소양인형방패독산의 생쥐 소교세포에서 지질다당질에 의한 cyclooxygenage-2와 inducible nitric oxide synthase 발현에 미치는 영향
Effects of Lesser Yang Person-Hyungbangpaedok-san on Lipopolysaccharide-induced Expressions of cyclooxygenase-2 and Inducible Nitric Oxide Synthase in Mouse BV2 Microglial Cells
2
조회
0
다운로드
1
인용
0
참고문헌
초록
Abstract
Lesser yang person-Hyungbangpaedok-san (HBPDS) is a prescription originated in the <Longevity and Life Preservation in Eastern Medicinewritten by Je-Ma Lee who was Korean physician of the late Chosun Dynasity. Generally, HBPDS has been used for the treatment of Lesser yang (Shao yang) person's ‘exterior cold disease induced from the spleen affected by cold. In the present study, we investigated the effect of aqueous extract of the HBPDS against lipopolysaccharide (LPS)-induced inflammation by using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, prostaglandin E2 (PGE2) immunoassay, and nitric oxide (NO) detection in mouse BV2 microglial cells. In the present results, the aqueous extract of HBPDS suppresses PGE2 synthesis and nitric oxide (NO) production and also inhibits the LPS-induced cyclooxygenase-2 (COX-2) in mouse BV2 cells. These results demonstrate that HBPDS can be used as a valuable therapy for the treatment of allergic disease, pain, and inflammation.
참고문헌 (21)
- "Neuropeptide regulation of proinflammatory cytokine responses", 63, pp.602~605 (1998)
- "Microglia: a sensor for pathological events in the CNS", 19, pp.312~318 (1996)
- "Activation of adenosine A3 receptor suppresses lipopolysaccharide- induced TNF- production through inhibition of PI 3-kinase", Akt and NF-B activation in murine BV2 microglial cells, 2006, pp.396, 1~6
- "Cyclooxygenase-2: regulation and relevance in inflammation", 50, pp.1535~1542 (1995)
- "Basic biology and clinical application of specific cyclooxygenase-2 inhibitors", 43, pp.4~13 (2000)
- "Expression and regulation of cyclooxygenase-2 in rat microglia", 243, pp.726~731 (1997)
- "S.H. A novel neuronal messenger molecule in brain", pp.297~311 (1992)
- "C. Purification of nitric oxide synthase from rat macrophages. J. Biol. Chem. 266", pp.12544~12547 (1991)
- "少陽人荊防敗毒散으로 몇 가지 頑固한 頭痛을 治療한 체험. 사상의학회지 6", pp.49~50 (1994)
- "少陽人 荊防敗毒散의 效能에 關한 實驗的 硏究. 사상의학회지 1", pp.171~181 (1989)
- "外科理例 in 四庫全書 醫家類", 33, pp.279~ (1995), 서울, 大星文化社 영인본
- "太平惠民和劑局方 in 四庫全書 醫家類 9권", pp.502~ (1995), 서울, 大星文化社 영인본
- "The pain of being sick: implications of immune-to-brain communication for understanding pain", 51, pp.29~57 (2000)
- "Microglia as mediators of inflammatory and degenerative diseases", 22, pp.219~240 (1999)
- "Role and regulation of cyclooxygenase-2 during inflammation", 106, pp.S37~S42 (1999)
- "Cyclosporin A and tacrolimus (FK506) suppress expression of inducible nitric oxide synthase in vitro by different mechanisms", 128, pp.337~344 (1999)
- "Therapy of inflammatory bowel disease", 118, pp.S68~S82 (2000)
- "Regulation of constitutive cyclooxygenase-2 expression in colon carcinoma cells", 275, pp.33951~33956 (2000)
- "D.A. Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation. Proc. Natl. Acad. Sci. USA. 91", pp.2046~2050 (1994)
- "Possible role of nitric oxide in anxiety following transient cerebral ischemia in mice", 91, pp.47~52 (2003)
- "The mode of action of aspirin-like drugs: effect on inducible nitric oxide synthase", 92, pp.7926~7930 (1995)