Correlation of Sarcopenic Obesity on Various Cardiometabolic Risk Factors and Fracture Risk in Mid-Aged Korean Women
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Objectives: This study aimed to investigate the correlation of sarcopenic obesity with various cardiometabolic risk factors and fracture risk in middle-aged Korean women.Methods: In this cross-sectional study, the medical records of 1,775 women who had visited Pusan National University Hospital for routine health screenings from 2010 to 2016 were reviewed. The patients were divided into four groups as follows: group 1, nonsarcopenic, nonobese (NS-NO); group 2, nonsarcopenic, obese (NS-O); group 3, sarcopenic, nonobese (S-NO); and group 4, sarcopenic, obese (S-O). Each patient was assessed based on self-reported questionnaires and individual interviews with a healthcare provider. The Fracture Risk Assessment Tool (FRAX) was used to assess bone fracture risk.Results: Postmenopausal women accounted for 68.5% of the total patient population. The proportion of each group was as follows: NS-NO, 71.2%; NS-O, 17.9%; S-NO, 10.2%; and S-O, 0.7%. Statistical analysis of various parameters associated with metabolic and cardiovascular risks revealed that the S-O group had more patients with hypertension, diabetes, osteopenia, and metabolic syndrome. The FRAX scores were significantly higher in the S-O group than in other groups.Conclusions: Middle-aged women with obesity and reduced muscle mass, known as sarcopenic obesity, are at increased risk of hypertension, diabetes, and metabolic syndrome. Furthermore, sarcopenic obesity, individual cardiometabolic risks, and menopause can increase the bone fracture risk.
Abstract
Objectives: This study aimed to investigate the correlation of sarcopenic obesity with various cardiometabolic risk factors and fracture risk in middle-aged Korean women.Methods: In this cross-sectional study, the medical records of 1,775 women who had visited Pusan National University Hospital for routine health screenings from 2010 to 2016 were reviewed. The patients were divided into four groups as follows: group 1, nonsarcopenic, nonobese (NS-NO); group 2, nonsarcopenic, obese (NS-O); group 3, sarcopenic, nonobese (S-NO); and group 4, sarcopenic, obese (S-O). Each patient was assessed based on self-reported questionnaires and individual interviews with a healthcare provider. The Fracture Risk Assessment Tool (FRAX) was used to assess bone fracture risk.Results: Postmenopausal women accounted for 68.5% of the total patient population. The proportion of each group was as follows: NS-NO, 71.2%; NS-O, 17.9%; S-NO, 10.2%; and S-O, 0.7%. Statistical analysis of various parameters associated with metabolic and cardiovascular risks revealed that the S-O group had more patients with hypertension, diabetes, osteopenia, and metabolic syndrome. The FRAX scores were significantly higher in the S-O group than in other groups.Conclusions: Middle-aged women with obesity and reduced muscle mass, known as sarcopenic obesity, are at increased risk of hypertension, diabetes, and metabolic syndrome. Furthermore, sarcopenic obesity, individual cardiometabolic risks, and menopause can increase the bone fracture risk.
참고문헌 (27)
- Kalyani RR, "Age-related and disease-related muscle loss : the effect of diabetes, obesity, and other diseases", Lancet Diabetes Endocrinol, 2, pp.819~829 (2014)
- Wang M, "Diabetes and sarcopenic obesity: pathogenesis, diagnosis, and treatments", Front Endocrinol (Lausanne), 11, pp.568~ (2020)
- Kyung Mook Choi, "Sarcopenia and sarcopenic obesity", The Korean Journal of Internal Medicine, 31(6), pp.1054~1060 (2016), 대한내과학회[DOI]
- Srikanthan P, "Sarcopenia exacerbates obesity-associated insulin resistance and dysglycemia : findings from the National Health and Nutrition Examination Survey III", PLoS One, 5, pp.e10805~ (2010)
- Hirani V, "Sarcopenia is associated with incident disability, institutionalization, and mortality in community-dwelling older men : the Concord Health and Ageing in Men Project", J Am Med Dir Assoc, 16, pp.607~613 (2015)
- Kim TN, "The implications of sarcopenia and sarcopenic obesity on cardiometabolic disease", J Cell Biochem, 116, pp.1171~1178 (2015)
- Baumgartner RN, "Body composition in healthy aging", Ann N Y Acad Sci, 904, pp.437~448 (2000)
- Farmer RE, "Associations between measures of sarcopenic obesity and risk of cardiovascular disease and mortality : a cohort study and Mendelian randomization analysis using the UK Biobank", J Am Heart Assoc, 8, pp.e011638~ (2019)
- Evans K, "Sarcopenic obesity as a determinant of cardiovascular disease risk in older people : a systematic review", Postgrad Med, 133, pp.831~842 (2021)
- Hong SH, "Sarcopenic obesity, insulin resistance, and their implications in cardiovascular and metabolic consequences", Int J Mol Sci, 21, pp.494~ (2020)
- Follis S, "Association between sarcopenic obesity and falls in a multiethnic cohort of postmenopausal women", J Am Geriatr Soc, 66, pp.2314~2320 (2018)
- Scott D, "Sarcopenic obesity and its temporal associations with changes in bone mineral density, incident falls, and fractures in older men : the Concord Health and Ageing in Men Project", J Bone Miner Res, 32, pp.575~583 (2017)
- Razmjou S, "Body composition, cardiometabolic risk factors, physical activity, and inflammatory markers in premenopausal women after a 10-year follow-up : a MONET study", Menopause, 25, pp.89~97 (2018)
- Zandoná J, "Early decrease in lean mass and bone mass in postmenopausal women : a cross-sectional study", Climacteric, 25, pp.96~102 (2022)
- Chen LK, "Asian Working Group for Sarcopenia : 2019 consensus update on sarcopenia diagnosis and treatment", J Am Med Dir Assoc, 21, pp.300~307 (2020)
- Korean Society of Menopause, "Guidelines for Osteoporosis" (2022), Koonja Publishing Inc
- Roa-Díaz ZM, "Menopause and cardiometabolic diseases : what we(don’t)know and why it matters", Maturitas, 152, pp.48~56 (2021)
- Nappi RE, "Menopause : a cardiometabolic transition", Lancet Diabetes Endocrinol, 10, pp.442~456 (2022)
- 최경묵, "Sarcopenia and Sarcopenic Obesity", Endocrinology and Metabolism, 28(2), pp.86~89 (2013), 대한내분비학회
- Ma J, "Mid-adulthood cardiometabolic risk factor profiles of sarcopenic obesity", Obesity(Silver Spring), 24, pp.526~534 (2016)
- Chung JH, "Association between sarcopenic obesity and bone mineral density in middle-aged and elderly Korean", Ann Nutr Metab, 68, pp.77~84 (2016)
- Hwang J, "Gender-specific prevalence and risk factors of sarcopenic obesity in the Korean elderly population : a nationwide cross-sectional study", Int J Environ Res Public Health, 20, pp.1140~ (2023)
- Cauley JA, "An overview of sarcopenic obesity", J Clin Densitom, 18, pp.499~505 (2015)
- Kim TN, "Prevalence of sarcopenia and sarcopenic obesity in Korean adults : the Korean sarcopenic obesity study", Int J Obes(Lond), 33, pp.885~892 (2009)
- Shieh A, "Estradiol and follicle-stimulating hormone as predictors of onset of menopause transition-related bone loss in pre-and perimenopausal women", J Bone Miner Res, 34, pp.2246~2253 (2019)
- Huo YR, "Phenotype of sarcopenic obesity in older individuals with a history of falling", Arch Gerontol Geriatr, 65, pp.255~259 (2016)
- Chen H, "Sarcopenic obesity defined by visceral adiposity was associated with osteoporotic vertebral fracture", Arch Osteoporos, 17, pp.41~ (2022)