Bone Mineral Density and Fatty Degeneration of Thigh Muscles Measured by Computed Tomography in Hip Fracture Patients
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Background: Recently, as an independent fracture factor from Bone mineral density (BMD), muscle weakness due to the fatty degeneration of thigh muscles have been attracting attentions as causes of hip fracture. The purpose of this study is to investigate the correlation between the body composition and BMD and fatty degeneration of thigh muscles of the female patients over 65 years old with osteoporotic hip fracture. Methods: This study was conducted with 178 female osteoporotic hip fracture patients. Total hip BMD was measured using dual energy X-ray absorptiometry. Cross-sectional area (CSA), cross-sectional muscle area (CSmA), muscle attenuation coefficient (MAC), and intramuscular adipose tissue (IMAT) of gluteus maximus, hip abductors, quadriceps and hamstring muscle were measured with computed tomography. Normalized IMAT (nI- MAT) was calculated by dividing the fat area in the muscle into the size of each muscle. The correlation between each measurement is examined then the differences between the intertrochanteric fracture group and the femoral neck fracture group were analyzed. Results: CSmA and MAC of quadriceps were the largest and nIMAT was the lowest. CSA and CSmA of the four muscles showed a statistically significant positive correlation with weight, height, body mass index (BMI), and BMD. MAC of 2 gluteal muscles was positively correlated with weight, BMI and BMD. nIMAT of all four muscles was positively correlation with weight and BMI but nIMAT of 2 mid-thigh muscles was positively correlation with BMD. Conclusions: Muscle size and fatty degeneration in the thigh muscles were most positively correlated with the body weight. BMD was positively correlation with CSA and CSmA of all thigh muscles, and MAC of 2 gluteal muscles and fatty degeneration of 2 mid-thigh muscles. There was no statistically significant difference in the size of the femoral muscle and the degree of fatty degeneration between the two fracture groups.
Abstract
Background: Recently, as an independent fracture factor from Bone mineral density (BMD), muscle weakness due to the fatty degeneration of thigh muscles have been attracting attentions as causes of hip fracture. The purpose of this study is to investigate the correlation between the body composition and BMD and fatty degeneration of thigh muscles of the female patients over 65 years old with osteoporotic hip fracture. Methods: This study was conducted with 178 female osteoporotic hip fracture patients. Total hip BMD was measured using dual energy X-ray absorptiometry. Cross-sectional area (CSA), cross-sectional muscle area (CSmA), muscle attenuation coefficient (MAC), and intramuscular adipose tissue (IMAT) of gluteus maximus, hip abductors, quadriceps and hamstring muscle were measured with computed tomography. Normalized IMAT (nI- MAT) was calculated by dividing the fat area in the muscle into the size of each muscle. The correlation between each measurement is examined then the differences between the intertrochanteric fracture group and the femoral neck fracture group were analyzed. Results: CSmA and MAC of quadriceps were the largest and nIMAT was the lowest. CSA and CSmA of the four muscles showed a statistically significant positive correlation with weight, height, body mass index (BMI), and BMD. MAC of 2 gluteal muscles was positively correlated with weight, BMI and BMD. nIMAT of all four muscles was positively correlation with weight and BMI but nIMAT of 2 mid-thigh muscles was positively correlation with BMD. Conclusions: Muscle size and fatty degeneration in the thigh muscles were most positively correlated with the body weight. BMD was positively correlation with CSA and CSmA of all thigh muscles, and MAC of 2 gluteal muscles and fatty degeneration of 2 mid-thigh muscles. There was no statistically significant difference in the size of the femoral muscle and the degree of fatty degeneration between the two fracture groups.
참고문헌 (27)
- Edwards MH, "Osteoporosis and sarcopenia in older age", Bone, 80, pp.126~130 (2015)
- Tarantino U, "Osteoporosis and sarcopenia: the connections", Aging Clin Exp Res, 25(Suppl 1), pp.S93~S95 (2013)
- He H, "Relationship of sarcopenia and body composition with osteoporosis", Osteoporos Int, 27, pp.473~482 (2016)
- 김선영, "The Association between the Low Muscle Mass and Osteoporosis in Elderly Korean People", Journal of Korean Medical Science, 29(7), pp.995~1000 (2014), 대한의학회
- Marcus RL, "Intramuscular adipose tissue, sarcopenia, and mobility function in older individuals", J Aging Res, 2012, pp.629637~ (2012)
- 윤현구, "Incidence and Mortality Following Hip Fracture in Korea", Journal of Korean Medical Science, 26(8), pp.1087~1092 (2011), 대한의학회
- Yoon BH, "Epidemiology of proximal femoral fractures in South Korea", Arch Osteoporos, 8, pp.157~ (2013)
- Svejme O, "Low BMD is an independent predictor of fracture and early menopause of mortality in post-menopausal women--a 34-year prospective study", Maturitas, 74, pp.341~345 (2013)
- Broy SB, "Fracture risk prediction by non-BMD DXA measures : the 2015 ISCD official positions part 1 : hip geometry", J Clin Densitom, 18, pp.287~308 (2015)
- Schafer AL, "Fat infiltration of muscle, diabetes, and clinical fracture risk in older adults", J Clin Endocrinol Metab, 95, pp.E368~E372 (2010)
- Malkov S, "Hip fractures risk in older men and women associated with DXA-derived measures of thigh subcutaneous fat thickness, cross-sectional muscle area, and muscle density", J Bone Miner Res, 30, pp.1414~1421 (2015)
- Visser M, "Muscle mass, muscle strength, and muscle fat infiltration as predictors of incident mobility limitations in well-functioning older persons", J Gerontol A Biol Sci Med Sci, 60, pp.324~333 (2005)
- Visser M, "Leg muscle mass and composition in relation to lower extremity performance in men and women aged 70 to 79: the health, aging and body composition study", J Am Geriatr Soc, 50, pp.897~904 (2002)
- Moreland JD, "Muscle weakness and falls in older adults : a systematic review and meta-analysis", J Am Geriatr Soc, 52, pp.1121~1129 (2004)
- Lang T, "Computed tomographic measurements of thigh muscle cross-sectional area and attenuation coefficient predict hip fracture: the health, aging, and body composition study", J Bone Miner Res, 25, pp.513~519 (2010)
- Goodpaster BH, "Composition of skeletal muscle evaluated with computed tomography", Ann N Y Acad Sci, 904, pp.18~24 (2000)
- Bouche KG, "Computed tomographic analysis of the quality of trunk muscles in asymptomatic and symptomatic lumbar discectomy patients", BMC Musculoskelet Disord, 12, pp.65~ (2011)
- Bonewald LF, "Forum on bone and skeletal muscle interactions : summary of the proceedings of an ASBMR workshop", J Bone Miner Res, 28, pp.1857~1865 (2013)
- Goodpaster BH, "The loss of skeletal muscle strength, mass, and quality in older adults: the health, aging and body composition study", J Gerontol A Biol Sci Med Sci, 61, pp.1059~1064 (2006)
- Goodpaster BH, "Attenuation of skeletal muscle and strength in the elderly : The Health ABC Study", J Appl Physiol, 90, pp.2157~2165 (2001)
- Marcus RL, "Skeletal muscle fat infiltration: impact of age, inactivity, and exercise", J Nutr Health Aging, 14, pp.362~366 (2010)
- Nakagawa Y, "Age-related changes in intramyocellular lipid in humans by in vivo H-MR spectroscopy", Gerontology, 53, pp.218~223 (2007)
- Goodpaster BH, "Skeletal muscle attenuation determined by computed tomography is associated with skeletal muscle lipid content", J Appl Physiol, 89, pp.104~110 (2000)
- Inacio M, "Gluteal muscle composition differentiates fallers from non-fallers in community dwelling older adults", BMC Geriatr, 14, pp.37~ (2014)
- Thelen DG, "Muscle activities used by young and old adults when stepping to regain balance during a forward fall", J Electromyogr Kinesiol, 10, pp.93~101 (2000)
- Lang T, "Pelvic body composition measurements by quantitative computed tomography : association with recent hip fracture", Bone, 42, pp.798~805 (2008)
- Park SW, "Excessive loss of skeletal muscle mass in older adults with type 2 diabetes", Diabetes Care, 32, pp.1993~1997 (2009)