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Screening of the Positive Inotropic Activity of Medicinal Plants Used in Oriental Medicine

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Abstract

Aqueous extracts of medicinal plants traditionally used in the East Asia such as China, Korea, and Japan were screened for inotropic activity using isolated rabbit atria. Among the twenty-one aqueous-extracts from medicinal plants, the aqueous extracts of Convallaria keiskei (ACK) and rhizome of Coptis chinensis (ACC) were found to exhibit distinctive positive inotropic activity. The aqueous extracts of C. keiskei and rhizome of C. chinensis significantly increased atrial stroke volume and pulse pressure in beating rabbit atria. These findings suggest that the aqueous extracts of C. keiskei and rhizome of C. chinensis enhance the cardiac muscle contractility and then could be useful for the treatment of cardiac failure.

참고문헌 (30)

  1. Alpert, N.R.,, "The failing human heart", pp.1~10 (2002)
  2. Francis, G.S, "Pathophysiology of chronic heart failure", pp.37~46 (2001)
  3. Braunwald, E.,, "Congestive heart failure: fifty years of progress", pp.14~102 23 (2000)
  4. Katzung, B.G.,, "Cardiac Glycosides & Other Drugs Used in Congestive Heart Failure" (2001), McGraw Hill
  5. Felker, G.M.,, "Inotropic therapy for heart failure", pp.393~401 (2001)
  6. Konstam, M.A.,, "Contemporary medical options for treating patients with heart failure", pp.2244~105 2246 (2002)
  7. Lonn, E.,, "Drug treatment in heart failure", pp.1188~1192 (2000)
  8. Cho, K.W.,, "Mechanical basis of ANP secretion in beating atria", me and ecf translocation, pp.1129~1136 (1995)
  9. Guyton, A.C.,, "Textbook of medical physiology", pp.107~119 (1996)
  10. Hasenfuss, G.,, "Calcium cycling in congestive heart failure", pp.951~969 (2002)
  11. Smith, "mechanism and manifestation of toxicity Progress in Cardiovascular Diseases 26", pp.495~540 (1984)
  12. Reuter, H.,, "The Na+-Ca2+ exchanger is essential for the action of cardiac glycosides", pp.1295~1301 (2001)
  13. Leier, C.V.,, "Parenteral inotropic support for advanced congestive heart failure", pp.207~224 (1998)
  14. Katz,A, "Potential deleterious effect of inotropic agents in the therapy of chronic heart failure", 73, pp.184~190 (1986)
  15. A, "Comparison of the cardiodynamic and metabolic effects of dobutamine with those of norepinephrine and dopamine in the isolated heart", pp.174~179 (1988)
  16. Tang, "Chinese crugs of plant origine and used in traditional and modern medicine", pp.361~371 (1992), Springer-Verlag
  17. Schmeller, T.,, "Biochemical activities of berberine palmatine and sanguinarine mediating chemical defence against microorganisms and herbivores", pp.257~266 (1997)
  18. Kitagawa, "Berberine sulfate inhibits tumor-promoting activity of teleocidin in two-stage carcinogenesis on mouse skin", nishi, pp.131~43 134 (1986)
  19. Lau, C.W.,, "Cardiovascular action of berberine", pp.234~244 (2001)
  20. Sack, "Berberine inhibits intestinal secretory response of Vibrio chlerae and Escherichia coli enterotoxins", pp.471~475 (1982)
  21. Zeng, X.,, "Relationship between the clinical effects of berberine on severe congestive heart failure and its concentration in plasma studied by HPLC", pp.442~444 (1999)
  22. Ko, W.H.,, "Vasorelaxant and antiproliferative effect of berberine European Journal of Pharmacology 399" (2000)
  23. Chun, "A biochemical study on the hypotensive effect of berberine in rats", pp.177~182 (1979)
  24. Kang, D.G.,, "Effects of berberine on angiotensin-converting enzyme and NO", cGMP system in vessels, 2002, 281~286
  25. Kimura, "The constituents of Convallaria The isolation of desglucocheirotoxin Japanese Journal of Pharmacology 82", pp.1320~1323 (1962)
  26. Kimura, "The constituents of Convallaria The isolation of convallasaponin-A", pp.50~55 (1966)
  27. Kimura, "The constituents of Convallaria Structure of convallagenin-A", pp.1204~1211 (1967)
  28. Wolfgang, "Zur biogenese von strophanthidin-glycosiden Convallatoxol als vorstufe von convallatoxin in Convallaria majalis" (1974)
  29. Ozaki, "Interaction of palytoxin and cardiac glycosides on erythrocyte membranes and Na+-K+ ATPase European Journal of Biochemistry 152", pp.475~480 (1985)
  30. Ozaki, "Interaction of palytoxin and cardiac glycosides on erythrocyte membranes and Na+-K+ ATPase European Journal of Biochemistry 152", pp.475~480 (1985)

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