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복분자의 항산화 및 광독성 억제활성에 미치는 영향

The Effects of Anti-Oxidant and Phototoxic Inhibitory Activity of Rubus coreanus Fruits

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Objectives : Oxidation by active oxygen in the body, phototoxicity and photoallergic interest has grown,antioxidant and phototoxicity inhibiting substances for research progress. The purpose of this study was toexamine the effects on antioxidant and phototoxicity of Rubus coreanus Fruits. Meterial and Methods : Hs68 cell lines using the DPPH radical scavenging activity, cytotoxic, phototoxicinhibitory activity and apoptosis were measured. Results : 1. In MTT assay, the concentrations of Rubus coreanus Fruits that were used on the test had nocytotoxicity. 2. In DPPH radical scavenging activity, the concentration of 50 ㎍/㎖, 100 ㎍/㎖ anti-oxidant effect ofRubus coreanus Fruits was statistically significant increased than control group in dose-dependantly. 3. In phototoxic inhibitory activity, Rubus coreanus Fruits dose-dependently increased the cell viabilityof Hs68 cell lines. 4. The concentration of 50 ㎍/㎖ Rubus coreanus Fruits inhibited the enrichment of nucleus in theHs68 cell stimulated with UVB. Conclusions : These results indicate that Rubus coreanus Fruits has anti-oxidant effects and Phototoxic InhibitoryActivity. If further study is performed, the use of Rubus coreanus Fruits will be valuable andbeneficial in the therapy of skin aging and damage.

Abstract

Objectives : Oxidation by active oxygen in the body, phototoxicity and photoallergic interest has grown,antioxidant and phototoxicity inhibiting substances for research progress. The purpose of this study was toexamine the effects on antioxidant and phototoxicity of Rubus coreanus Fruits. Meterial and Methods : Hs68 cell lines using the DPPH radical scavenging activity, cytotoxic, phototoxicinhibitory activity and apoptosis were measured. Results : 1. In MTT assay, the concentrations of Rubus coreanus Fruits that were used on the test had nocytotoxicity. 2. In DPPH radical scavenging activity, the concentration of 50 ㎍/㎖, 100 ㎍/㎖ anti-oxidant effect ofRubus coreanus Fruits was statistically significant increased than control group in dose-dependantly. 3. In phototoxic inhibitory activity, Rubus coreanus Fruits dose-dependently increased the cell viabilityof Hs68 cell lines. 4. The concentration of 50 ㎍/㎖ Rubus coreanus Fruits inhibited the enrichment of nucleus in theHs68 cell stimulated with UVB. Conclusions : These results indicate that Rubus coreanus Fruits has anti-oxidant effects and Phototoxic InhibitoryActivity. If further study is performed, the use of Rubus coreanus Fruits will be valuable andbeneficial in the therapy of skin aging and damage.

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