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후성유전과 알레르기 질환

Epigenetics in Allergic Diseases

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초록

후성유전이 천식 및 알레르기 질환에 미치는 영향은 앞으로 많은 연구가 필요하며 이런 연구를 통해서 1) 알레르기를일으키는 원인인 알러젠, 대기오염, 담배연기, 바이러스 등이 천식에서 후성유전의 변화를 가져올 것인지, 2) 천식의임상 경과 중 엄마 뱃속에서부터 그 이후로 출생과정, 성장과정 중 어느 과정에 영향을 주는지, 환경요인에 의해 연령에 따라 다른 영향을 주는지, 한 번 생긴 변화가 바뀔 것인지, 3) 후성유전이 유전자와 상호작용은 어떠한지, 4) 후성유전의 변화를 알거나 제어할 수 있는 생체 마커는 무엇인지등에 대한 연구가 이루어져 천식 및 알레르기 질환에 후생유전이 미치는 영향이 파악되고 이러한 영향을 줄이거나 극복하는 치료제가 나오기를 기대한다.

Abstract

The epigenetics is the study of changes in gene expression or celluar phenotype caused by mechanisms other than changes in the underlying DNA sequence. Epigenetic regulation in asthma and allergic diseases is an interesting area that has obtained a great deal of scientific concern in recent years. Allergic diseases such as asthma and allergic rhinitis in early life are one of the important indicators that the developing immune system is vulnerable to biologic and environmental pollutants. The epigenetic studies are likely to provide clear and deep understandings into how the environment can be modified to drive immune development and change the allergic disease phenotypes. This review includes 1) definition of epigenetics 2) regulation of epigenetics 3) characterization of environmental asthma and allergic diseases triggers that induce epigenetic changes.

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