논문KCI 등재
기관지천식의 유전적 요소
Genetic Factors in Bronchial Asthma
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참고문헌
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초록
천식의 유전적 소인을 밝히기 위한 연구는 cDNA 마이크로 어레이를 이용한 유전자 발현 차이 조사 연구와 단일 염기 다형성을 이용한 유전자 연관성 연구로 대변할 수 있다. 그 연구 결과를 토대로 지금까지 많은 유전자들이 천식 표현형과의 연관성이 보고되고 있으며 해당 유전자들의 기능 연구를 통해 분자 수준의 기전을 밝힘으로서 천식의 병인기전을 이해하고 새로운 치료제를 개발하는데 응용하고자 한다. 향후 더 많은 연구결과가 축적되면, 유전자 정보에 근거하여, 천식과 약물 알레르기 환자의 표현형을 예측하기 위한 진단법 개발과 치료제에 대한 반응 및 약물 이상반응을 예측하여 개인에 따른 맞춤치료를 적용할 수 있는 시대가 오리라 기대한다.
Abstract
Bronchial asthma is a chronic inflammatory disease of the airways in which there isincreased responsiveness to various stimuli, resulting in wheezing, shortness of breath, and coughing. Interactions between environmental and genetic factors may modify both the susceptibility to and severity of the disease. In recent years, much progress has been made in improving our understanding of the genetic basis of bronchial asthma, which has led to the identification of several genetic factors. This review is an update of genetic studies of bronchial asthma and recent findings.
참고문헌 (33)
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