Determinants of Bone Mass and Insulin Resistance in Korean Postmenopausal Women: Muscle Area, Strength, or Composition?
2
조회
0
다운로드
2
인용
0
참고문헌
키워드
초록
Purpose: Muscle mass, strength, and composition determine muscle quantity and quality. However, data on muscle propertiesin relation to bone mass or insulin resistance are limited in Asian populations. This study aimed to investigate the relative importanceof muscle measurements in regards to their relationship with lower bone mass and insulin resistance. Materials and Methods: In this study, 192 postmenopausal women (age, 72.39±6.07 years) were enrolled. We measured musclecross-sectional area (CSA) and attenuation at the gluteus maximus and quadriceps muscles through quantitative computed tomography. Muscle strength and physical performance were evaluated with the hand grip test and Short Physical PerformanceBattery (SPPB). Pearson correlation analysis and linear regression were performed to evaluate the relationship between muscleproperties and homeostatic model assessment-insulin resistance (HOMA-IR) or bone mineral density (BMD). Results: Muscle CSA, hand grip strength, and SPPB score held positive correlations with spine and hip BMDs, but not with insulinresistance. In contrast, muscle attenuation of the gluteus maximus or quadriceps was inversely related to HOMA-IR (r=-0.194,p=0.018 and r=-0.292, p<0.001, respectively), but not BMD. Compared with the control group, muscle CSA was significantly decreasedin patients with osteoporosis; however, decreased muscle attenuation, indicating high fat infiltration, was found only inpatients with diabetes. Conclusion: Muscle mass, strength, and physical performance were associated with low bone mass, and accumulation of intramuscularfat, a histological hallmark of persistently damaged muscles, may play a major role in the development of insulin resistancein Korean postmenopausal women.
Abstract
Purpose: Muscle mass, strength, and composition determine muscle quantity and quality. However, data on muscle propertiesin relation to bone mass or insulin resistance are limited in Asian populations. This study aimed to investigate the relative importanceof muscle measurements in regards to their relationship with lower bone mass and insulin resistance. Materials and Methods: In this study, 192 postmenopausal women (age, 72.39±6.07 years) were enrolled. We measured musclecross-sectional area (CSA) and attenuation at the gluteus maximus and quadriceps muscles through quantitative computed tomography. Muscle strength and physical performance were evaluated with the hand grip test and Short Physical PerformanceBattery (SPPB). Pearson correlation analysis and linear regression were performed to evaluate the relationship between muscleproperties and homeostatic model assessment-insulin resistance (HOMA-IR) or bone mineral density (BMD). Results: Muscle CSA, hand grip strength, and SPPB score held positive correlations with spine and hip BMDs, but not with insulinresistance. In contrast, muscle attenuation of the gluteus maximus or quadriceps was inversely related to HOMA-IR (r=-0.194,p=0.018 and r=-0.292, p<0.001, respectively), but not BMD. Compared with the control group, muscle CSA was significantly decreasedin patients with osteoporosis; however, decreased muscle attenuation, indicating high fat infiltration, was found only inpatients with diabetes. Conclusion: Muscle mass, strength, and physical performance were associated with low bone mass, and accumulation of intramuscularfat, a histological hallmark of persistently damaged muscles, may play a major role in the development of insulin resistancein Korean postmenopausal women.
참고문헌 (40)
- Hamrick MW, "The skeletal muscle secretome : an emerging player in muscle-bone crosstalk", Bonekey Rep, 1, pp.60~ (2012)
- Di Monaco M, "Prevalence of sarcopenia and its association with osteoporosis in 313 older women following a hip fracture", Arch Gerontol Geriatr, 52, pp.71~74 (2011)
- DeFronzo RA, "Skeletal muscle insulin resistance is the primary defect in type 2 diabetes", Diabetes Care, 32(Suppl 2), pp.S157~163 (2009)
- Sciorati C, "Cell death, clearance and immunity in the skeletal muscle", Cell Death Differ, 23, pp.927~937 (2016)
- Janssen I, "Evolution of sarcopenia research", Appl Physiol Nutr Metab, 35, pp.707~712 (2010)
- Hughes VA, "Longitudinal muscle strength changes in older adults : influence of muscle mass, physical activity, and health", J Gerontol A Biol Sci Med Sci, 56, pp.B209~17 (2001)
- Barbat-Artigas S, "Muscle quantity is not synonymous with muscle quality", J Am Med Dir Assoc, 14, pp.852~ (2013)
- "ACR-SPR-SSR practive parameter for the performance of musculoskeletal quantitative computed tomography (QCT)"[URL]
- Matthews DR, "Homeostasis model assessment : insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man", Diabetologia, 28, pp.412~419 (1985)
- Adams JE, "Quantitative computed tomography", Eur J Radiol, 71, pp.415~424 (2009)
- Kim KJ, "Aortic calcification and bone metabolism : the relationship between aortic calcification, BMD, vertebral fracture, 25-hydroxyvitamin D, and osteocalcin", Calcif Tissue Int, 91, pp.370~378 (2012)
- Lang TF, "Measurement of bone mineral density at the spine and proximal femur by volumetric quantitative computed tomography and dual-energy X-ray absorptiometry in elderly women with and without vertebral fractures", Bone, 30, pp.247~250 (2002)
- Ochi M, "Quadriceps sarcopenia and visceral obesity are risk factors for postural instability in the middle-aged to elderly population", Geriatr Gerontol Int, 10, pp.233~243 (2010)
- Kim TN, "Body size phenotypes and low muscle mass : the Korean Sarcopenic Obesity Study(KSOS)", J Clin Endocrinol Metab, 98, pp.811~817 (2013)
- 임수, "Ectopic Fat Assessment Focusing on Cardiometabolic and Renal Risk", Endocrinology and Metabolism, 29(1), pp.1~4 (2014), 대한내분비학회
- Watanabe T, "The short-term reliability of grip strength measurement and the effects of posture and grip span", J Hand Surg Am, 30, pp.603~609 (2005)
- Guralnik JM, "A short physical performance battery assessing lower extremity function : association with self-reported disability and prediction of mortality and nursing home admission", J Gerontol, 49, pp.M85~94 (1994)
- WHO Expert Consultation, "Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies", Lancet, 363, pp.157~163 (2004)
- Waist circumference and waist-hip ratio. Report of a WHO Expert Consultation, "WHO Expert Consultation", World Health Organization, ~ (2008)
- Lima RM, "Fat-free mass, strength, and sarcopenia are related to bone mineral density in older women", J Clin Densitom, 12, pp.35~41 (2009)
- Huh JH, "Gender-specific pleiotropic bone-muscle relationship in the elderly from a nationwide survey(KNHANES IV)", Osteoporos Int, 25, pp.1053~1061 (2014)
- Kim JE, "Early-stage chronic kidney disease, insulin resistance, and osteoporosis as risk factors of sarcopenia in aged population : the fourth Korea National Health and Nutrition Examination Survey(KNHANES IV), 2008-2009", Osteoporos Int, 25, pp.2189~2198 (2014)
- Lindsey C, "Association of physical performance measures with bone mineral density in postmenopausal women", Arch Phys Med Rehabil, 86, pp.1102~1107 (2005)
- Blain H, "Influence of muscle strength and body weight and composition on regional bone mineral density in healthy women aged 60years and over", Gerontology, 47, pp.207~212 (2001)
- Lang T, "Computed tomographic measurements of thigh muscle cross-sectional area and attenuation coefficient predict hip fracture : the health, aging, and body composition study", J Bone Miner Res, 25, pp.513~519 (2010)
- Srikanthan P, "Sarcopenia exacerbates obesity-associated insulin resistance and dysglycemia : findings from the National Health and Nutrition Examination Survey III", PLoS One, 5, pp.e10805~ (2010)
- Moon SS, "Low skeletal muscle mass is associated with insulin resistance, diabetes, and metabolic syndrome in the Korean population : the Korea National Health and Nutrition Examination Survey(KNHANES)2009-2010", Endocr J, 61, pp.61~70 (2014)
- Baumgartner RN, "Epidemiology of sarcopenia among the elderly in New Mexico", Am J Epidemiol, 147, pp.755~763 (1998)
- Siu PM, "Aging influences cellular and molecular responses of apoptosis to skeletal muscle unloading", Am J Physiol Cell Physiol, 288, pp.C338~49 (2005)
- Mauro C, "Obesity-induced metabolic stress leads to biased effector memory CD4+ T cell differentiation via PI3K p110δ-Akt-mediated signals", Cell Metab, 25, pp.593~609 (2017)
- Chapman NM, "Dietary fat inflames CD4+ T cell memory in obesity", Cell Metab, 25, pp.490~492 (2017)
- Bruce CR, "Cytokine regulation of skeletal muscle fatty acid metabolism : effect of interleukin-6 and tumor necrosis factor-alpha", Am J Physiol Endocrinol Metab, 287, pp.E616~21 (2004)
- Youd JM, "Acute impairment of insulin-mediated capillary recruitment and glucose uptake in rat skeletal muscle in vivo by TNF-alpha", Diabetes, 49, pp.1904~1909 (2000)
- Debard C, "Expression of key genes of fatty acid oxidation, including adiponectin receptors, in skeletal muscle of Type 2 diabetic patients", Diabetologia, 47, pp.917~925 (2004)
- Araujo AB, "Race", ethnic differences in bone mineral density in men, 2007, pp.18, 943~953
- Kodama K, "Ethnic differences in the relationship between insulin sensitivity and insulin response : a systematic review and meta-analysis", Diabetes Care, 36, pp.1789~1796 (2013)
- Deurenberg P, "Body mass index and percent body fat : a meta analysis among different ethnic groups", Int J Obes Relat Metab Disord, 22, pp.1164~1171 (1998)
- 이상열, "Gender disparity in the secular trends for obesity prevalence in Korea: analyses based on the KNHANES 1998-2009", The Korean Journal of Internal Medicine, 28(1), pp.29~34 (2013), 대한내과학회[DOI]
- Flegal KM, "Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010", JAMA, 307, pp.491~497 (2012)
- Goodpaster BH, "Skeletal muscle attenuation determined by computed tomography is associated with skeletal muscle lipid content", J Appl Physiol(1985), 89, pp.104~110 (2000)
