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천식과 후성유전학

Asthma and epigenetics

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주제분류소아과학

초록

For the past two decades, a huge number of genetic studies have been conducted to identify the genetic variants responsible for asthma risk. Several types of genetic and genomic approaches, including linkage analysis, candidate gene single nucleotide polymorphism studies, and whole genome-wide association studies have been applied. However, the genetic impacts of these studies are minimal because asthma is a complex syndrome affected by interaction with many environmental factors mediated by epigenetics. Epigenetics is alteration of genetic expression without changes of DNA sequence. Three major forms of epigenetic is DNA methylation, histone modfications and specific microRNA expression that are known to have vast effects on gene expression. However, knowledge regarding the epigenetic effect on the development of asthma and its traits is limited up to date. Recently, new data on epigenetics have been brought up to explain the phenotypic alterations of asthma. In this review, we present general concept of epigenetics, environmental factors inducting epigenetic changes and the background mechanisms in epigenetics behind development asthma and epigenetic therapy.

Abstract

For the past two decades, a huge number of genetic studies have been conducted to identify the genetic variants responsible for asthma risk. Several types of genetic and genomic approaches, including linkage analysis, candidate gene single nucleotide polymorphism studies, and whole genome-wide association studies have been applied. However, the genetic impacts of these studies are minimal because asthma is a complex syndrome affected by interaction with many environmental factors mediated by epigenetics. Epigenetics is alteration of genetic expression without changes of DNA sequence. Three major forms of epigenetic is DNA methylation, histone modfications and specific microRNA expression that are known to have vast effects on gene expression. However, knowledge regarding the epigenetic effect on the development of asthma and its traits is limited up to date. Recently, new data on epigenetics have been brought up to explain the phenotypic alterations of asthma. In this review, we present general concept of epigenetics, environmental factors inducting epigenetic changes and the background mechanisms in epigenetics behind development asthma and epigenetic therapy.

참고문헌 (58)

  1. Ahmed F, "Epigenetics: tales of adversity", Nature, 468, pp.20~ (2010)
  2. Cortessis VK, "Environmental epigenetics: prospects for studying epigenetic mediation of exposure-response relationships", Hum Genet, 131, pp.1565~1589 (2012)
  3. Bell JT, "A twin approach to unraveling epigenetics", Trends Genet, 27, pp.116~125 (2011)
  4. Turker MS, "Formation of methylation patterns in the mammalian genome", Mutat Res, 386, pp.119~130 (1997)
  5. Okitsu CY, "DNA methylation dictates histone H3K4 methylation", Mol Cell Biol, 27, pp.2746~2757 (2007)
  6. Peterson CL, "Histones and histone modifications", Curr Biol, 14, pp.546~551 (2004)
  7. Kitamoto S, "DNA methylation and histone H3-K9 modifications contribute to MUC17 expression", Glycobiology, 21, pp.247~256 (2011)
  8. Stewart MD, "Relationship between histone H3 lysine 9 methylation, transcription repression, and heterochromatin protein 1 recruitment", Mol Cell Biol, 25, pp.2525~2538 (2005)
  9. Cedar H, "Linking DNA methylation and histone modification: patterns and paradigms", Nat Rev Genet, 10, pp.295~304 (2009)
  10. Chuang JC, "Epigenetics and microRNAs", Pediatr Res, 61(5 Pt 2), pp.24R~29R (2007)
  11. Chen K, "The evolution of gene regulation by transcription factors and microRNAs", Nat Rev Genet, 8, pp.93~103 (2007)
  12. Sayed D, "MicroRNAs in development and disease", Physiol Rev, 91, pp.827~887 (2011)
  13. Miller RL, "Environmental epigenetics and asthma: current concepts and call for studies", Am J Respir Crit Care Med, 177, pp.567~573 (2008)
  14. Gilliland FD, "Effects of early onset asthma and in utero exposure to maternal smoking on childhood lung function", Am J Respir Crit Care Med, 167, pp.917~924 (2003)
  15. Li YF, "Maternal and grandmaternal smoking patterns are associated with early childhood asthma", Chest, 127, pp.1232~1241 (2005)
  16. Magnusson LL, "Wheezing, asthma, hayfever, and atopic eczema in childhood following exposure to tobacco smoke in fetal life", Clin Exp Allergy, 35, pp.1550~1556 (2005)
  17. Alati R, "In utero and postnatal maternal smoking and asthma in adolescence", Epidemiology, 17, pp.138~144 (2006)
  18. Kurukulaaratchy RJ, "Does environment mediate earlier onset of the persistent childhood asthma phenotype?", Pediatrics, 113, pp.345~350 (2004)
  19. Miller RL, "Polycyclic aromatic hydrocarbons, environmental tobacco smoke, and respiratory symptoms in an inner-city birth cohort", Chest, 126, pp.1071~1078 (2004)
  20. Enstrom JE, "Environmental tobacco smoke and tobacco related mortality in a prospective study of Californians, 1960-98", BMJ, 326, pp.1057~ (2003)
  21. Dolinoy DC, "Epigenetic gene regulation: linking early developmental environment to adult disease", Reprod Toxicol, 23, pp.297~307 (2007)
  22. Tang WY, "Epigenetic reprogramming and imprinting in origins of disease", Rev Endocr Metab Disord, 8, pp.173~182 (2007)
  23. Devereux G, "Low maternal vitamin E intake during pregnancy is associated with asthma in 5-year-old children", Am J Respir Crit Care Med, 174, pp.499~507 (2006)
  24. Jedrychowski W, "The prenatal use of antibiotics and the development of allergic disease in one year old infants. A preliminary study", Int J Occup Med Environ Health, 19, pp.70~76 (2006)
  25. Kukkonen K, "Probiotics and prebiotic galacto-oligosaccharides in the prevention of allergic diseases: a randomized, double-blind, placebocontrolled trial", J Allergy Clin Immunol, 119, pp.192~198 (2007)
  26. Fitzsimon N, "Mothers' dietary patterns during pregnancy and risk of asthma symptoms in children at 3 years", Ir Med J, 100, pp.27~32 (2007)
  27. Hamada K, "Exposure of pregnant mice to an air pollutant aerosol increases asthma susceptibility in offspring", J Toxicol Environ Health A, 70, pp.688~695 (2007)
  28. Fedulov AV, "Pulmonary exposure to particles during pregnancy causes increased neonatal asthma susceptibility", Am J Respir Cell Mol Biol, 38, pp.57~67 (2008)
  29. Blümer N, "Prenatal lipopolysaccharideexposure prevents allergic sensitization and airway inflammation, but not airway responsiveness in a murine model of experimental asthma", Clin Exp Allergy, 35, pp.397~402 (2005)
  30. Blumer N, "Perinatal maternal application of Lactobacillus rhamnosus GG suppresses allergic airway inflammation in mouse offspring", Clin Exp Allergy, 37, pp.348~357 (2007)
  31. Rahman I, "Oxidative stress, chromatin remodeling and gene transcription in inflammation and chronic lung diseases", J Biochem Mol Biol, 36, pp.95~109 (2003)
  32. Rahman I, "Redox modulation of chromatin remodeling: impact on histone acetylation and deacetylation, NF-kappaB and pro-inflammatory gene expression", Biochem Pharmacol, 68, pp.1255~1267 (2004)
  33. Ito K, "Expressionand activity of histone deacetylases in human asthmatic airways", Am J Respir Crit Care Med, 166, pp.392~396 (2002)
  34. Gilliland FD, "Maternal smoking during pregnancy, environmental tobacco smoke exposure and childhood lung function", Thorax, 55, pp.271~276 (2000)
  35. Bush A, "Phenotypic differences between pediatric and adult asthma", Proc Am Thorac Soc, 6, pp.712~719 (2009)
  36. Mandhane PJ, "Sex differences in factors associated with childhood- and adolescent-onset wheeze", Am J Respir Crit Care Med, 172, pp.45~54 (2005)
  37. Perera FP, "Effects of transplacental exposure to environmental pollutants on birth outcomes in a multiethnic population", Environ Health Perspect, 111, pp.201~205 (2003)
  38. Windham GC, "Prenatal active or passive tobacco smoke exposure and the risk of preterm delivery or low birth weight", Epidemiology, 11, pp.427~433 (2000)
  39. Su RC, "Altered epigenetic regulation and increasing severity of bronchial hyperresponsiveness in atopic asthmatic children", J Allergy Clin Immunol, 124, pp.1116~1118 (2009)
  40. Nadeau K, "Ambient air pollution impairs regulatory T-cell function in asthma", J Allergy Clin Immunol, 126, pp.845~852 (2010)
  41. Cheong HS, "Genomewide methylation profile of nasal polyps: relation to aspirin hypersensitivity in asthmatics", Allergy, 66, pp.637~644 (2011)
  42. Lee JS, "Association of CACNG6 polymorphisms with aspirin-intolerance asthmatics in a Korean population", BMC Med Genet, 11, pp.138~ (2010)
  43. Yoo CB, "Epigenetic therapy of cancer: past, present and future", Nat Rev Drug Discov, 5, pp.37~50 (2006)
  44. Juergens RA, "Combination epigenetic therapy has efficacy in patients with refractory advanced non-small cell lung cancer", Cancer Discov, 1, pp.598~607 (2011)
  45. Egger G, "Epigenetics in human disease and prospects for epigenetic therapy", Nature, 429, pp.457~463 (2004)
  46. Chen M, "DNA methyltransferase inhibitor, zebularine, delays tumor growth and induces apoptosis in a genetically engineered mouse model of breast cancer", Mol Cancer Ther, 11, pp.370~382 (2012)
  47. Billam M, "Effects of a novel DNA methyltransferase inhibitor zebularine on human breast cancer cells", Breast Cancer Res Treat, 120, pp.581~592 (2010)
  48. Breton CV, "Prenatal tobacco smoke exposure affects global and gene-specific DNA methylation", Am J Respir Crit Care Med, 180, pp.462~467 (2009)
  49. Ito K, "Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophages", FASEB, 15, pp.1110~1112 (2001)
  50. Launay JM, "Smoking induces long-lasting effects through a monoamine-oxidase epigenetic regulation", PLoS One, 4, pp.7959~ (2009)
  51. Perera F, "Relation of DNA methylation of 5'-CpG island of ACSL3 to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthma", PLoS, 4, pp.e4488~ (2009)
  52. Tang WY, "Maternal exposure to polycyclic aromatic hydrocarbons and 5'-CpG methylation of interferon-γ in cord white blood cells", Environ Health Perspect, 120, pp.1195~1200 (2012)
  53. Kwon NH, "DNA methylation and the expression of IL-4 and IFN-gamma promoter genes in patients with bronchial asthma", J Clin Immunol, 28, pp.139~146 (2008)
  54. Breton CV, "DNA methylation in the arginase-nitric oxide synthase pathway is associated with exhaled nitric oxide in children with asthma", Am J Respir Crit Care Med, 184, pp.191~197 (2011)
  55. Wu W, "GSTM1 modulation of IL-8 expression in human bronchial epithelial cells exposed to ozone", Free Radic Biol Med, 51, pp.522~529 (2011)
  56. Chiba T, "Inflammation-associated cancer development in digestive organs: mechanisms and roles for genetic and epigenetic modulation", Gastroenterology, 143, pp.550~563 (2012)
  57. Barnes PJ, "Histone acetylation and deacetylation: importance in inflammatory lung diseases", Eur Respir J, 25, pp.552~563 (2005)
  58. Haberg SE, "Folic acid supplements in pregnancy and early childhood respiratory health", Arch Dis Child, 94, pp.180~184 (2009)

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