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HL-60 세포에 대한 건강의 분화유도 효과

Effect of Rhizoma Zingiberis Siccatum Extract on the Induction of HL-60 human leukemia cell differentiation

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Abstract

We have examined the induction of HL-60 cell differentiation by treatment of the water extract of Rhizoma Zingiberis Siccatum, which is a Korean traditional herbal medicine. It was observed that HL-60 cell proliferation was dose-dependently inhibited by treatment with various dose of Rhizoma Zingiberis Siccatum extract. The level of inhibition was identical to those of ATRA-treated cells. Rhizoma Zingiberis Siccatum extract treatment caused a significant change in NBT reduction (47%) and enhanced ATRA-induced NBT reduction. Treatment of Rhizoma Zingiberis Siccatum to HL-60 cells increased only CD11b expression in the cells, and also increased markedly G0/G1 stage arrest. This can suggest that Rhizoma Zingiberis Siccatum induced the differentiation of HL-60 cell and enhanced ATRA-induced differentiation predominantly along the granulocytic lineage. The results present here show that Rhizoma Zingiberis Siccatum extract contains the potential effect of differentiation induction or acts as a agent enhancing the induction of differentiation.

참고문헌 (29)

  1. Bestilny, L.J.,, "A role for serine proteases in mediating phorbol ester-induced differentiation of HL-60 cells", pp.264~271 (2000)
  2. Collins, "Induction of differentiation of the human promyelocytic leukemia cell line", by reti(ic acid), pp.2936~60 2940 (1980)
  3. Brown, G.,, "HL60 cells halted in G1 or S phase differentiate normally", pp.28~38 (2002)
  4. Camarasa, M.V.,, "Differentiation and drug resistance relationships in leukemia cells", pp.98~108 (2005)
  5. Chung, T.W.,, "Molecular mechanism for transcriptional activation of ganglioside GM3 synthase and its function in differentiation of HL-60 cells", pp.233~244 (2005)
  6. Datto, M.B.,, "Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism", pp.5545~5549 (1995)
  7. Degos, L.,, "All-trans-retinoic acid as a differentiating agent in the treatment of acute promyelocytic leukemia", pp.2643~2653 (1995)
  8. Drayson, M.T.,, "Cell proliferation and CD11b expression are controlled independently during HL60 cell differentiation initiated by 1", pp.126~134 (2001)
  9. Gianni, M.,, "differentiation and apoptosis in acute promyelocytic leukemia cells Expression and activation of caspases", reti(id-dependent growth inhibition), pp.447~460 (2000)
  10. Back, "Regulation of expression of the CD11b and CD18 subunits of the neutrophil adherence receptor during human myeloid differentiation", pp.21812~21817 (1987)
  11. Baker, "Identification of the promoter of the myelomonocytic leukocyte integrin CD11b", pp.2105~2109 (1992)
  12. Horie, N.,, "Implication of CDK inhibitors p21 and p27 in the differentiation of HL-60 cells", pp.992~997 (2004)
  13. Huang, W.W.,, "Pycnogenol induces differentiation and apoptosis in human promyeloid leukemia HL-60 cells", pp.685~692 (2005)
  14. James, S.Y.,, "The role of vitamin D derivatives and retinoids in the differentiation of human leukaemia cells", pp.625~634 (1997)
  15. Kong, G.,, "Induction of granulocytic differentiation in acute promyelocytic leukemia cells", pp.1~60 8 (1999)
  16. Lee, K.H.,, "Differential gene expression in retinoic acid-induced differentiation of acute promyelocytic leukemia cells", pp.1125~1133 (2002)
  17. Makishima, M.,, "Induction of differentiation in acute promyelocytic leukemia cells by 9-cis retinoic acid alpha-tocopherol ester", umeso 9-cis treti(in tocoferil), pp.4715~4726 (1998)
  18. Mishima, S.,, "Identification of caffeoylquinic acid derivatives from Brazilian propolis as constituents involved in induction of granulocytic differentiation of HL-60 cells", i(h zawa), pp.5814~5818 (1995)
  19. Greenberger, "Functional changes in human leukemic cell line HL-60 A model for myeloid differentiation", pp.315~322 (1979)
  20. Noble, J.M.,, "Effect of aging on CD11b and CD69 surface expression by vesicular insertion in human polymorphonuclear leucocytes", pp.323~329 (1999)
  21. Pae, H.O.,, "Induction of granulocytic differentiation in acute promyelocytic leukemia cells", pp.339~60 346 (2001)
  22. Prall, O.W.,, "Estrogen-induced activation of Cdk4 and Cdk2 during G1-S phase progression is accompanied by increased cyclin D1 expression and decreased cyclin-dependent kinase inhibitor association with cyclin E-Cdk2", pp.10882~10894 (1997)
  23. Roberts, "Differentiation-linked changes in tyrosine phosphorylation and gene expression downstream from the granulocyte-macrophage colony-stimulating factor receptor", pp.1064~1073 (1994), Linch
  24. Sachs, "Constitutive uncoupling of pathways of gene expression that control growth and differentiation in myeloid leukemia a model for the origin and progression of malignancy", pp.6152~6156 (1980)
  25. Schwaller, J.,, "Posttranscriptional stabilization underlies p53-independent induction of p21WAF1", CIP1, pp.1995[DOI]
  26. Tsiftsoglou, A.S.,, "Mechanisms involved in the induced differentiation of leukemia cells", pp.257~290 (2003)
  27. Yang, L.,, "Gene expression profiling during all-trans retinoic acid-induced cell differentiation of acute promyelocytic leukemia cells", pp.212~221 (2003)
  28. Zhu, B.,, "8-chloroadenosine induced HL-60 cell growth inhibition, differentiation, and G(0)", G(1) arrest involves attenuated cyclin D1 and telomerase and up-regulated p21(WAF1, pp.2005, es attenuated cyclin d1 and telomerase and up-regulated p21[DOI]
  29. Zhu, B.,, "8-chloroadenosine induced HL-60 cell growth inhibition, differentiation, and G(0)", G(1) arrest involves attenuated cyclin D1 and telomerase and up-regulated p21(WAF1, pp.2005, es attenuated cyclin d1 and telomerase and up-regulated p21[DOI]

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