Effect of an Air Cleaner with Electrostatic Filter on the Removal of Airborne House Dust Mite Allergens
0
조회
0
다운로드
2
인용
0
참고문헌
키워드
초록
Purpose: The effects of air cleaners on the removal of airborne indoor allergens,especially house dust mites (HDM), are still controversial. The objective of this study is to evaluate the effect of an air cleaner with an electrostatic filter on the removal of airborne mite allergens. Materials and Methods: A dried HDM culture medium that contained mite body particles and excretions was dispersed in a chamber equipped with an electrostatic air cleaner. The number of airborne particles was recorded continuously by a dust spectrometer for 60 minutes. Airborne particles in the chamber were collected on a sampling filter at a flow rate of 10 L/min and the Der f 1 concentration in the filter extracts was measured by two-site ELISA. Results: The air cleaner efficiently removed airborne HDM particles. The air cleaner removed airborne HDM particles (size 2-12.5 μm) 11.4 ±2.9 fold (cleaner operating for 15 minutes), 5.4 ± 0.7 fold (cleaner operating for 30minutes), and 2.4 ± 0.2 fold (cleaner operating for 60 minutes) more than the removal of HDM particles by natural settle down. Removal kinetics differed according to the particle size of the airborne particles. The air cleaner decreased the concentration of Der f 1 in the extraction of airborne particles collected on the air sampling filter by 60.3%. Conclusion: The electrostatic air cleaner can remove airborne HDM allergens and may be useful as a supplementary environmental control tool for HDM sensitized respiratory allergic patients.
Abstract
Purpose: The effects of air cleaners on the removal of airborne indoor allergens,especially house dust mites (HDM), are still controversial. The objective of this study is to evaluate the effect of an air cleaner with an electrostatic filter on the removal of airborne mite allergens. Materials and Methods: A dried HDM culture medium that contained mite body particles and excretions was dispersed in a chamber equipped with an electrostatic air cleaner. The number of airborne particles was recorded continuously by a dust spectrometer for 60 minutes. Airborne particles in the chamber were collected on a sampling filter at a flow rate of 10 L/min and the Der f 1 concentration in the filter extracts was measured by two-site ELISA. Results: The air cleaner efficiently removed airborne HDM particles. The air cleaner removed airborne HDM particles (size 2-12.5 μm) 11.4 ±2.9 fold (cleaner operating for 15 minutes), 5.4 ± 0.7 fold (cleaner operating for 30minutes), and 2.4 ± 0.2 fold (cleaner operating for 60 minutes) more than the removal of HDM particles by natural settle down. Removal kinetics differed according to the particle size of the airborne particles. The air cleaner decreased the concentration of Der f 1 in the extraction of airborne particles collected on the air sampling filter by 60.3%. Conclusion: The electrostatic air cleaner can remove airborne HDM allergens and may be useful as a supplementary environmental control tool for HDM sensitized respiratory allergic patients.
참고문헌 (24)
- Sporik R, "Exposure to house-dust mite allergen (Der p I) and the development of asthma in childhood. A prospective study", N Engl J Med, 323, pp.502~507 (1990)
- Wahn U, "Indoor allergen exposure is a risk factor for sensitization during the first three years of life", J Allergy Clin Immunol, 99, pp.763~769 (1997)
- Eggleston PA, "Improving indoor environments: reducing allergen exposures", J Allergy Clin Immunol, 116, pp.122~126 (2005)
- Wood RA, "A placebo-controlled trial of a HEPA air cleaner in the treatment of cat allergy", Am J Respir Crit Care Med, 158, pp.115~120 (1998)
- Green R, "The effect of air filtration on airborne dog allergen", Allergy, 54, pp.484~488 (1999)
- Reisman RE, "A double-blind study of the effectiveness of a high-efficiency particulate air (HEPA) filter in the treatment of patients with perennial allergic rhinitis and asthma", J Allergy Clin Immunol, 85, pp.1050~1057 (1990)
- Antonicelli L, "Efficacy of an air-cleaning device equipped with a high efficiency particulate air filter in house dust mite respiratory allergy", Allergy, 46, pp.594~600 (1991)
- Reisman RE, "Do air cleaners make a difference in treating allergic disease in homes?", Ann Allergy Asthma Immunol, 87, pp.41~43 (2001)
- Sheikh A, "House dust mite avoidance measures for perennial allergic rhinitis", Cochrane Database Syst Rev, 24, pp.CD001563~ (2007)
- Sulser C, "Can the use of HEPA cleaners in homes of asthmatic children and adolescents sensitized to cat and dog allergens decrease bronchial hyperresponsiveness and allergen contents in solid dust", Int Arch Allergy Immunol, 148, pp.23~30 (2009)
- Waring MS, "Ultrafine particle removal and generation by portable air cleaners", Atmos Environ, 42, pp.5003~5014 (2008)
- Association of Home Appliance Manufacturers (AHAM), "AHAM method for measuring performance of portable household electric room air cleaners. ANSI", AHAM AC-1-2006; Revision of ANSI, Washington DC, pp.2006, 16~19
- Hinds WC, "Aerosol technology: properties, behaviors, and measurement of airborne particles" (1998), Wiley-Interscience Publication
- Tovey ER, "The distribution of dust mite allergen in the houses of patients with asthma", Am Rev Respir Dis, 124, pp.630~635 (1981)
- de Blay F, "Air borne dust mite allergens: comparison of group II allergens with group I mite allergen and cat-allergen Fel d 1", J Allergy Clin Immunol, 88, pp.919~926 (1991)
- Platts-Mills TAE, "Airborne allergens associated with asthma: particle sizes carrying dust mite and rat allergens measured with a cascade impactor", J Allergy Clin Immunol, 77, pp.850~857 (1986)
- Tovey ER, "Mite faeces are a major source of house dust allergens", Nature, 289, pp.592~593 (1981)
- Vaughan JW, "Evaluation of materials used for bedding encasement: effect of pore size in blocking cat and dust mite allergen", J Allergy Clin Immunol, 103, pp.227~231 (1999)
- Svartengren M, "Deposition of large particles in human lung", Exp Lung Res, 12, pp.75~88 (1987)
- Custovic A, "Dust mite allergens are carried on not only large particles", Pediatr Allergy Immunol, 10, pp.258~260 (1999)
- Ferguson P, "Environmental and bronchoalveolar lavage Dermatophagoides pteronyssinus antigen levels in atopic asthmatics", Am J Respir Crit Care Med, 151, pp.71~74 (1995)
- De Lucca S, "Mite allergen (Der p 1) is not only carried on mite feces", J Allergy Clin Immunol, 103, pp.174~175 (1999)
- Fox RW, "Air cleaners: a review", J Allergy Clin Immunol, 94, pp.413~416 (1994)
- Shaughnessy RJ, "What is an effective portable air cleaning device? A review", J Occup Environ Hyg, 3, pp.169~181 (2006)