만성 림프구성 백혈병을 동반한 하시모토 갑상선염 1예
A case of Hashimoto's thyroiditis with chronic lymphocytic leukemia
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초록
저자들은 하시모토 갑상선염으로 10년간 갑상선호르몬을 지속적으로 복용하고 있던 환자가 갑자기 발생한 압통을 동반한 갑상선종의 비대를 주소로 내원하여 시행한 혈액검사에서 T세포 만성 림프구성 백혈병을 진단받고 항암치료 후 갑상선종의 현저한 감소와 항갑상선글로불린항체가의 감소를 보인 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.
Abstract
Hashimoto's thyroiditis is an autoimmune thyroid disease characterized by a gradual enlargement of the thyroid gland, extensive lymphocytic infiltration and fibrosis of thyroid follicles. Hashimoto's thyroiditis occurs frequently in conjunction with a wide range of organ-specific and systemic autoimmune diseases. The association of chronic lymphocytic leukemia with other autoimmune diseases also has been recognized. Here, we report a case of chronic lymphocytic leukemia diagnosed by abrupt painful swelling of the thyroid gland in a 69-year-old woman with Hashimoto's thyroiditis. The painful enlargement of goiter and elevated levels of antibodies to thyroglobulin were improved after chemotherapy with cyclophosphamide, vicristine and prednisolone.(Korean J Med 70:101-106, 2006)
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