기침에 대한 반하사심탕의 효과 : 체계적인 문헌고찰과 메타분석
The Effect of Banhasasim-tang in Cough: A Systematic Review and Meta-analysis
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Objective: This study confirms the safety and efficacy of Banhasasim-tang (BST) against cough through systematic review and meta-analysis. Methods: PubMed, Cochrane, ScienceDirect, Wiley online library, OASIS, KISS, NDSL, RISS, Science and Technology Society Village, DBpia, CNKI, J-STAGE, and CiNii were used as search engines. The search period was from the start of search engine support to June 30. 2020. And search language was not limited. Cochrane’s risk of bias (RoB) tool was used to evaluate the quality of the studies. A meta-analysis of the total effective rate (TER), cough symptom score, and spirometry results was performed using the Review Manager program. Results: 6 studies were finally selected. The group using BST showed significant symptom relief, as the odds ratio (OR) value of TER was 5.56 times higher (95% CI: 3.50, 8.82, P<0.0001) compared to the control groups. The reported adverse effects did not occur in the intervention group. In addition, the cough symptom score and spirometry results showed that BST was more effective than Western medicine alone. Conclusion: BST can be expected to relieve cough, and it can be applied to chronic cough that is not treated with existing treatments. However, due to the low quality of the selected articles, additional high-quality RCTs will be required in the future.
Abstract
Objective: This study confirms the safety and efficacy of Banhasasim-tang (BST) against cough through systematic review and meta-analysis. Methods: PubMed, Cochrane, ScienceDirect, Wiley online library, OASIS, KISS, NDSL, RISS, Science and Technology Society Village, DBpia, CNKI, J-STAGE, and CiNii were used as search engines. The search period was from the start of search engine support to June 30. 2020. And search language was not limited. Cochrane’s risk of bias (RoB) tool was used to evaluate the quality of the studies. A meta-analysis of the total effective rate (TER), cough symptom score, and spirometry results was performed using the Review Manager program. Results: 6 studies were finally selected. The group using BST showed significant symptom relief, as the odds ratio (OR) value of TER was 5.56 times higher (95% CI: 3.50, 8.82, P<0.0001) compared to the control groups. The reported adverse effects did not occur in the intervention group. In addition, the cough symptom score and spirometry results showed that BST was more effective than Western medicine alone. Conclusion: BST can be expected to relieve cough, and it can be applied to chronic cough that is not treated with existing treatments. However, due to the low quality of the selected articles, additional high-quality RCTs will be required in the future.
참고문헌 (18)
- "National Health Insurance Statistical 2018"[URL]
- Ji YG, "Treatment of chronic cough", Korean journal of internal medicine, 64(2), pp.240~244 (2003)
- 송우정, "만성 기침의 새로운 임상 접근법: 최근 진료 지침을 기반으로", 대한내과학회지, 94(6), pp.471~484 (2019), 대한내과학회[DOI]
- The Korean Academy of Asthma, Allergy and Clinical Immunology, "A summary of the guidelines for chronic cough", The Korean Academy of Asthma, Allergy and Clinical Immunology, 4~ (2018)
- Heo J, "Dongui Bogam", pp.1338~ (2005), DonguiBogam Publishing Company
- Moon J, "Shanghanlun Jeonghae", pp.317~319 (2010), Haneui Munhwasa
- 전수연, "반하사심탕에 대한 임상연구 분석", 대한한의학 방제학회지, 26(3), pp.267~281 (2018), 대한한의학방제학회[DOI]
- 장명웅, "역류성 식도염 유발 생쥐의 半夏瀉心湯 투여 효과에 대한 실험 연구", 대한한방내과학회지, 34(4), pp.362~374 (2013), 대한한방내과학회
- Lu B, "Clinical Ｒesearch of Modified Banxia Xiexin Decoction in Treating Chronic Cough", China journal of chinese medicine, 28(8), pp.1118~1119 (2013)
- Lu B, "Effect and mechanism of Ban Xia Xie Xin Decoction combined with triple drug therapy of intractable chronic cough", Chinese Journal of Basic Medicine in Traditional Chinese Medicine, 20(8), pp.1087~1089 (2014)
- Wang BC, "Clinical Observation of Banxia Xiexin Decoction Combined with Proton Pump Inhibitor in Treating Gastroesophageal Reflux Cough", Chinese Journal of Modern Drug Application, 9(7), pp.156~158 (2015)
- Liu XL, "Evaluation of Effect of Banxia Xiexin Decoction on Chronic Cough", Renowned Doctor, 11, pp.237~ (2019)
- Kong Z, "Clinical Study of Banxia Xiexin Decoction in Treating Cough Variant Asthma", Chinese Journal of Basic Medicine in Traditional Chinese Medicine, 20(8), pp.1083~1084 (2014)
- Hwang YC, "Treatment of 42 Cases of Chronic Cough with Banxia Xiexin Decoction", Chinese medicine modern distance education of china, 12(20), pp.148~149 (2014)
- Korean Medical College Society Textbook Compilation Committee, "Herbal medicine", pp.485~486 (2011), Younglimsa
- 박근희, "半夏瀉心湯을 활용한 소화성 궤양 치험 3례", 동의생리병리학회지, 26(6), pp.940~946 (2012), 한의병리학회
- 안수빈, "항암화학요법으로 인한 증상에 대한 반하사심탕의 효과: 체계적 문헌고찰", 대한한방내과학회지, 40(4), pp.663~674 (2019), 대한한방내과학회[DOI]
- The Korean Academy of Tuberculosis and Respiratory Diseases, "Cough treatment guideline", The Korean Academy of Tuberculosis and Respiratory Diseases, 187~188 (2014)