공기청정기의 실내공기 질 및 아토피피부염에 대한 영향
Effect of air purifier on indoor air quality and atopic dermatitis
0
조회
0
다운로드
7
인용
0
참고문헌
키워드
초록
Purpose: High level of indoor air pollutant may cause aggravation of atopic diseases long with various allergic respiratory diseases especially in people who spend mostly of their lives indoors. The aim of this study was to evaluate the effect of air purifier on the reduction of relevant hazards in indoors and the improvement of atopic dermatitis (AD). Methods: A total of 24 families, consisted of 18 AD families and 6 normal control families, were enrolled in this study. We examined air quality and AD severity before the installation of air purifiers and after twenty-four weeeks. The assessment of air quality included fine particles (particulate matter, PM2.5 and PM10), gaseous contaminants (CO, CO2, volatile organic compounds [VOCs], formaldehyde, NO2) and density of offloating microorganisms. Severity of AD was assessed by SCORing atopic dermatitis (SCORAD) index and transepidermal water loss (TEWL). Results: At the end of study, particular air pollutants and VOCs of gaseous air pollutants decreased in both groups (P<0.01). In AD group, SCORAD index decreased from 23.45±4.34 to 15.42±6.53 (–18.5%) and TEWL decreased from 33.78±5.16 to 26.89±5.66 (–18.7%) (P<0.01 and P<0.01, respectively). However, the value of total immunoglobulin E and eosinophil did not show significant changes in both groups compared with baseline. Conclusion: These results suggested that air purifier may improve severity of AD by reducing air pollutants like fine particles and VOCs. Our preliminary study could provide a basis for using air purifier to prevent aggravation of AD.
Abstract
Purpose: High level of indoor air pollutant may cause aggravation of atopic diseases long with various allergic respiratory diseases especially in people who spend mostly of their lives indoors. The aim of this study was to evaluate the effect of air purifier on the reduction of relevant hazards in indoors and the improvement of atopic dermatitis (AD). Methods: A total of 24 families, consisted of 18 AD families and 6 normal control families, were enrolled in this study. We examined air quality and AD severity before the installation of air purifiers and after twenty-four weeeks. The assessment of air quality included fine particles (particulate matter, PM2.5 and PM10), gaseous contaminants (CO, CO2, volatile organic compounds [VOCs], formaldehyde, NO2) and density of offloating microorganisms. Severity of AD was assessed by SCORing atopic dermatitis (SCORAD) index and transepidermal water loss (TEWL). Results: At the end of study, particular air pollutants and VOCs of gaseous air pollutants decreased in both groups (P<0.01). In AD group, SCORAD index decreased from 23.45±4.34 to 15.42±6.53 (–18.5%) and TEWL decreased from 33.78±5.16 to 26.89±5.66 (–18.7%) (P<0.01 and P<0.01, respectively). However, the value of total immunoglobulin E and eosinophil did not show significant changes in both groups compared with baseline. Conclusion: These results suggested that air purifier may improve severity of AD by reducing air pollutants like fine particles and VOCs. Our preliminary study could provide a basis for using air purifier to prevent aggravation of AD.
참고문헌 (31)
- Spergel JM, "Epidemiology of atopic dermatitis and atopic march in children", Immunol Allergy Clin North Am, 30, pp.269~280 (2010)
- Choi WJ, "Prevalence and risk factors for atopic dermatitis: a cross-sectional study of 6,453 Korean preschool children", Acta Derm Venereol, 92, pp.467~471 (2012)
- McNally NJ, "Is there a geographical variation in eczema prevalence in the UK? Evidence from the 1958 British Birth Cohort Study", Br J Dermatol, 142, pp.712~720 (2000)
- 박영립, "아토피피부염 학회보고서: 한국인 아토피피부염의 진단기준에 대한 연구", 대한피부과학회지, 44(6), pp.659~663 (2006), 대한피부과학회
- Wen HJ, "Predicting risk for early infantile atopic dermatitis by hereditary and environmental factors", Br J Dermatol, 161, pp.1166~1172 (2009)
- Capristo C, "Environmental prevention in atopic eczema dermatitis syndrome (AEDS) and asthma: avoidance of indoor allergens", Allergy, 59(Suppl 78), pp.53~60 (2004)
- 추상효, "알레르기성 질환 예방을 위한 실내공기질 관리", Allergy Asthma & Respiratory Diseases, 20(2), pp.93~99 (2010), 대한 소아알레르기 호흡기학회
- 김기연, "복합식 공기청정기의 물리적 및 생물학적 입자상 물질의 제거 효과", 한국환경보건학회지, 32(5), pp.478~484 (2006), 한국환경보건학회
- 나경호, "실내용 공기청정기 유형별 실내환경개선 성능에 대한 비교평가", 환경영향평가, 14(3), pp.109~115 (2005), 한국환경영향평가학회
- Reisman RE, "A double-blind study of the effectiveness of a high-efficiency particulate air (HEPA) filter in the treatment of patients with perennial allergic rhinitis and asthma", J Allergy Clin Immunol, 85, pp.1050~1057 (1990)
- Antonicelli L, "Efficacy of an air-cleaning device equipped with a high efficiency particulate air filter in house dust mite respiratory allergy", Allergy, 46, pp.594~600 (1991)
- Warburton CJ, "Domiciliary air filtration units, symptoms and lung function in atopic asthmatics", Respir Med, 88, pp.771~776 (1994)
- Samet JM, "Fine particulate air pollution and mortality in 20 U.S. cities, 1987-1994", N Engl J Med, 343, pp.1742~1749 (2000)
- Oftedal B, "Residential outdoor air pollution and allergen sensitization in schoolchildren in Oslo, Norway", Clin Exp Allergy, 37, pp.1632~1640 (2007)
- Santosh Rani Agrawal, "Effect of an Air Cleaner with Electrostatic Filter on the Removal of Airborne House Dust Mite Allergens", Yonsei Medical Journal, 51(6), pp.918~923 (2010), 연세대학교의과대학
- Okada K, "Systematic cleaning of the mite antigens in home environment and its effects on atopic dermatitis", Nihon Koshu Eisei Zasshi, 41, pp.165~171 (1994)
- Hiramoto K, "Plasma cluster ions decrease the antigenicity of mite allergens and suppress atopic dermatitis in NC", Nga mice, 2011, pp.303, 367~370
- Diez U, "Effects of indoor painting and smoking on airway symptoms in atopy risk children in the first year of life results of the LARS-study. Leipzig Allergy High-Risk Children Study", Int J Hyg Environ Health, 203, pp.23~28 (2000)
- Huss-Marp J, "Influence of short-term exposure to airborne Der p 1 and volatile organic compounds on skin barrier function and dermal blood flow in patients with atopic eczema and healthy individuals", Clin Exp Allergy, 36, pp.338~345 (2006)
- Weisse K, "The LINA cohort: indoor chemical exposure, circulating eosinophil", basophil (Eo, Clin Exp Allergy, pp.2012, 42[DOI]
- Seppanen OA, "Association of ventilation rates and CO2 concentrations with health and other responses in commercial and institutional buildings", Indoor Air, 9, pp.226~252 (1999)
- Eberlein-Konig B, "Influence of airborne nitrogen dioxide or formaldehyde on parameters of skin function and cellular activation in patients with atopic eczema and control subjects", J Allergy Clin Immunol, 101(1 Pt 1), pp.141~143 (1998)
- Monn C, "Personal exposure to nitrogen dioxide in Switzerland. SAPALDIA team. Swiss Study on Air Pollution and Lung Diseases in Adults", Sci Total Environ, 215, pp.243~251 (1998)
- 박현주, "바닥재로부터 방출되는 휘발성유기화합물과 폼알데하이드 특성", 한국대기환경학회지, 25(1), pp.38~45 (2009), 한국대기환경학회
- Hedayati MT, "Specific IgE against Alternaria alternata in atopic dermatitis and asthma patients", Eur Rev Med Pharmacol Sci, 13, pp.187~191 (2009)
- Spiewak R, "Young farmers with cellular reactivity to airborne microbes suffer more frequently from work-related skin symptoms and allergic dermatitis", Ann Agric Environ Med, 8, pp.255~259 (2001)
- Annesi-Maesano I, "Exposure to fine air particles and occurrence of allergic diseases: results of ISAAC-France phase 2", Arch Pediatr, 16, pp.299~305 (2009)
- Song S, "Acute health effects of urban fine and ultrafine particles on children with atopic dermatitis", Environ Res, 111, pp.394~399 (2011)
- Morgan WJ, "Results of a home-based environmental intervention among urban children with asthma", N Engl J Med, 351, pp.1068~1080 (2004)
- 김문범, "아토피피부염에서의 피부관리", 대한피부과학회지, 47(5), pp.531~538 (2009), 대한피부과학회
- 윤성호, "서울지역 한 초등학교의 환경개선과 교육에 의한 아토피피부염 관리 효과", Allergy Asthma & Respiratory Diseases, 21(4), pp.285~293 (2011), 대한 소아알레르기 호흡기학회