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靈神草의 항우울 효과에 대한 행동약리학적 연구

Studies on the Behavioral Pharmacology of the Antidepressant Effect of Polygala japonica Houtt

정대규|이은경
대한한방신경정신과학회 (The Korean Society Of Oriental Neuropsychiatry)|2011.06|동의신경정신과학회지 (The Korean Society of Oriental Neuropsychiatry)|제22권 제2호|pp. 129-146

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키워드

AntidepressantAnxiolyticPolygala japonicaElevated plus-mazeForced swimming test
주제분류한의학

초록

Objectives :The purpose of this study was to characterize the putative antidepressant and antianxiolytic effects of the 70% ethanol extract of Polygala japonica(EEPJ) using animal's behavioral experiment in mice. Methods :The effect of EEPJ on the anxioty and depressive disorder was investigated via mice's behavioral experiment like Elevated plus-maze, Horizontal wire test, Open field test, Forced swimming test, Tail suspension test, and it was happen via any mechanism by WAY 100635, a 5-HT1A receptor antagonist and by Flumazenil, a GABAA antagonist Results :1. In the EPM, single treatments of the EEPJ(200 and 400㎎/㎏) had usefully antianxiolytic effects versus vehicle, which was medicated via the serotonergic nervous system. 2. In the HWT, single treatments of the EEPJ were no changes in the myorelaxant effects versus vehicle. 3. In the OFT, single treatments of the EEPJ were no changes in the locomotor activity versus vehicle. 4. In the FST, single treatments of the EEPJ(50㎎/㎏) significantly reduced the immobility time versus vehicle. 5. In the TST, single treatments of the EEPJ(50㎎/㎏) significantly reduced the immobility time versus vehicle. Conclusions :　These results indicate that EEPJ is an effective antidepressant and antianxiolytic activity in mice, and it might be usefully applied for prevention and treatment of depressive disorder through evolutive study like development of various experimental models.

Abstract

Objectives :The purpose of this study was to characterize the putative antidepressant and antianxiolytic effects of the 70% ethanol extract of Polygala japonica(EEPJ) using animal's behavioral experiment in mice. Methods :The effect of EEPJ on the anxioty and depressive disorder was investigated via mice's behavioral experiment like Elevated plus-maze, Horizontal wire test, Open field test, Forced swimming test, Tail suspension test, and it was happen via any mechanism by WAY 100635, a 5-HT1A receptor antagonist and by Flumazenil, a GABAA antagonist Results :1. In the EPM, single treatments of the EEPJ(200 and 400㎎/㎏) had usefully antianxiolytic effects versus vehicle, which was medicated via the serotonergic nervous system. 2. In the HWT, single treatments of the EEPJ were no changes in the myorelaxant effects versus vehicle. 3. In the OFT, single treatments of the EEPJ were no changes in the locomotor activity versus vehicle. 4. In the FST, single treatments of the EEPJ(50㎎/㎏) significantly reduced the immobility time versus vehicle. 5. In the TST, single treatments of the EEPJ(50㎎/㎏) significantly reduced the immobility time versus vehicle. Conclusions :　These results indicate that EEPJ is an effective antidepressant and antianxiolytic activity in mice, and it might be usefully applied for prevention and treatment of depressive disorder through evolutive study like development of various experimental models.

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