급성인두염의 한약 치료에 대한 체계적 문헌 고찰 및 메타분석 : 중국 논문을 중심으로
A Systemic Review and Meta-Analysis of Herbal Medicine Treatment for Acute Pharyngitis : Based on Chinese Articles
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Objectives : The purpose of this study is to investigate the effectiveness and safety of herbal medicine treatment for acute pharyngitis. Methods : 2 databases(Wangfang Med Online, CNKI) were used to search Randomized Controlled Trials(RCTs) that used herbal medicine treatment for acute pharyngitis, which were published from January 2007 until April 2024. Results : 9 RCTs were selected in this study, and all studies compared herbal medicine alone treatment with western medicine alone treatment. The most frequently used medicine was Toxin-removing medicinal(淸熱解毒 藥). Platycodonis Radix(桔梗) was the most frequently used herb. Meta-analysis of nine studies showed that the Total Effective Rate(TER) of treatment group was statistically higher than that of control group(RR:1.12, 95% CI:1.06 to 1.19, p<0.00001, I2=22%). Meta-analysis of 3 studies showed that the total symptom score of treatment group statistically improved than that of control group(MD: -1.00, 95% CI: -1.30 to –0.71, p<0.00001, I2=0%). Mild adverse events such as anorexia were identified in 4 RCTs, but no serious adverse events were reported. Conclusion : Using herbal medicine alone can be more effective and safe in improving acute pharyngitis than using western medicine. But further well-designed studies are needed because heterogeneity between studies existed and the quality of the reports needs to be improved.
Abstract
Objectives : The purpose of this study is to investigate the effectiveness and safety of herbal medicine treatment for acute pharyngitis. Methods : 2 databases(Wangfang Med Online, CNKI) were used to search Randomized Controlled Trials(RCTs) that used herbal medicine treatment for acute pharyngitis, which were published from January 2007 until April 2024. Results : 9 RCTs were selected in this study, and all studies compared herbal medicine alone treatment with western medicine alone treatment. The most frequently used medicine was Toxin-removing medicinal(淸熱解毒 藥). Platycodonis Radix(桔梗) was the most frequently used herb. Meta-analysis of nine studies showed that the Total Effective Rate(TER) of treatment group was statistically higher than that of control group(RR:1.12, 95% CI:1.06 to 1.19, p<0.00001, I2=22%). Meta-analysis of 3 studies showed that the total symptom score of treatment group statistically improved than that of control group(MD: -1.00, 95% CI: -1.30 to –0.71, p<0.00001, I2=0%). Mild adverse events such as anorexia were identified in 4 RCTs, but no serious adverse events were reported. Conclusion : Using herbal medicine alone can be more effective and safe in improving acute pharyngitis than using western medicine. But further well-designed studies are needed because heterogeneity between studies existed and the quality of the reports needs to be improved.
참고문헌 (29)
- The Society of Korean Medicine Ophthalmology, Otolaryngology & Dermatology, "Korean Medicine of Ophthalmology & Otolaryngology", pp.221~222 (2019), Globooks
- Park MK, "Otology, Rhinology and Laryngology", pp.353~354 (1996), Ilchogak
- Gerber MA, "Diagnosis and Treatment of Pharyngitis in Children. Peditr", Clin North Am, 52(3), pp.729~747 (2005)
- Robertson KA, "Antibiotics for the Primary Prevention of Acute Rheumatic Fever : a meta-analysis", BMC Cardiovasc Disord, 5(1), pp.11~ (2005)
- Cots JM, "Recommendations for Management of Acute Pharyngitis in Adults", Acta Otorrinolaringologica(English Edition), 66(3), pp.159~170 (2015)
- Zhu S, "Clinical Observation on the Treatment of Acute Pharyngitis(Wind Heat Syndrome)with Shufeng Jiedu Capsule Combined with Budesonide Atomization", Zhongyiyaoyanjiu, 16(8), pp.67~71 (2019)
- Mayes T, "Are Follow-up Cultures Necessary when Rapid Antigen Detection Tests are Negative for Group A Streptococci", Clin Peditr, 40(4), pp.191~195 (2001)
- Robert M, "Nelson Textbook of Pediatrics", pp.2558~2562 (2024), Elsevier
- Kang JG, "A Systematic Review on the Effectiveness of Acupuncture Treatment for Acute Pharyngitis", J Korean Med Ophthalmol Otolaryngol Dermatol, pp.1~38 (2018)
- Yin Q, "Clinical Verification of Cheongin-tang in Treating Acute Pharyngitis", Medical Journal of Chinese People's Health, 19(6), pp.451~ (2007)
- Pan Z, "Clinical Observation on Treating Acute Pharyngitis with Yukmi-tang", Guide of China Medicine, 8(22), pp.125~ (2010)
- Liu W, "68 Cases of Acute Pharyngitis treated with Yukmi-tang", Heibei J TCM, 34(7), pp.1003~ (2012)
- Jang J, "Observation on the Efficacy of Eungyo-san Flavored in the Treatment of 45 Cases of Acute Pharyngitis", Yunnan Journal of Traditional Chinese Medicine, 33(8), pp.44~ (2012)
- Wang Y, "Observation on the Clinical Efficacy of Gyoha-tang in the Treatment of Acute Pharyngitis", Chinese Medical Frontier, 8(16), pp.124~ (2013)
- Zhong W, "Clinical Observation on 60 Cases of Acute Pharyngitis(Wind-heat Syndrome)Treated by Chaiqinliyan Decoction", China Health Care & Nutrition, 2(2), pp.329~ (2016)
- Guo X, "33 cases of Acute Pharyngitis treated with Cheonginchisi-tang", Henan Traditional Chinese Medicine, 37(6), pp.1038~1040 (2017)
- Li J, "Observation on the Clinical Efficacy of Cheonginhadam-tang in the Treatment of 60 cases of Acute Pharyngitis", Cardiovascular Disease Journal of Integrated Traditional Chinese and Western Medicine, 5(28), pp.177~ (2017)
- Zhou Y, "Therapeutic Effect of Daecheongin-tang on Acute Pharyngitis of Exogenous Wind-heat Type", Traditional Chinese Medicine, 17, pp.104~ (2019)
- Roh SS, "Kyojeong Wonsek Otolaryngology", pp.47~ (1999), Iljoongsa
- Goossens H, "Outpatient antibiotic use in Europe and association with resistance : Across-national database study", Lancet, 365(9459), pp.579~587 (2005)
- Duin DV, "Multidrug-resistant bacteria in the community : an update", Infectious Disease Clinics, 34(4), pp.709~722 (2020)
- Martens E, "The antibiotic resistance crisis, with a focus on the United States", The Journal of antibiotics, 70(5), pp.520~526 (2017)
- Larson E, "Community factors in the development of antibiotic resistance. Annu. Rev", Public Health, 28, pp.435~447 (2007)
- Kim IR, "Bonchohak", pp.158~585 (2011), Young Lim Publishing Co
- Han EH, "Inhibitory mechanism of saponins deri ved from roots of Platycodon grandiflorum on anaphylactic reaction and IgE-mediated allergic response in mast cells", Food Chem Toxicol, 47(6), pp.1069~1075 (2009)
- Ryu J, "Effects of the root of Platycodon grandiflorum on airway mucin hypersecretion in vivo and platycodin D(3)and deapi-platycodin on production and secretion of air way mucin in vitro", Phytomedicine, 21(4), pp.529~533 (2014)
- Gao Q, "Overview of the anti-inflammatory effects, pharmacokinetic properties and clinical efficacies of arctigenin and arctiin from Arctium lappa L", Acta Pharmacol Sin, 39(5), pp.787~801 (2018)
- Choi DH, "Comparative study of the biological activities effect of Mentha arvensis L. extracts from water and 80% ethanol", Journal of the Korean Applied Science and Technology, 36(1), pp.208~216 (2019)
- Kang HS, "Anti-inflammatory activity of arctigenin from Forsythiae Fructus", J Ethnopharmacol, 116(2), pp.305~312 (2008)