한국의 아토피피부염 환자에서 혼합생약추출물 함유 로션의 효능에 대한 예비연구
he Effect of the Mixed Herbal Extract Lotion for Korean Patient with Atopic Dermatitis: A Pilot Study
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Background: The choice of topical agents is very important for patients with atopic dermatitis (AD) because mild to moderate AD-related symptoms and skin lesions could be significantly relieved with appropriate topical treatment. This study was performed to evaluate the effectineness of a mixed herbal extract lotion containing the extract of Sophorae Radix, Cinnamomi Cortex, Saururi Herba Seu Rhizoma and Aurantii Immaturus Fructus in relieving symptoms and skin lesions associated with AD. Methods: A total of 24 patients who were suffering mild to moderate AD applied topical lotions, i.e. the test lotion on the right antecubital fossa and the control lotion on the left antecubital fossa twice daily for up to 4 weeks. The treatment efficacy was evaluated by the measurement of skin hydration and trans-epidermal water loss (TEWL) on the same site at each visit. Additional evaluation methods were the investigator global assessment (IGA) and the visual analogue scale visual analogue scale for pruritus. Results: The test lotion-applied right antecubital fossa achieved more clinical improvement than the control lotion-applied left antecubital fossa. TEWL on the test side more significantly decreased than that on the control side after 4 weeks of lotion application. There were slightly more improvements in both the IGA and patient assessment of pruritus on the test side. Conclusion: Mixed herbal extract lotions containing the extracts of Sophorae Radix, Cinnamomi Cortex, Saururi Herba Seu Rhizoma and Aurantii Immaturus Fructus can relieve symptoms, such as pruritus, in AD patients.
Abstract
Background: The choice of topical agents is very important for patients with atopic dermatitis (AD) because mild to moderate AD-related symptoms and skin lesions could be significantly relieved with appropriate topical treatment. This study was performed to evaluate the effectineness of a mixed herbal extract lotion containing the extract of Sophorae Radix, Cinnamomi Cortex, Saururi Herba Seu Rhizoma and Aurantii Immaturus Fructus in relieving symptoms and skin lesions associated with AD. Methods: A total of 24 patients who were suffering mild to moderate AD applied topical lotions, i.e. the test lotion on the right antecubital fossa and the control lotion on the left antecubital fossa twice daily for up to 4 weeks. The treatment efficacy was evaluated by the measurement of skin hydration and trans-epidermal water loss (TEWL) on the same site at each visit. Additional evaluation methods were the investigator global assessment (IGA) and the visual analogue scale visual analogue scale for pruritus. Results: The test lotion-applied right antecubital fossa achieved more clinical improvement than the control lotion-applied left antecubital fossa. TEWL on the test side more significantly decreased than that on the control side after 4 weeks of lotion application. There were slightly more improvements in both the IGA and patient assessment of pruritus on the test side. Conclusion: Mixed herbal extract lotions containing the extracts of Sophorae Radix, Cinnamomi Cortex, Saururi Herba Seu Rhizoma and Aurantii Immaturus Fructus can relieve symptoms, such as pruritus, in AD patients.
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