말단비대증 환자에서 소마토스타틴 유사체 사용에 대한 권고안
Medical Treatment with Somatostatin Analogues in Acromegaly: Position Statement
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Acromegaly is a chronic disorder caused by excessive growth hormone (GH) secretion. In most cases, the excess GH originates from GH-producing pituitary adenomas. Surgery is the preferred first-line treatment for patients with acromegaly, but medical management is considered when the disease persists after surgery or in cases where patients refuse surgery or are poor candidates for surgery. Somatostatin analogues are commonly used to treat acromegaly. The Korean Endocrine Society and the Korean Neuroendocrine Study Group have developed a position statement for the use of somatostatin analogues in the medical treatment of acromegaly. This position statement is based on evidence from the current literature and expert opinions. In the case of discrepancies among expert opinions, the experts voted to determine the recommended approach.
Abstract
Acromegaly is a chronic disorder caused by excessive growth hormone (GH) secretion. In most cases, the excess GH originates from GH-producing pituitary adenomas. Surgery is the preferred first-line treatment for patients with acromegaly, but medical management is considered when the disease persists after surgery or in cases where patients refuse surgery or are poor candidates for surgery. Somatostatin analogues are commonly used to treat acromegaly. The Korean Endocrine Society and the Korean Neuroendocrine Study Group have developed a position statement for the use of somatostatin analogues in the medical treatment of acromegaly. This position statement is based on evidence from the current literature and expert opinions. In the case of discrepancies among expert opinions, the experts voted to determine the recommended approach.
참고문헌 (59)
- Melmed S, "Acromegaly pathogenesis and treatment", J Clin Invest, 119, pp.3189~3202 (2009)
- Reid TJ, "Features at diagnosis of 324 patients with acromegaly did not change from 1981 to 2006: acromegaly remains under-recognized and under-diagnosed", Clin Endocrinol (Oxf), 72, pp.203~208 (2010)
- Kwon O, "Nationwide survey of acromegaly in South Korea", Clin Endocrinol(Oxf), 78, pp.577~585 (2013)
- Katznelson L, "Acromegaly : an endocrine society clinical practice guideline", J Clin Endocrinol Metab, 99, pp.3933~3951 (2014)
- Wass JA, "The importance of locating a good pituitary surgeon", Pituitary, 2, pp.51~54 (1999)
- Ahmed S, "Outcome of transphenoidal surgery for acromegaly and its relationship to surgical experience", Clin Endocrinol(Oxf), 50, pp.561~567 (1999)
- Shimon I, "Transsphenoidal surgery for acromegaly : endocrinological follow-up of 98patients", Neurosurgery, 48, pp.1239~1243 (2001)[DOI]
- McLaughlin N, "Pituitary centers of excellence", Neurosurgery, 71, pp.916~924 (2012)[DOI]
- Kreutzer J, "Surgical management of GH-secreting pituitary adenomas : an outcome study using modern remission criteria", J Clin Endocrinol Metab, 86, pp.4072~4077 (2001)
- 최재호, "Endocrine Outcome of Endoscopic Endonasal Transsphenoidal Surgery in Functioning Pituitary Adenomas", 대한신경외과학회지, 44(3), pp.151~155 (2008), 대한신경외과학회
- 진상욱, "Medical Treatment with Somatostatin Analogues in Acromegaly: Position Statement", Endocrinology and Metabolism, 34(1), pp.53~62 (2019), 대한내분비학회[DOI]
- Reichlin S, "Somatostatin", N Engl J Med, 309, pp.1495~1501 (1983)
- Cuevas-Ramos D, "Somatostatin receptor ligands and resistance to treatment in pituitary adenomas", J Mol Endocrinol, 52, pp.R223~ (2014)[DOI]
- Fleseriu M, "Medical management of Cushing's disease: what is the future?", Pituitary, 15, pp.330~341 (2012)
- Reubi JC, "Expression and localization of somatostatin receptor SSTR1, SSTR2, and SSTR3 messenger RNAs in primary human tumors using in situ hybridization", Cancer Res, 54, pp.3455~3459 (1994)
- Krantic S, "Novel modalities of somatostatin actions", Eur J Endocrinol, 151, pp.643~655 (2004)
- Maffezzoni F, "Current and future medical treatments for patients with acromegaly", Expert Opin Pharmacother, 17, pp.1631~1642 (2016)
- Bauer W, "SMS 201-995 : a very potent and selective octapeptide analogue of somatostatin with prolonged action", Life Sci, 31, pp.1133~1140 (1982)
- Taylor JE, "In vitro and in vivo inhibition of human small cell lung carcinoma(NCI-H69)growth by a somatostatin analogue", Biochem Biophys Res Commun, 153, pp.81~86 (1988)
- Freda PU, "Somatostatin analogs in acromegaly", J Clin Endocrinol Metab, 87, pp.3013~3018 (2002)
- Grass P, "Sandostatin LAR(microencapsulated octreotide acetate)in acromegaly : pharmacokinetic and pharmacodynamic relationships", Metabolism, 45(8 Suppl 1), pp.27~30 (1996)
- McKeage K, "Octreotide long-acting release(LAR) : a review of its use in the management of acromegaly", Drugs, 63, pp.2473~2499 (2003)
- Ciccarelli A, "Lanreotide Autogel for acromegaly : a new addition to the treatment armamentarium", Treat Endocrinol, 3, pp.77~81 (2004)
- Taboada GF, "Quantitative analysis of somatostatin receptor subtype(SSTR1-5)gene expression levels in somatotropinomas and non-functioning pituitary adenomas", Eur J Endocrinol, 156, pp.65~74 (2007)
- Park C, "Somatostatin(SRIF)receptor subtype 2 and 5 gene expression in growth hormone-secreting pituitary adenomas : the relationship with endogenous srif activity and response to octreotide", Endocr J, 51, pp.227~236 (2004)
- Dietrich H, "Safety, tolerability, and pharmacokinetics of a single dose of pasireotide long-acting release in healthy volunteers : a single-center Phase I study", Eur J Endocrinol, 166, pp.821~828 (2012)
- Bruns C, "SOM230 : a novel somatostatin peptidomimetic with broad somatotropin release inhibiting factor(SRIF)receptor binding and a unique antisecretory profile", Eur J Endocrinol, 146, pp.707~716 (2002)
- Wolin EM, "Safety, tolerability, pharmacokinetics, and pharmacodynamics of a long-acting release(LAR)formulation of pasireotide(SOM230)in patients with gastroenteropancreatic neuroendocrine tumors : results from a randomized, multicenter, open-label, phase I study", Cancer Chemother Pharmacol, 72, pp.387~395 (2013)
- Jørgensen JO, "Cotreatment of acromegaly with a somatostatin analog and a growth hormone receptor antagonist", J Clin Endocrinol Metab, 90, pp.5627~5631 (2005)
- Conway-Campbell BL, "The extracellular domain of the growth hormone receptor interacts with coactivator activator to promote cell proliferation", Mol Endocrinol, 22, pp.2190~2202 (2008)
- Lamberts SW, "Long-term treatment of acromegaly with the somatostatin analogue SMS 201-995", N Engl J Med, 313, pp.1576~1580 (1985)
- Fleseriu M, "Clinical efficacy and safety results for dose escalation of somatostatin receptor ligands in patients with acromegaly : a literature review", Pituitary, 14, pp.184~193 (2011)
- Roelfsema F, "Therapeutic options in the management of acromegaly : focus on lanreotide Autogel", Biologics, 2, pp.463~479 (2008)
- Mercado M, "A prospective, multicentre study to investigate the efficacy, safety and tolerability of octreotide LAR(long-acting repeatable octreotide)in the primary therapy of patients with acromegaly", Clin Endocrinol(Oxf), 66, pp.859~868 (2007)
- Caron PJ, "Tumor shrinkage with lanreotide Autogel 120 mg as primary therapy in acromegaly : results of a prospective multicenter clinical trial", J Clin Endocrinol Metab, 99, pp.1282~1290 (2014)
- 양세정, "한국인 말단 비대증에서 long acting lanreotide의 치료", 대한내과학회지, 73(1), pp.50~57 (2007), 대한내과학회
- Colao A, "Pasireotide versus octreotide in acromegaly : a head-to-head superiority study", J Clin Endocrinol Metab, 99, pp.791~799 (2014)
- Sheppard M, "Pasireotide LAR maintains inhibition of GH and IGF-1 in patients with acromegaly for up to 25 months : results from the blinded extension phase of a randomized, double-blind, multicenter, phase III study", Pituitary, 18, pp.385~394 (2015)
- Bronstein MD, "Switching patients with acromegaly from octreotide to pasireotide improves biochemical control : crossover extension to a randomized, double-blind, phase III study", BMC Endocr Disord, 16, pp.16~ (2016)
- Gadelha MR, "Pasireotide versus continued treatment with octreotide or lanreotide in patients with inadequately controlled acromegaly(PAOLA) : a randomised, phase 3 trial", Lancet Diabetes Endocrinol, 2, pp.875~884 (2014)
- Holdaway IM, "Factors influencing mortality in acromegaly", J Clin Endocrinol Metab, 89, pp.667~674 (2004)
- Zeinalizadeh M, "Discordance between growth hormone and insulin-like growth factor-1 after pituitary surgery for acromegaly : a stepwise approach and management", Pituitary, 18, pp.48~59 (2015)
- Ayuk J, "Growth hormone and pituitary radiotherapy, but not serum insulin-like growth factor-I concentrations, predict excess mortality in patients with acromegaly", J Clin Endocrinol Metab, 89, pp.1613~1617 (2004)
- Paragliola RM, "Somatostatin receptor ligands in acromegaly : clinical response and factors predicting resistance", Pituitary, 20, pp.109~115 (2017)
- Andries M, "A 12-month randomized crossover study on the effects of lanreotide Autogel and octreotide long-acting repeatable on GH and IGF-l in patients with acromegaly", Clin Endocrinol(Oxf), 68, pp.473~480 (2008)
- 박정경, "말단비대증 환자에게서 서방형 옥트레오타이드와 란레오타이드 오토젤의 효과 비교", Endocrinology and Metabolism, 25(1), pp.25~27 (2010), 대한내분비학회
- Giustina A, "High-dose intramuscular octreotide in patients with acromegaly inadequately controlled on conventional somatostatin analogue therapy: a randomised controlled trial", Eur J Endocrinol, 161, pp.331~338 (2009)
- Neggers SJ, "Lanreotide Autogel 120 mg at extended dosing intervals in patients with acromegaly biochemically controlled with octreotide LAR : the LEAD study", Eur J Endocrinol, 173, pp.313~323 (2015)
- Orlewska E, "Dosage and costs of lanreotide Autogel 120 mg administered as part of routine acromegaly care in Poland - two years of data from Lanro-Study", Endokrynol Pol, 66, pp.142~148 (2015)
- Carlsen SM, "Preoperative octreotide treatment in newly diagnosed acromegalic patients with macroadenomas increases cure short-term postoperative rates : a prospective, randomized trial", J Clin Endocrinol Metab, 93, pp.2984~2990 (2008)
- Fougner SL, "Preoperative octreotide treatment of acromegaly : long-term results of a randomised controlled trial", Eur J Endocrinol, 171, pp.229~235 (2014)
- Strowski MZ, "Somatostatin inhibits insulin and glucagon secretion via two receptors subtypes: an in vitro study of pancreatic islets from somatostatin receptor 2 knockout mice", Endocrinology, 141, pp.111~117 (2000)
- Correa LL, "Evaluation of glucose metabolism in acromegalic patients before and after treatment with octreotide LAR", Arq Bras Endocrinol Metabol, 52, pp.55~64 (2008)
- Caron PJ, "Glucose and lipid levels with lanreotide autogel 120 mg in treatment-naïve patients with acromegaly:data from the PRIMARYS study", Clin Endocrinol (Oxf), 86, pp.541~551 (2017)
- Kumar U, "Subtype-selective expression of the five somatostatin receptors(hSSTR1-5)in human pancreatic islet cells : a quantitative double-label immunohistochemical analysis", Diabetes, 48, pp.77~85 (1999)
- Henry RR, "Hyperglycemia associated with pasireotide : results from a mechanistic study in healthy volunteers", J Clin Endocrinol Metab, 98, pp.3446~3453 (2013)
- Colao A, "Managing hyperglycemia in patients with Cushing's disease treated with pasireotide : medical expert recommendations", Pituitary, 17, pp.180~186 (2014)
- Maffei P, "Effects of octreotide exposure during pregnancy in acromegaly", Clin Endocrinol(Oxf), 72, pp.668~677 (2010)
- Caron P, "Acromegaly and pregnancy : a retrospective multicenter study of 59 pregnancies in 46 women", J Clin Endocrinol Metab, 95, pp.4680~4687 (2010)
