Comparison of the effect of vitamin E, vitamin D and ginger on the severity of primary dysmenorrhea: a single-blind clinical trial
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ObjectiveDysmenorrhea is one of the most common problems for women, especially during their reproductive age. Variousstudies have examined the effects of vitamins D and E and ginger supplements. This study aimed to investigate theindividual effects of each of these supplements on dysmenorrhea. MethodsThis single-blind clinical trial was conducted in 2016 on students aged 18 to 25 years who complained of mild to severedysmenorrhea. The participants were randomly assigned into 4 groups: vitamin D, vitamin E, ginger, and placebo. The effects of the supplements on the severity of dysmenorrhea were evaluated in 2 successive cycles using the visualanalog scale (VAS) and a questionnaire. ResultsInitially, 240 female students were enrolled in the study; thereafter, 40 students were excluded from the study owingto follow-up loss. The average VAS score for dysmenorrhea in the entire study population was 7.13±0.80 before theintervention; the mean VAS score after the first and second months of supplement use was 5.37±1.51 and 4.93±1.48,respectively. The highest reduction in pain severity was observed in the ginger group (F=74.54, P<0.001). ConclusionVitamin D, vitamin E, and ginger significantly reduced the severity of dysmenorrhea, with ginger having the mostsignificant effect followed by vitamin D and vitamin E. Given the low risk of these supplements, more studies must beconducted on their use as opposed to analgesics.
Abstract
ObjectiveDysmenorrhea is one of the most common problems for women, especially during their reproductive age. Variousstudies have examined the effects of vitamins D and E and ginger supplements. This study aimed to investigate theindividual effects of each of these supplements on dysmenorrhea. MethodsThis single-blind clinical trial was conducted in 2016 on students aged 18 to 25 years who complained of mild to severedysmenorrhea. The participants were randomly assigned into 4 groups: vitamin D, vitamin E, ginger, and placebo. The effects of the supplements on the severity of dysmenorrhea were evaluated in 2 successive cycles using the visualanalog scale (VAS) and a questionnaire. ResultsInitially, 240 female students were enrolled in the study; thereafter, 40 students were excluded from the study owingto follow-up loss. The average VAS score for dysmenorrhea in the entire study population was 7.13±0.80 before theintervention; the mean VAS score after the first and second months of supplement use was 5.37±1.51 and 4.93±1.48,respectively. The highest reduction in pain severity was observed in the ginger group (F=74.54, P<0.001). ConclusionVitamin D, vitamin E, and ginger significantly reduced the severity of dysmenorrhea, with ginger having the mostsignificant effect followed by vitamin D and vitamin E. Given the low risk of these supplements, more studies must beconducted on their use as opposed to analgesics.
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