蘇合香이 신경 세포에서 베타 아밀로이드 분비에 미치는 영향
Effects of Styrax Liquides on the Secretion of β-amyloid Precursor Protein in Neuroblastoma Cells
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Alzheimer's disease (AD) is characterized pathologically by the presence of intracellular neurofibrillary tangles and deposition of β-amyloid (Aβ) peptides. It is urgent to develop effective therapies for the treatment of AD, since our society rapidly accelerate aging. Aβ peptides have been believed to be neurotoxic and now are also considered to have affects on the mechanism of memory formation, which are generated by processing of amyloid precursor protein (APP). In this study, effects of Styrax Liquides (SL) on the metabolism of APP were analyzed. SL inhibited the secretion of Aβ from the Neuro2a cell line (APPswe cell) expressing a mutation of APPswe. Immunoblotting study showed that it inhibited β-site APP cleaving enzyme (BACE) from the APPswe cells. We suggest that SL inhibits APP metabolism and Aβ generation by the means of BACE inhibitory mechanism. This is the first report that SL inhibits the secretion of Aβ peptides from neuroblastoma cells.
Abstract
Alzheimer's disease (AD) is characterized pathologically by the presence of intracellular neurofibrillary tangles and deposition of β-amyloid (Aβ) peptides. It is urgent to develop effective therapies for the treatment of AD, since our society rapidly accelerate aging. Aβ peptides have been believed to be neurotoxic and now are also considered to have affects on the mechanism of memory formation, which are generated by processing of amyloid precursor protein (APP). In this study, effects of Styrax Liquides (SL) on the metabolism of APP were analyzed. SL inhibited the secretion of Aβ from the Neuro2a cell line (APPswe cell) expressing a mutation of APPswe. Immunoblotting study showed that it inhibited β-site APP cleaving enzyme (BACE) from the APPswe cells. We suggest that SL inhibits APP metabolism and Aβ generation by the means of BACE inhibitory mechanism. This is the first report that SL inhibits the secretion of Aβ peptides from neuroblastoma cells.
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