Vitamin D supplementation for primary dysmenorrhea: a double-blind, randomized, placebo-controlled trial
2
조회
0
다운로드
2
인용
0
참고문헌
키워드
초록
ObjectiveRecent studies have shown a possible association between vitamin D deficiency and the severity of primarydysmenorrhea. The present study aimed to investigate the effect of vitamin D supplementation on pain and systemicsymptoms in patients with primary dysmenorrhea. MethodsThis double-blind, randomized, placebo-controlled trial was conducted on female students aged 18 to 32 years withprimary dysmenorrhea and vitamin D deficiency (25 [OH]D <30 ng/mL). The participants (n=116) received either 50,000 IUof vitamin D3 (cholecalciferol) or placebo capsules on a weekly basis for eight consecutive weeks. The outcomes werepain intensity (scored 0 to 10), number of days with pain, number of consumed pain-relief medications (per day), andseverity of systemic symptoms (fatigue, headache, nausea/vomiting, and diarrhea; total score of 0 to 12). ResultsCompared with baseline, our participants who received vitamin D experienced significant reductions in pain intensity(-1.0 and -1.5 score at weeks 4 and 8, P<0.001), the number of days with pain (-1.0 day at weeks 4 and 8, P<0.001), thenumber of consumed pain-relief medications (-1.0 at weeks 4 and 8, P<0.001), and systemic symptoms severity (-1.0 scoreat weeks 4 and 8, P<0.001). No significant improvements were observed in the placebo group in terms of these outcomes. ConclusionVitamin D supplementation in women with primary dysmenorrhea and vitamin D deficiency could improve systemicsymptoms and reduce pain intensity, the number of days with pain, and the need for consuming pain-relief medications.
Abstract
ObjectiveRecent studies have shown a possible association between vitamin D deficiency and the severity of primarydysmenorrhea. The present study aimed to investigate the effect of vitamin D supplementation on pain and systemicsymptoms in patients with primary dysmenorrhea. MethodsThis double-blind, randomized, placebo-controlled trial was conducted on female students aged 18 to 32 years withprimary dysmenorrhea and vitamin D deficiency (25 [OH]D <30 ng/mL). The participants (n=116) received either 50,000 IUof vitamin D3 (cholecalciferol) or placebo capsules on a weekly basis for eight consecutive weeks. The outcomes werepain intensity (scored 0 to 10), number of days with pain, number of consumed pain-relief medications (per day), andseverity of systemic symptoms (fatigue, headache, nausea/vomiting, and diarrhea; total score of 0 to 12). ResultsCompared with baseline, our participants who received vitamin D experienced significant reductions in pain intensity(-1.0 and -1.5 score at weeks 4 and 8, P<0.001), the number of days with pain (-1.0 day at weeks 4 and 8, P<0.001), thenumber of consumed pain-relief medications (-1.0 at weeks 4 and 8, P<0.001), and systemic symptoms severity (-1.0 scoreat weeks 4 and 8, P<0.001). No significant improvements were observed in the placebo group in terms of these outcomes. ConclusionVitamin D supplementation in women with primary dysmenorrhea and vitamin D deficiency could improve systemicsymptoms and reduce pain intensity, the number of days with pain, and the need for consuming pain-relief medications.
참고문헌 (40)
- "ACOG Committee Opinion No. 760: Dysmenorrhea and endometriosis in the adolescent", Obstet Gynecol, 132, pp.e249~e258 (2018)
- Iacovides S, "What we know about primary dysmenorrhea today : a critical review", Hum Reprod Update, 21, pp.762~778 (2015)
- Proctor M, "Diagnosis and management of dysmenorrhoea", BMJ, 332, pp.1134~1138 (2006)
- Juang CM, "Impact of pregnancy on primary dysmenorrhea", Int J Gynaecol Obstet, 92, pp.221~227 (2006)
- Ju H, "The prevalence and risk factors of dysmenorrhea", Epidemiol Rev, 36, pp.104~113 (2014)
- Kharaghani R, "The prevalence of dysmenorrhea in Iran: a systematic review and meta-analysis", Iran Red Crescent Med J, 19, pp.e40856~ (2017)
- De Sanctis V, "Dysmenorrhea in adolescents and young adults : a review in different countries", Acta Biomed, 87, pp.233~246 (2016)
- Sultan C, "Adolescent dysmenorrhea", Endocr Dev, 22, pp.171~180 (2012)
- Doty E, "Managing primary dysmenorrhea", J Pediatr Adolesc Gynecol, 19, pp.341~344 (2006)
- Berek JS, "Berek & Novak's gynecology" (2019), Lippincott Williams & Wilkins
- Guimarães I, "Primary dysmenorrhea : assessment and treatment", Rev Bras Ginecol Obstet, 42, pp.501~507 (2020)
- Zahradnik HP, "Nonsteroidal anti-inflammatory drugs and hormonal contraceptives for pain relief from dysmenorrhea : a review", Contraception, 81, pp.185~196 (2020)
- Firestein GS, "Kelley´s textbook of rheumatology" (2009), Saunders Elsevier
- Pramanik P, "Primary dysmenorrhea in school going adolescent girls-is it related to deficiency of antioxidant in diet?", Int J Life Sci Phar Res, 5, pp.54~63 (2015)
- Charandabi SMA, "Effect of calcium with and without magnesium on amount and duration of menstrual bleeding in students with primary dysmenorrhea", Iran J Obestet Gynecol Infertil, 16, pp.1~8 (2013)
- Fatemeh Abdi, "A systematic review of the role of vitamin D and calcium in premenstrual syndrome", Obstetrics & Gynecology Science, 62(2), pp.73~86 (2019), 대한산부인과학회
- Fatemeh Abdi, "Role of vitamin D and calcium in the relief of primary dysmenorrhea: a systematic review", Obstetrics & Gynecology Science, 64(1), pp.13~26 (2021), 대한산부인과학회[DOI]
- Thota C, "Vitamin D regulates contractile profile in human uterine myometrial cells via NF-κB pathway", Am J Obstet Gynecol, 210, pp.347.e1~347.e10 (2014)
- Viganò P, "Cycling and early pregnant endometrium as a site of regulated expression of the vitamin D system", J Mol Endocrinol, 36, pp.415~424 (2006)
- Kucukceran H, "The impact of circulating 25-hydroxyvitamin and oral cholecalciferol treatment on menstrual pain in dysmenorrheic patients", Gynecol Endocrinol, 35, pp.53~57 (2019)
- Lasco A, "Improvement of primary dysmenorrhea caused by a single oral dose of vitamin D: results of a randomized, double-blind, placebocontrolled study", Arch Intern Med, 172, pp.366~367 (2012)
- Zangene M, "Evaluation of the effects of oral vitamin-D for pelvic pain reduction in primary dysmenorrhea", Iran J Obstet Gynecol Infertil, 88, pp.14~20 (2014)
- Moini A, "The effect of vitamin D on primary dysmenorrhea with vitamin D deficiency : a randomized double-blind controlled clinical trial", Gynecol Endocrinol, 32, pp.502~505 (2016)
- Ayşegül Ö, "A randomized controlled study of vitamin D in the treatment of primary dysmenorrhea", Duzce Med J, 21, pp.32~36 (2019)
- Vatandost S, "Prevalence of vitamin D deficiency in Iran : a systematic review and meta-analysis", Nutr Health, 24, pp.269~278 (2018)
- Holick MF, "Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline", J Clin Endocrinol Metab, 96, pp.1911~1930 (2011)
- Beller EM, "Randomisation in clinical trials", Med J Aust, 177, pp.565~567 (2002)
- Hodges JL Jr, "Estimates of location based on rank tests", Ann Math Stat, 34, pp.598~611 (1963)
- Holm S, "A simple sequentially rejective multiple test procedure", Scand J Statist, 6, pp.65~70 (1979)
- Abdul-Razzak KK, "Influence of dietary intake of dairy products on dysmenorrhea", J Obstet Gynaecol Res, 36, pp.377~383 (2010)
- Abdul-Razzak KK, "Vitamin D and PTH status among adolescent and young females with severe dysmenorrhea", J Pediatr Adolesc Gynecol, 27, pp.78~82 (2014)
- Holick MF, "Vitamin D deficiency", N Engl J Med, 357, pp.266~281 (2007)
- Adams JS, "Extrarenal expression of the 25-hydroxyvitamin D-1-hydroxylase", Arch Biochem Biophys, 523, pp.95~102 (2012)
- Abbasi ST, "Serum magnesium and 25-hydroxy cholecalciferol in premenstrual syndrome during luteal phase", J Liaquat Uni Med Health Sci, 16, pp.209~212 (2017)
- Holick MF, "Guidelines for preventing and treating vitamin D deficiency and insufficiency revisited", J Clin Endocrinol Metab, 97, pp.1153~1158 (2012)
- Fassio A, "Pharmacokinetics of oral cholecalciferol in healthy subjects with vitamin d deficiency : a randomized open-label study", Nutrients, 12, pp.1553~ (2020)
- Toth BE, "Safety and efficacy of weekly 30,000 IU vitamin D supplementation as a slower loading dose administration compared to a daily maintenance schedule in deficient patients: a randomized", Contr Clin Trial J Pharmacovigil, 5, pp.2~ (2017)
- Kearns MD, "Large, single-dose, oral vitamin D supplementation in adult populations: a systematic review", Endocr Pract, 20, pp.341~351 (2014)
- Karacin O, "Serum vitamin D concentrations in young Turkish women with primary dysmenorrhea : a randomized controlled study", Taiwan J Obstet Gynecol, 57, pp.58~63 (2018)
- Thys-Jacobs S, "Cyclical changes in calcium metabolism across the menstrual cycle in women with premenstrual dysphoric disorder", J Clin Endocrinol Metab, 92, pp.2952~2959 (2007)