Mechanism of Antidepressant Effect of Xiaoyao Powder, 2012, pp.28, 9~12
  69. Jia G. C., "Effects of Xiaoyaosan on Chronic Unpredictable Mild Stress Model in Rats", Chinese J. Exper. Trad. Med. Formulae, 17, pp.150~154 (2011)
  70. Ryu JM, "The Effects of Jowiseuncheongtang Versus Fluoxetine in the Chronic Mild Stress Model of Depression in Rats", J. of Oriental Neuropsychiatry, 15(1), pp.27~41 (2004)
  71. McGuirk J, "Effects of Chronically Administered Fluoxetine and Fenfluramine on Food Intake, Body weight and the Behavioral Satiety Sequence", Psychopharmacology, 106(3), pp.401~407 (1992)
  72. Marona LD, "The Effect of Selective Serotonin Releasing Agents in the Chronic Mild Stress Model of Depression in Rats", Stress, 2(2), pp.91~100 (1997)
  73. Schindler R, "Culture of neoplastic mast cells and their synthesis of 5-hydroxytryptamine and histamine in vitro", Cancer Res, 19(1), pp.47~51 (1959)
  74. Wang QZ, "The Recent Progress in Animal Models of Depression", Progress in Neuropsychopharmacology & Biological Psychiatry, 77, pp.99~109 (2017)
  75. Steru L., "The Tail Suspension Test: a New Method for Screening Antidepressants in Mice", Psychopharmacology, 85(3), pp.367~370 (1985)
  76. Muscat R, "Reversal of Stress-in-duced Anhedonia by the Atypical Antidepressants, Fluoxetine and Maprotiline", Psychopharmacology, 109(4), pp.433~438 (1992)
  77. The Textbook Compilation Committee of Herbalogy of Oriental Medical Schools in Nation, "Herbalogy", pp.186~188 (2008), Younglim Publisher
  78. The Compilation Committee of Pharmacology of Oriental Medicine, "Pharmacology of Oriental Medicine", pp.135~141 (2015), Shinilbooks
  79. Ingvardsen BK, "Possible mechanism of c-Fos expression in trigeminal nucleus caudalis following cortical spreading depression", 72(3), pp.407~415 (1997)
  80. Jacob MD, "Structure of an IκB", NFκB complex, 1998, pp.95(6), 749~758
  81. Kim DS, "A novel mechanism for constitutive NF-κB ac-tivation: I-κBa depletion by transglutaminase 2 and mu-calpain occurs in parallel with the ubiquitin-proteasome pathway", pp.2011
  82. Robert Ader, "Psychoneuroimmunology", pp.50~54 (2007), Elsevier
  83. Fujioka S, "NF-κB and AP-1 Connection: Mechanism of NF-κB-Dependent Regulation of AP-1 Activity", Mol Cell Biol, 24(17), pp.7806~7819 (2004)
  84. Shin CG, "Catechetical herbology", pp.193~ (1992), Sungbosa
  85. Kang HW, "A Study on the Oriental-medical Understanding of Depression", J. of Oreintal Neuropsychiatry, 12(2), pp.1~15 (2001)
  86. Bogdanski DF., "The Distribution of Serotonin, 5‐hydroxytryptophan Decar-boxylase, and Monoamine Oxidase in Brain", Journal of Neurochemistry, 1(3), pp.272~278 (1957)
  87. 이재은, "우울증에 대한 한약물 치료 문헌적 고찰 - 무작위 대조군 임상연구를 중심으로 -", 동의신경정신과학회지, 22(4), pp.31~40 (2011), 대한한방신경정신과학회
  88. 우정아, "우울증 치료의 중의학 최신 임상연구 동향 -무작위 대조군 임상연구와 체계적 문헌 고찰을 중심으로-", 동의생리병리학회지, 29(6), pp.458~466 (2015), 한의병리학회[DOI]
  89. Lee B, "Effect od Bupleurum Falcatum on the Stress-induced Impairment of Spatial Working Memory in Rats", Biol Pharm Bull, 32(8), pp.1392~1398 (2009)
  90. 이봄비, "Bupleurum falcatum Prevents Depression and Anxiety-Like Behaviors in Rats Exposed to Repeated Restraint Stress", Journal of Microbiology and Biotechnology, 22(3), pp.422~430 (2012), 한국미생물·생명공학회
  91. Kwon SO, "Antidepressant-like effect of the methanolic extract from Bupleurum fal-catum in the tail suspension test", Prog Neuro-psychoph, 34(2), pp.265~270 (2009)
  92. Kang HW, "A Study on The Oriental-medical Understanding of Depression", Journal of Oriental Neuropsychiatry, 12(2), pp.1~15 (2001)
  93. Lovenberg, W., "Tryptophan Hydroxylation; Measurement in Pineal Gland, Brain Stem and Carcinoid Tumor", Science, 155, pp.217~219 (1967)
  94. Blakely, R. D., "Molecular Physiology of Norepinephrine and Serotonin Transporters", The Journal of Experimental Biology, 196, pp.263~281 (1994)
  95. Cannon WB, "The wisdom of the body", pp.19~40 (1963), Norton and Company Inc
  96. Whang WW, "Psychosomatic", pp.21~27 (1985), Henglim Publishing Co
  97. D’Sa C, "Antidepressants and neuroplasticity", Bipolar Disord, 4, pp.183~194 (2002)
  98. Pittenger C, "Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms", Neuropsychopharmacology, 33, pp.88~109 (2008)
  99. Mesulam MM, "Neuroplasticity Failure in Alzheimer’s Disease : Bridging the gap between plaques and tangles", Neuron, 24, pp.521~529 (1999)
  100. Lv XF, "NAc Shell Arc", Arg3.1Protein Mediates Reconsolidation of Morphine CPP by Increased GluR1 Cell Surface Expression: Activation of ERK-Coupled CREB is Required, 2015, pp.18(9), 1~10
  101. Wan L, "RACK1 af-fects morphine reward via BDNF", Brain Res, 1416, pp.26~34 (2011)
  102. Takano K, "Imipramine induces brain-derived neuro-trophic factor mRNA expression in cultured astrocytes", J Pharmacol Sci, 120(3), pp.176~186 (2012)
  103. Duman RS, "Role of neurotrophic factors in the etiology and treatment of mood disorders", Neuromolecular Med, 5, pp.11~25 (2004)
  104. Alt A, "AMPA receptor potentia-tors as novel antidepressants", Curr Pharm Des, 11, pp.1511~1527 (2005)
  105. Kang SS, "Baleun Bangjehag", pp.128~ (1996), Daeseong munh-wasa
  106. Ju, Y.S, "Ungok Herbology", pp.827~ (2013), Woosuk Press
  107. Butterweck V, "Long-term dffects of St. John’s wort and hypericin in monoamine levels in rat hypothalamus and hipocampus", Brain Res, 930(1-2), pp.21~29 (2002)

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